Application Route and Immune Status of the Host Determine Safety and Oncolytic Activity of Oncolytic Coxsackievirus B3 Variant PD-H

The coxsackievirus B3 strain PD-0 has been proposed as a new oncolytic virus for the treatment of colorectal carcinoma. Here, we generated a cDNA clone of PD-0 and analyzed the virus PD-H, newly generated from this cDNA, in xenografted and syngenic models of colorectal cancer. Replication and cytoto...

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Detalles Bibliográficos
Autores principales: Hazini, Ahmet, Dieringer, Babette, Klingel, Karin, Pryshliak, Markian, Geisler, Anja, Kobelt, Dennis, Daberkow, Ole, Kurreck, Jens, van Linthout, Sophie, Fechner, Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539752/
https://www.ncbi.nlm.nih.gov/pubmed/34696348
http://dx.doi.org/10.3390/v13101918

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