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Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Ginsenosides are active compounds that are beneficial to bone metabolism and have anti-osteoporosis properties. However, very few clinical investigations have investigated the effect of ginseng extract (GE) on bone metabolism. This study aims to determine the effect of GE on improving bone metabolis...

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Autores principales: Jung, Su-Jin, Oh, Mi-Ra, Lee, Dae Young, Lee, Young-Seob, Kim, Geum-Soog, Park, Soo-Hyun, Han, Soog-Kyoung, Kim, Young-Ock, Yoon, Sun-Jung, Chae, Soo-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539988/
https://www.ncbi.nlm.nih.gov/pubmed/34684351
http://dx.doi.org/10.3390/nu13103352
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author Jung, Su-Jin
Oh, Mi-Ra
Lee, Dae Young
Lee, Young-Seob
Kim, Geum-Soog
Park, Soo-Hyun
Han, Soog-Kyoung
Kim, Young-Ock
Yoon, Sun-Jung
Chae, Soo-Wan
author_facet Jung, Su-Jin
Oh, Mi-Ra
Lee, Dae Young
Lee, Young-Seob
Kim, Geum-Soog
Park, Soo-Hyun
Han, Soog-Kyoung
Kim, Young-Ock
Yoon, Sun-Jung
Chae, Soo-Wan
author_sort Jung, Su-Jin
collection PubMed
description Ginsenosides are active compounds that are beneficial to bone metabolism and have anti-osteoporosis properties. However, very few clinical investigations have investigated the effect of ginseng extract (GE) on bone metabolism. This study aims to determine the effect of GE on improving bone metabolism and arthritis symptoms in postmenopausal women with osteopenia. A 12-week randomized, double-blind, placebo-controlled clinical trial was conducted. A total of 90 subjects were randomly divided into a placebo group, GE 1 g group, and GE 3 g group for 12 weeks based on the random 1:1:1 assignment to these three groups. The primary outcome is represented by bone metabolism indices consisting of serum osteocalcin (OC), urine deoxypyridinoline (DPD), and DPD/OC measurements. Secondary outcomes were serum CTX, NTX, Ca, P, BsALP, P1NP, OC/CTX ratio, and WOMAC index. The GE 3 g group had a significantly increased serum OC concentration. Similarly, the GE 3 g group showed a significant decrease in the DPD/OC ratio, representing bone resorption and bone formation. Moreover, among all the groups, the GE 3 g group demonstrated appreciable improvements in the WOMAC index scores. In women with osteopenia, intake of 3 g of GE per day over 12 weeks notably improved the knee arthritis symptoms with improvements in the OC concentration and ratios of bone formation indices like DPD/OC.
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spelling pubmed-85399882021-10-24 Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Jung, Su-Jin Oh, Mi-Ra Lee, Dae Young Lee, Young-Seob Kim, Geum-Soog Park, Soo-Hyun Han, Soog-Kyoung Kim, Young-Ock Yoon, Sun-Jung Chae, Soo-Wan Nutrients Article Ginsenosides are active compounds that are beneficial to bone metabolism and have anti-osteoporosis properties. However, very few clinical investigations have investigated the effect of ginseng extract (GE) on bone metabolism. This study aims to determine the effect of GE on improving bone metabolism and arthritis symptoms in postmenopausal women with osteopenia. A 12-week randomized, double-blind, placebo-controlled clinical trial was conducted. A total of 90 subjects were randomly divided into a placebo group, GE 1 g group, and GE 3 g group for 12 weeks based on the random 1:1:1 assignment to these three groups. The primary outcome is represented by bone metabolism indices consisting of serum osteocalcin (OC), urine deoxypyridinoline (DPD), and DPD/OC measurements. Secondary outcomes were serum CTX, NTX, Ca, P, BsALP, P1NP, OC/CTX ratio, and WOMAC index. The GE 3 g group had a significantly increased serum OC concentration. Similarly, the GE 3 g group showed a significant decrease in the DPD/OC ratio, representing bone resorption and bone formation. Moreover, among all the groups, the GE 3 g group demonstrated appreciable improvements in the WOMAC index scores. In women with osteopenia, intake of 3 g of GE per day over 12 weeks notably improved the knee arthritis symptoms with improvements in the OC concentration and ratios of bone formation indices like DPD/OC. MDPI 2021-09-24 /pmc/articles/PMC8539988/ /pubmed/34684351 http://dx.doi.org/10.3390/nu13103352 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jung, Su-Jin
Oh, Mi-Ra
Lee, Dae Young
Lee, Young-Seob
Kim, Geum-Soog
Park, Soo-Hyun
Han, Soog-Kyoung
Kim, Young-Ock
Yoon, Sun-Jung
Chae, Soo-Wan
Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_full Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_fullStr Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_full_unstemmed Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_short Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_sort effect of ginseng extracts on the improvement of osteopathic and arthritis symptoms in women with osteopenia: a randomized, double-blind, placebo-controlled clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539988/
https://www.ncbi.nlm.nih.gov/pubmed/34684351
http://dx.doi.org/10.3390/nu13103352
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