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Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years

Background and objectives: The purpose of this study was to analyse the diagnostic and prognostic efficiency of the sentinel lymph node biopsy technique (SLNB). Materials and Methods: This is a prospective observational study performed by the Hospital Complex in Santiago de Compostela (CHUS) in Spai...

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Autores principales: Suárez-Ajuria, Maria, García-García, Abel, Suárez-Peñaranda, José M., Garrido-Pumar, Miguel, Chamorro-Petronacci, Cintia M., Somoza-Martín, José M., Pérez-Sayáns, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540189/
https://www.ncbi.nlm.nih.gov/pubmed/34684129
http://dx.doi.org/10.3390/medicina57101092
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author Suárez-Ajuria, Maria
García-García, Abel
Suárez-Peñaranda, José M.
Garrido-Pumar, Miguel
Chamorro-Petronacci, Cintia M.
Somoza-Martín, José M.
Pérez-Sayáns, Mario
author_facet Suárez-Ajuria, Maria
García-García, Abel
Suárez-Peñaranda, José M.
Garrido-Pumar, Miguel
Chamorro-Petronacci, Cintia M.
Somoza-Martín, José M.
Pérez-Sayáns, Mario
author_sort Suárez-Ajuria, Maria
collection PubMed
description Background and objectives: The purpose of this study was to analyse the diagnostic and prognostic efficiency of the sentinel lymph node biopsy technique (SLNB). Materials and Methods: This is a prospective observational study performed by the Hospital Complex in Santiago de Compostela (CHUS) in Spain, between February 2013 and June 2020. The study included 60 patients, who had been diagnosed with OSCC in stage T1/T2N0M0. Results: 10 patients (16.7%) presented with SN+ (sentinel node positive). The majority (80%) only presented subcapsular affection, however one case also presented with extracapsular affection. Using the Kaplan–Meier curves, we determined that the average survival estimation for SN− patients was 74.0 months (CI95% 67.6–80.5) and it was 45.4 months (CI95% 10.9–24.0) for SN+ patients (p = 0.002). SN+ patients presented an OR = 11.000 (CI95% 2.393–50.589, p = 0.002) for cancer-related mortality. In terms of the diagnostic performance of the SN (sentinel node) test, a 55% sensitivity, a 100% specificity, 100% PPV and a 84% NPV were obtained. The analysis using ROC (receiver operating characteristic) curves revealed an AUC = 0.671 (CI95% 0.492–0.850, p = 0.046). Conclusions: SLNB seems to be an adequate technique for the detection of hidden metastases.
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spelling pubmed-85401892021-10-24 Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years Suárez-Ajuria, Maria García-García, Abel Suárez-Peñaranda, José M. Garrido-Pumar, Miguel Chamorro-Petronacci, Cintia M. Somoza-Martín, José M. Pérez-Sayáns, Mario Medicina (Kaunas) Article Background and objectives: The purpose of this study was to analyse the diagnostic and prognostic efficiency of the sentinel lymph node biopsy technique (SLNB). Materials and Methods: This is a prospective observational study performed by the Hospital Complex in Santiago de Compostela (CHUS) in Spain, between February 2013 and June 2020. The study included 60 patients, who had been diagnosed with OSCC in stage T1/T2N0M0. Results: 10 patients (16.7%) presented with SN+ (sentinel node positive). The majority (80%) only presented subcapsular affection, however one case also presented with extracapsular affection. Using the Kaplan–Meier curves, we determined that the average survival estimation for SN− patients was 74.0 months (CI95% 67.6–80.5) and it was 45.4 months (CI95% 10.9–24.0) for SN+ patients (p = 0.002). SN+ patients presented an OR = 11.000 (CI95% 2.393–50.589, p = 0.002) for cancer-related mortality. In terms of the diagnostic performance of the SN (sentinel node) test, a 55% sensitivity, a 100% specificity, 100% PPV and a 84% NPV were obtained. The analysis using ROC (receiver operating characteristic) curves revealed an AUC = 0.671 (CI95% 0.492–0.850, p = 0.046). Conclusions: SLNB seems to be an adequate technique for the detection of hidden metastases. MDPI 2021-10-12 /pmc/articles/PMC8540189/ /pubmed/34684129 http://dx.doi.org/10.3390/medicina57101092 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suárez-Ajuria, Maria
García-García, Abel
Suárez-Peñaranda, José M.
Garrido-Pumar, Miguel
Chamorro-Petronacci, Cintia M.
Somoza-Martín, José M.
Pérez-Sayáns, Mario
Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years
title Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years
title_full Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years
title_fullStr Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years
title_full_unstemmed Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years
title_short Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years
title_sort analysis of the efficiency and prognostic value of the sentinel node technique in oral squamous cell carcinoma after seven years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540189/
https://www.ncbi.nlm.nih.gov/pubmed/34684129
http://dx.doi.org/10.3390/medicina57101092
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