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Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study

Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such as gene electrotransfer, which can provide localized delivery of IL-12 to the tumor microenvironment. Gene elec...

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Detalles Bibliográficos
Autores principales:	Kos, Spela, Bosnjak, Masa, Jesenko, Tanja, Markelc, Bostjan, Kamensek, Urska, Znidar, Katarina, Matkovic, Urska, Rencelj, Andrej, Sersa, Gregor, Hudej, Rosana, Tuljak, Aneja, Peterka, Matjaz, Cemazar, Maja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539770/ https://www.ncbi.nlm.nih.gov/pubmed/34684032 http://dx.doi.org/10.3390/pharmaceutics13101739

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