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Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics
The advancement in therapy has provided a dramatic improvement in the rate of recovery among cancer patients. However, this improved survival is also associated with enhanced risks for cardiovascular manifestations, including hypertension, arrhythmias, and heart failure. The cardiotoxicity induced b...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539940/ https://www.ncbi.nlm.nih.gov/pubmed/34681194 http://dx.doi.org/10.3390/ph14100970 |
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| author | Adhikari, Archana Asdaq, Syed Mohammed Basheeruddin Al Hawaj, Maitham A. Chakraborty, Manodeep Thapa, Gayatri Bhuyan, Nihar Ranjan Imran, Mohd. Alshammari, Mohammed Kanan Alshehri, Mohammed M. Harshan, Aishah Ali Alanazi, Abeer Alhazmi, Bushra Dhuhayyan Sreeharsha, Nagaraja |
| author_facet | Adhikari, Archana Asdaq, Syed Mohammed Basheeruddin Al Hawaj, Maitham A. Chakraborty, Manodeep Thapa, Gayatri Bhuyan, Nihar Ranjan Imran, Mohd. Alshammari, Mohammed Kanan Alshehri, Mohammed M. Harshan, Aishah Ali Alanazi, Abeer Alhazmi, Bushra Dhuhayyan Sreeharsha, Nagaraja |
| author_sort | Adhikari, Archana |
| collection | PubMed |
| description | The advancement in therapy has provided a dramatic improvement in the rate of recovery among cancer patients. However, this improved survival is also associated with enhanced risks for cardiovascular manifestations, including hypertension, arrhythmias, and heart failure. The cardiotoxicity induced by chemotherapy is a life-threatening consequence that restricts the use of several chemotherapy drugs in clinical practice. This article addresses the prevalence of cardiotoxicity mediated by commonly used chemotherapeutic and immunotherapeutic agents. The role of susceptible genes and radiation therapy in the occurrence of cardiotoxicity is also reviewed. This review also emphasizes the protective role of antioxidants and future perspectives in anticancer drug-induced cardiotoxicities. |
| format | Online Article Text |
| id | pubmed-8539940 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85399402021-10-24 Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics Adhikari, Archana Asdaq, Syed Mohammed Basheeruddin Al Hawaj, Maitham A. Chakraborty, Manodeep Thapa, Gayatri Bhuyan, Nihar Ranjan Imran, Mohd. Alshammari, Mohammed Kanan Alshehri, Mohammed M. Harshan, Aishah Ali Alanazi, Abeer Alhazmi, Bushra Dhuhayyan Sreeharsha, Nagaraja Pharmaceuticals (Basel) Review The advancement in therapy has provided a dramatic improvement in the rate of recovery among cancer patients. However, this improved survival is also associated with enhanced risks for cardiovascular manifestations, including hypertension, arrhythmias, and heart failure. The cardiotoxicity induced by chemotherapy is a life-threatening consequence that restricts the use of several chemotherapy drugs in clinical practice. This article addresses the prevalence of cardiotoxicity mediated by commonly used chemotherapeutic and immunotherapeutic agents. The role of susceptible genes and radiation therapy in the occurrence of cardiotoxicity is also reviewed. This review also emphasizes the protective role of antioxidants and future perspectives in anticancer drug-induced cardiotoxicities. MDPI 2021-09-25 /pmc/articles/PMC8539940/ /pubmed/34681194 http://dx.doi.org/10.3390/ph14100970 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Adhikari, Archana Asdaq, Syed Mohammed Basheeruddin Al Hawaj, Maitham A. Chakraborty, Manodeep Thapa, Gayatri Bhuyan, Nihar Ranjan Imran, Mohd. Alshammari, Mohammed Kanan Alshehri, Mohammed M. Harshan, Aishah Ali Alanazi, Abeer Alhazmi, Bushra Dhuhayyan Sreeharsha, Nagaraja Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics |
| title | Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics |
| title_full | Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics |
| title_fullStr | Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics |
| title_full_unstemmed | Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics |
| title_short | Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics |
| title_sort | anticancer drug-induced cardiotoxicity: insights and pharmacogenetics |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539940/ https://www.ncbi.nlm.nih.gov/pubmed/34681194 http://dx.doi.org/10.3390/ph14100970 |
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