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A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps

Adenomatous polyps are precancerous lesions associated with a higher risk of colorectal cancer (CRC). Curcumin and anthocyanins have shown promising CRC-preventive activity in preclinical and epidemiological studies. The objective of this window-of-opportunity, proof-of principle trial was to evalua...

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Autores principales: Briata, Irene Maria, Paleari, Laura, Rutigliani, Mariangela, Petrera, Marilena, Caviglia, Silvia, Romagnoli, Paola, Libera, Mauro Dalla, Oppezzi, Massimo, Puntoni, Matteo, Siri, Giacomo, Lazzeroni, Matteo, Howells, Lynne, Singh, Raj, Brown, Karen, DeCensi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539981/
https://www.ncbi.nlm.nih.gov/pubmed/34681684
http://dx.doi.org/10.3390/ijms222011024
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author Briata, Irene Maria
Paleari, Laura
Rutigliani, Mariangela
Petrera, Marilena
Caviglia, Silvia
Romagnoli, Paola
Libera, Mauro Dalla
Oppezzi, Massimo
Puntoni, Matteo
Siri, Giacomo
Lazzeroni, Matteo
Howells, Lynne
Singh, Raj
Brown, Karen
DeCensi, Andrea
author_facet Briata, Irene Maria
Paleari, Laura
Rutigliani, Mariangela
Petrera, Marilena
Caviglia, Silvia
Romagnoli, Paola
Libera, Mauro Dalla
Oppezzi, Massimo
Puntoni, Matteo
Siri, Giacomo
Lazzeroni, Matteo
Howells, Lynne
Singh, Raj
Brown, Karen
DeCensi, Andrea
author_sort Briata, Irene Maria
collection PubMed
description Adenomatous polyps are precancerous lesions associated with a higher risk of colorectal cancer (CRC). Curcumin and anthocyanins have shown promising CRC-preventive activity in preclinical and epidemiological studies. The objective of this window-of-opportunity, proof-of principle trial was to evaluate the effect of curcumin combined with anthocyanin supplements on tissue biomarkers of colorectal adenomatous polyps. Eligible patients received either anthocyanin and curcumin supplementation or related matching placebo for 4–6 weeks before polyp removal. Adenomatous polyps and adjacent tissue biopsies were collected at baseline and after supplementation for immunohistochemical assessment of β-catenin, NF-kappa B (NF-κB), Ki-67, P53, and dysplasia. No differences were observed in baseline biomarker expression between normal and dysplastic tissues. The combination of anthocyanins and curcumin resulted in a significant borderline reduction of NF-κB immunohistochemistry (IHC) expression in adenoma tissue (geometric mean ratio (GMR): 0.72; 95% confidence interval (CI): 0.51–1.00; p-value: 0.05) and a trend to a reduction of Ki-67 (GMR: 0.73; 95% CI: 0.50–1.08; p-value: 0.11). No significant modulation of biomarkers in normal adjacent mucosa was observed. We concluded that the combined supplementation of anthocyanins and curcumin seems to lead to a potentially favorable modulation of tissue biomarkers of inflammation and proliferation in colon adenomas.
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spelling pubmed-85399812021-10-24 A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps Briata, Irene Maria Paleari, Laura Rutigliani, Mariangela Petrera, Marilena Caviglia, Silvia Romagnoli, Paola Libera, Mauro Dalla Oppezzi, Massimo Puntoni, Matteo Siri, Giacomo Lazzeroni, Matteo Howells, Lynne Singh, Raj Brown, Karen DeCensi, Andrea Int J Mol Sci Article Adenomatous polyps are precancerous lesions associated with a higher risk of colorectal cancer (CRC). Curcumin and anthocyanins have shown promising CRC-preventive activity in preclinical and epidemiological studies. The objective of this window-of-opportunity, proof-of principle trial was to evaluate the effect of curcumin combined with anthocyanin supplements on tissue biomarkers of colorectal adenomatous polyps. Eligible patients received either anthocyanin and curcumin supplementation or related matching placebo for 4–6 weeks before polyp removal. Adenomatous polyps and adjacent tissue biopsies were collected at baseline and after supplementation for immunohistochemical assessment of β-catenin, NF-kappa B (NF-κB), Ki-67, P53, and dysplasia. No differences were observed in baseline biomarker expression between normal and dysplastic tissues. The combination of anthocyanins and curcumin resulted in a significant borderline reduction of NF-κB immunohistochemistry (IHC) expression in adenoma tissue (geometric mean ratio (GMR): 0.72; 95% confidence interval (CI): 0.51–1.00; p-value: 0.05) and a trend to a reduction of Ki-67 (GMR: 0.73; 95% CI: 0.50–1.08; p-value: 0.11). No significant modulation of biomarkers in normal adjacent mucosa was observed. We concluded that the combined supplementation of anthocyanins and curcumin seems to lead to a potentially favorable modulation of tissue biomarkers of inflammation and proliferation in colon adenomas. MDPI 2021-10-13 /pmc/articles/PMC8539981/ /pubmed/34681684 http://dx.doi.org/10.3390/ijms222011024 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Briata, Irene Maria
Paleari, Laura
Rutigliani, Mariangela
Petrera, Marilena
Caviglia, Silvia
Romagnoli, Paola
Libera, Mauro Dalla
Oppezzi, Massimo
Puntoni, Matteo
Siri, Giacomo
Lazzeroni, Matteo
Howells, Lynne
Singh, Raj
Brown, Karen
DeCensi, Andrea
A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps
title A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps
title_full A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps
title_fullStr A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps
title_full_unstemmed A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps
title_short A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps
title_sort presurgical study of curcumin combined with anthocyanin supplements in patients with colorectal adenomatous polyps
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539981/
https://www.ncbi.nlm.nih.gov/pubmed/34681684
http://dx.doi.org/10.3390/ijms222011024
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