Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening

A major bottleneck in the successful development of central nervous system (CNS) drugs is the discovery and design of molecules that can cross the blood-brain barrier (BBB). Nano-delivery strategies are a promising approach that take advantage of natural portals of entry into the brain such as monoc...

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Detalles Bibliográficos
Autores principales: Aguiar, Sandra Isabel, Dias, Joana N. R., André, Ana Santos, Silva, Marta Lisete, Martins, Diana, Carrapiço, Belmira, Castanho, Miguel, Carriço, João, Cavaco, Marco, Gaspar, Maria Manuela, Nobre, Rui Jorge, Pereira de Almeida, Luís, Oliveira, Soraia, Gano, Lurdes, Correia, João D. G., Barbas, Carlos, Gonçalves, João, Neves, Vera, Aires-da-Silva, Frederico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540410/
https://www.ncbi.nlm.nih.gov/pubmed/34683891
http://dx.doi.org/10.3390/pharmaceutics13101598

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