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Defining Acute Coronary Syndrome through Metabolomics
As an emerging platform technology, metabolomics offers new insights into the pathomechanisms associated with complex disease conditions, including cardiovascular diseases. It also facilitates assessing the risk of developing the disease before its clinical manifestation. For this reason, metabolomi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540033/ https://www.ncbi.nlm.nih.gov/pubmed/34677400 http://dx.doi.org/10.3390/metabo11100685 |
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author | Surendran, Arun Atefi, Negar Zhang, Hannah Aliani, Michel Ravandi, Amir |
author_facet | Surendran, Arun Atefi, Negar Zhang, Hannah Aliani, Michel Ravandi, Amir |
author_sort | Surendran, Arun |
collection | PubMed |
description | As an emerging platform technology, metabolomics offers new insights into the pathomechanisms associated with complex disease conditions, including cardiovascular diseases. It also facilitates assessing the risk of developing the disease before its clinical manifestation. For this reason, metabolomics is of growing interest for understanding the pathogenesis of acute coronary syndromes (ACS), finding new biomarkers of ACS, and its associated risk management. Metabolomics-based studies in ACS have already demonstrated immense potential for biomarker discovery and mechanistic insights by identifying metabolomic signatures (e.g., branched-chain amino acids, acylcarnitines, lysophosphatidylcholines) associated with disease progression. Herein, we discuss the various metabolomics approaches and the challenges involved in metabolic profiling, focusing on ACS. Special attention has been paid to the clinical studies of metabolomics and lipidomics in ACS, with an emphasis on ischemia/reperfusion injury. |
format | Online Article Text |
id | pubmed-8540033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85400332021-10-24 Defining Acute Coronary Syndrome through Metabolomics Surendran, Arun Atefi, Negar Zhang, Hannah Aliani, Michel Ravandi, Amir Metabolites Review As an emerging platform technology, metabolomics offers new insights into the pathomechanisms associated with complex disease conditions, including cardiovascular diseases. It also facilitates assessing the risk of developing the disease before its clinical manifestation. For this reason, metabolomics is of growing interest for understanding the pathogenesis of acute coronary syndromes (ACS), finding new biomarkers of ACS, and its associated risk management. Metabolomics-based studies in ACS have already demonstrated immense potential for biomarker discovery and mechanistic insights by identifying metabolomic signatures (e.g., branched-chain amino acids, acylcarnitines, lysophosphatidylcholines) associated with disease progression. Herein, we discuss the various metabolomics approaches and the challenges involved in metabolic profiling, focusing on ACS. Special attention has been paid to the clinical studies of metabolomics and lipidomics in ACS, with an emphasis on ischemia/reperfusion injury. MDPI 2021-10-06 /pmc/articles/PMC8540033/ /pubmed/34677400 http://dx.doi.org/10.3390/metabo11100685 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Surendran, Arun Atefi, Negar Zhang, Hannah Aliani, Michel Ravandi, Amir Defining Acute Coronary Syndrome through Metabolomics |
title | Defining Acute Coronary Syndrome through Metabolomics |
title_full | Defining Acute Coronary Syndrome through Metabolomics |
title_fullStr | Defining Acute Coronary Syndrome through Metabolomics |
title_full_unstemmed | Defining Acute Coronary Syndrome through Metabolomics |
title_short | Defining Acute Coronary Syndrome through Metabolomics |
title_sort | defining acute coronary syndrome through metabolomics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540033/ https://www.ncbi.nlm.nih.gov/pubmed/34677400 http://dx.doi.org/10.3390/metabo11100685 |
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