The Timing and Effects of Low-Dose Ethanol Treatment on Acetaminophen-Induced Liver Injury

Acetaminophen (APAP) overdose is the major cause of drug-induced liver injury and acute liver failure. Approximately 10% of APAP is metabolized by cytochrome P450 (CYP2E1) into toxic N-acetyl-p-benzoquinone imine (NAPQI). CYP2E1 also contributes to ethanol metabolism, especially during conditions of...

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Detalles Bibliográficos
Autores principales: Liu, Fu-Chao, Yu, Huang-Ping, Liao, Chia-Chih, Chou, An-Hsun, Lee, Hung-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539755/
https://www.ncbi.nlm.nih.gov/pubmed/34685467
http://dx.doi.org/10.3390/life11101094

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