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Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Zeolites and zeolitic imidazolate frameworks (ZIFs) are widely studied as drug carrying nanoplatforms to enhance the specificity and efficacy of traditional anticancer drugs. At present, there is no other systematic review that assesses the potency of zeolites/ZIFs as anticancer drug carriers. Due t...

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Autores principales: Hao, Jessica, Stavljenić Milašin, Ivana, Batu Eken, Zeynep, Mravak-Stipetic, Marinka, Pavelić, Krešimir, Ozer, Fusun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540241/
https://www.ncbi.nlm.nih.gov/pubmed/34684777
http://dx.doi.org/10.3390/molecules26206196
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author Hao, Jessica
Stavljenić Milašin, Ivana
Batu Eken, Zeynep
Mravak-Stipetic, Marinka
Pavelić, Krešimir
Ozer, Fusun
author_facet Hao, Jessica
Stavljenić Milašin, Ivana
Batu Eken, Zeynep
Mravak-Stipetic, Marinka
Pavelić, Krešimir
Ozer, Fusun
author_sort Hao, Jessica
collection PubMed
description Zeolites and zeolitic imidazolate frameworks (ZIFs) are widely studied as drug carrying nanoplatforms to enhance the specificity and efficacy of traditional anticancer drugs. At present, there is no other systematic review that assesses the potency of zeolites/ZIFs as anticancer drug carriers. Due to the porous nature and inherent pH-sensitive properties of zeolites/ZIFs, the compounds can entrap and selectively release anticancer drugs into the acidic tumor microenvironment. Therefore, it is valuable to provide a comprehensive overview of available evidence on the topic to identify the benefits of the compound as well as potential gaps in knowledge. The purpose of this study was to evaluate the potential therapeutic applications of zeolites/ZIFs as drug delivery systems delivering doxorubicin (DOX), 5-fluorouracil (5-FU), curcumin, cisplatin, and miR-34a. Following PRISMA guidelines, an exhaustive search of PubMed, Scopus, Embase, and Web of Science was conducted. No language or time limitations were used up to 25th August 2021. Only full text articles were selected that pertained to the usage of zeolites/ZIFs in delivering anticancer drugs. Initially, 1279 studies were identified, of which 572 duplicate records were excluded. After screening for the title, abstract, and full texts, 53 articles remained and were included in the qualitative synthesis. An Inter-Rater Reliability (IRR) test, which included a percent user agreement and reliability percent, was conducted for the 53 articles. The included studies suggest that anticancer drug-incorporated zeolites/ZIFs can be used as alternative treatment options to enhance the efficacy of cancer treatment by mitigating the drawbacks of drugs under conventional treatment.
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spelling pubmed-85402412021-10-24 Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review Hao, Jessica Stavljenić Milašin, Ivana Batu Eken, Zeynep Mravak-Stipetic, Marinka Pavelić, Krešimir Ozer, Fusun Molecules Review Zeolites and zeolitic imidazolate frameworks (ZIFs) are widely studied as drug carrying nanoplatforms to enhance the specificity and efficacy of traditional anticancer drugs. At present, there is no other systematic review that assesses the potency of zeolites/ZIFs as anticancer drug carriers. Due to the porous nature and inherent pH-sensitive properties of zeolites/ZIFs, the compounds can entrap and selectively release anticancer drugs into the acidic tumor microenvironment. Therefore, it is valuable to provide a comprehensive overview of available evidence on the topic to identify the benefits of the compound as well as potential gaps in knowledge. The purpose of this study was to evaluate the potential therapeutic applications of zeolites/ZIFs as drug delivery systems delivering doxorubicin (DOX), 5-fluorouracil (5-FU), curcumin, cisplatin, and miR-34a. Following PRISMA guidelines, an exhaustive search of PubMed, Scopus, Embase, and Web of Science was conducted. No language or time limitations were used up to 25th August 2021. Only full text articles were selected that pertained to the usage of zeolites/ZIFs in delivering anticancer drugs. Initially, 1279 studies were identified, of which 572 duplicate records were excluded. After screening for the title, abstract, and full texts, 53 articles remained and were included in the qualitative synthesis. An Inter-Rater Reliability (IRR) test, which included a percent user agreement and reliability percent, was conducted for the 53 articles. The included studies suggest that anticancer drug-incorporated zeolites/ZIFs can be used as alternative treatment options to enhance the efficacy of cancer treatment by mitigating the drawbacks of drugs under conventional treatment. MDPI 2021-10-14 /pmc/articles/PMC8540241/ /pubmed/34684777 http://dx.doi.org/10.3390/molecules26206196 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hao, Jessica
Stavljenić Milašin, Ivana
Batu Eken, Zeynep
Mravak-Stipetic, Marinka
Pavelić, Krešimir
Ozer, Fusun
Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review
title Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review
title_full Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review
title_fullStr Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review
title_full_unstemmed Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review
title_short Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review
title_sort effects of zeolite as a drug delivery system on cancer therapy: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540241/
https://www.ncbi.nlm.nih.gov/pubmed/34684777
http://dx.doi.org/10.3390/molecules26206196
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