Studies towards the Design and Synthesis of Novel 1,5-Diaryl-1H-imidazole-4-carboxylic Acids and 1,5-Diaryl-1H-imidazole-4-carbohydrazides as Host LEDGF/p75 and HIV-1 Integrase Interaction Inhibitors

Two targeted sets of novel 1,5-diaryl-1H-imidazole-4-carboxylic acids 10 and carbohydrazides 11 were designed and synthesized from their corresponding ester intermediates 17, which were prepared via cycloaddition of ethyl isocyanoacetate 16 and diarylimidoyl chlorides 15. Evaluation of these new tar...

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Detalles Bibliográficos
Autores principales: Rashamuse, Thompho J., Fish, Muhammad Q., Coyanis, E. Mabel, Bode, Moira L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540437/
https://www.ncbi.nlm.nih.gov/pubmed/34684786
http://dx.doi.org/10.3390/molecules26206203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540437/
https://www.ncbi.nlm.nih.gov/pubmed/34684786
http://dx.doi.org/10.3390/molecules26206203

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