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A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps
Adenomatous polyps are precancerous lesions associated with a higher risk of colorectal cancer (CRC). Curcumin and anthocyanins have shown promising CRC-preventive activity in preclinical and epidemiological studies. The objective of this window-of-opportunity, proof-of principle trial was to evalua...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539981/ https://www.ncbi.nlm.nih.gov/pubmed/34681684 http://dx.doi.org/10.3390/ijms222011024 |
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author | Briata, Irene Maria Paleari, Laura Rutigliani, Mariangela Petrera, Marilena Caviglia, Silvia Romagnoli, Paola Libera, Mauro Dalla Oppezzi, Massimo Puntoni, Matteo Siri, Giacomo Lazzeroni, Matteo Howells, Lynne Singh, Raj Brown, Karen DeCensi, Andrea |
author_facet | Briata, Irene Maria Paleari, Laura Rutigliani, Mariangela Petrera, Marilena Caviglia, Silvia Romagnoli, Paola Libera, Mauro Dalla Oppezzi, Massimo Puntoni, Matteo Siri, Giacomo Lazzeroni, Matteo Howells, Lynne Singh, Raj Brown, Karen DeCensi, Andrea |
author_sort | Briata, Irene Maria |
collection | PubMed |
description | Adenomatous polyps are precancerous lesions associated with a higher risk of colorectal cancer (CRC). Curcumin and anthocyanins have shown promising CRC-preventive activity in preclinical and epidemiological studies. The objective of this window-of-opportunity, proof-of principle trial was to evaluate the effect of curcumin combined with anthocyanin supplements on tissue biomarkers of colorectal adenomatous polyps. Eligible patients received either anthocyanin and curcumin supplementation or related matching placebo for 4–6 weeks before polyp removal. Adenomatous polyps and adjacent tissue biopsies were collected at baseline and after supplementation for immunohistochemical assessment of β-catenin, NF-kappa B (NF-κB), Ki-67, P53, and dysplasia. No differences were observed in baseline biomarker expression between normal and dysplastic tissues. The combination of anthocyanins and curcumin resulted in a significant borderline reduction of NF-κB immunohistochemistry (IHC) expression in adenoma tissue (geometric mean ratio (GMR): 0.72; 95% confidence interval (CI): 0.51–1.00; p-value: 0.05) and a trend to a reduction of Ki-67 (GMR: 0.73; 95% CI: 0.50–1.08; p-value: 0.11). No significant modulation of biomarkers in normal adjacent mucosa was observed. We concluded that the combined supplementation of anthocyanins and curcumin seems to lead to a potentially favorable modulation of tissue biomarkers of inflammation and proliferation in colon adenomas. |
format | Online Article Text |
id | pubmed-8539981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85399812021-10-24 A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps Briata, Irene Maria Paleari, Laura Rutigliani, Mariangela Petrera, Marilena Caviglia, Silvia Romagnoli, Paola Libera, Mauro Dalla Oppezzi, Massimo Puntoni, Matteo Siri, Giacomo Lazzeroni, Matteo Howells, Lynne Singh, Raj Brown, Karen DeCensi, Andrea Int J Mol Sci Article Adenomatous polyps are precancerous lesions associated with a higher risk of colorectal cancer (CRC). Curcumin and anthocyanins have shown promising CRC-preventive activity in preclinical and epidemiological studies. The objective of this window-of-opportunity, proof-of principle trial was to evaluate the effect of curcumin combined with anthocyanin supplements on tissue biomarkers of colorectal adenomatous polyps. Eligible patients received either anthocyanin and curcumin supplementation or related matching placebo for 4–6 weeks before polyp removal. Adenomatous polyps and adjacent tissue biopsies were collected at baseline and after supplementation for immunohistochemical assessment of β-catenin, NF-kappa B (NF-κB), Ki-67, P53, and dysplasia. No differences were observed in baseline biomarker expression between normal and dysplastic tissues. The combination of anthocyanins and curcumin resulted in a significant borderline reduction of NF-κB immunohistochemistry (IHC) expression in adenoma tissue (geometric mean ratio (GMR): 0.72; 95% confidence interval (CI): 0.51–1.00; p-value: 0.05) and a trend to a reduction of Ki-67 (GMR: 0.73; 95% CI: 0.50–1.08; p-value: 0.11). No significant modulation of biomarkers in normal adjacent mucosa was observed. We concluded that the combined supplementation of anthocyanins and curcumin seems to lead to a potentially favorable modulation of tissue biomarkers of inflammation and proliferation in colon adenomas. MDPI 2021-10-13 /pmc/articles/PMC8539981/ /pubmed/34681684 http://dx.doi.org/10.3390/ijms222011024 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Briata, Irene Maria Paleari, Laura Rutigliani, Mariangela Petrera, Marilena Caviglia, Silvia Romagnoli, Paola Libera, Mauro Dalla Oppezzi, Massimo Puntoni, Matteo Siri, Giacomo Lazzeroni, Matteo Howells, Lynne Singh, Raj Brown, Karen DeCensi, Andrea A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps |
title | A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps |
title_full | A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps |
title_fullStr | A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps |
title_full_unstemmed | A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps |
title_short | A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps |
title_sort | presurgical study of curcumin combined with anthocyanin supplements in patients with colorectal adenomatous polyps |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539981/ https://www.ncbi.nlm.nih.gov/pubmed/34681684 http://dx.doi.org/10.3390/ijms222011024 |
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