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Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform

The simple and functional modification of the nanoparticle’s surface is used to efficiently deliver chemotherapeutic drugs for anti-cancer treatment. Here, we construct a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes for the treatment of mouse breast cance...

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Detalles Bibliográficos
Autores principales: Ren, Lili, Qiu, Lirong, Huang, Binbin, Yin, Jun, Li, Yaning, Yang, Xiaolong, Chen, Guoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540031/
https://www.ncbi.nlm.nih.gov/pubmed/34684953
http://dx.doi.org/10.3390/nano11102513
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author Ren, Lili
Qiu, Lirong
Huang, Binbin
Yin, Jun
Li, Yaning
Yang, Xiaolong
Chen, Guoguang
author_facet Ren, Lili
Qiu, Lirong
Huang, Binbin
Yin, Jun
Li, Yaning
Yang, Xiaolong
Chen, Guoguang
author_sort Ren, Lili
collection PubMed
description The simple and functional modification of the nanoparticle’s surface is used to efficiently deliver chemotherapeutic drugs for anti-cancer treatment. Here, we construct a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes for the treatment of mouse breast cancer models. Compared with traditional free drug treatments, the biodegradable natural red blood cell membrane is combined with pure crystalline drugs. The nanoparticles obtained by the preparation method have superior properties, such as good stability, significantly delaying the release of drugs and enhancing the inhibitory effect on tumor cells. This study shows that the design of RBC as an outsourced drug delivery system provides a promising foundation for the continued development, clinical trials, and nanomedicine research of anti-cancer drug nanocarriers in the future.
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spelling pubmed-85400312021-10-24 Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform Ren, Lili Qiu, Lirong Huang, Binbin Yin, Jun Li, Yaning Yang, Xiaolong Chen, Guoguang Nanomaterials (Basel) Article The simple and functional modification of the nanoparticle’s surface is used to efficiently deliver chemotherapeutic drugs for anti-cancer treatment. Here, we construct a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes for the treatment of mouse breast cancer models. Compared with traditional free drug treatments, the biodegradable natural red blood cell membrane is combined with pure crystalline drugs. The nanoparticles obtained by the preparation method have superior properties, such as good stability, significantly delaying the release of drugs and enhancing the inhibitory effect on tumor cells. This study shows that the design of RBC as an outsourced drug delivery system provides a promising foundation for the continued development, clinical trials, and nanomedicine research of anti-cancer drug nanocarriers in the future. MDPI 2021-09-27 /pmc/articles/PMC8540031/ /pubmed/34684953 http://dx.doi.org/10.3390/nano11102513 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ren, Lili
Qiu, Lirong
Huang, Binbin
Yin, Jun
Li, Yaning
Yang, Xiaolong
Chen, Guoguang
Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform
title Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform
title_full Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform
title_fullStr Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform
title_full_unstemmed Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform
title_short Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform
title_sort preparation and characterization of anti-cancer crystal drugs based on erythrocyte membrane nanoplatform
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540031/
https://www.ncbi.nlm.nih.gov/pubmed/34684953
http://dx.doi.org/10.3390/nano11102513
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