Cargando…

Development and Validation of a Questionnaire to Measure Medication Adherence to Direct-Acting Agents in Patients with Hepatitis C

This study aims to develop a new self-report tool (HCV-AD) measuring adherence factors, intentional or unintentional, during Hepatitis C Virus (HCV) treatment with direct-acting antivirals (DAA) aiming to achieve high efficacy, otherwise resulting in drug resistance and treatment failure. Two phases...

Descripción completa

Detalles Bibliográficos
Autores principales: Turcu-Stiolica, Adina, Doica, Irina Paula, Ungureanu, Bogdan Silviu, Rogoveanu, Ion, Florescu, Dan Nicolae, Subtirelu, Mihaela-Simona, Gheonea, Dan Ionut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540644/
https://www.ncbi.nlm.nih.gov/pubmed/34683976
http://dx.doi.org/10.3390/pharmaceutics13101683
_version_ 1784589037027196928
author Turcu-Stiolica, Adina
Doica, Irina Paula
Ungureanu, Bogdan Silviu
Rogoveanu, Ion
Florescu, Dan Nicolae
Subtirelu, Mihaela-Simona
Gheonea, Dan Ionut
author_facet Turcu-Stiolica, Adina
Doica, Irina Paula
Ungureanu, Bogdan Silviu
Rogoveanu, Ion
Florescu, Dan Nicolae
Subtirelu, Mihaela-Simona
Gheonea, Dan Ionut
author_sort Turcu-Stiolica, Adina
collection PubMed
description This study aims to develop a new self-report tool (HCV-AD) measuring adherence factors, intentional or unintentional, during Hepatitis C Virus (HCV) treatment with direct-acting antivirals (DAA) aiming to achieve high efficacy, otherwise resulting in drug resistance and treatment failure. Two phases were conducted: in the first phase, items were generated based on an extensive literature review, and, in the second phase, a prospective cohort study was conducted using HCV patients from Gastroenterology Department from University County Hospital of Craiova, Romania (n = 222), to evaluate the validity and reliability of the questionnaire. A number of 19 items were generated following a systematic review and through expert opinion. The internal consistency reliability was evaluated using Cronbach’s alpha. The construct validity was assessed using correlations with two other instruments: visual analog scale (VAS) and medication possession ratio (MPR). The final questionnaire (HCV-AD10) was derived through exploratory factor analysis, with 82% of total variance explained. This instrument appeared as a reliable and valid measure for medication adherence, with Cronbach’s alpha (0.867) and significant high positive correlations between adherence scores calculated with HCV-AD10 and VAS (ρ = 0.61, p < 0.001) or with HCV-AD10 and MPR (ρ = 0.75, p < 0.001). This research would make a worthwhile contribution to HCV management.
format Online
Article
Text
id pubmed-8540644
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85406442021-10-24 Development and Validation of a Questionnaire to Measure Medication Adherence to Direct-Acting Agents in Patients with Hepatitis C Turcu-Stiolica, Adina Doica, Irina Paula Ungureanu, Bogdan Silviu Rogoveanu, Ion Florescu, Dan Nicolae Subtirelu, Mihaela-Simona Gheonea, Dan Ionut Pharmaceutics Article This study aims to develop a new self-report tool (HCV-AD) measuring adherence factors, intentional or unintentional, during Hepatitis C Virus (HCV) treatment with direct-acting antivirals (DAA) aiming to achieve high efficacy, otherwise resulting in drug resistance and treatment failure. Two phases were conducted: in the first phase, items were generated based on an extensive literature review, and, in the second phase, a prospective cohort study was conducted using HCV patients from Gastroenterology Department from University County Hospital of Craiova, Romania (n = 222), to evaluate the validity and reliability of the questionnaire. A number of 19 items were generated following a systematic review and through expert opinion. The internal consistency reliability was evaluated using Cronbach’s alpha. The construct validity was assessed using correlations with two other instruments: visual analog scale (VAS) and medication possession ratio (MPR). The final questionnaire (HCV-AD10) was derived through exploratory factor analysis, with 82% of total variance explained. This instrument appeared as a reliable and valid measure for medication adherence, with Cronbach’s alpha (0.867) and significant high positive correlations between adherence scores calculated with HCV-AD10 and VAS (ρ = 0.61, p < 0.001) or with HCV-AD10 and MPR (ρ = 0.75, p < 0.001). This research would make a worthwhile contribution to HCV management. MDPI 2021-10-14 /pmc/articles/PMC8540644/ /pubmed/34683976 http://dx.doi.org/10.3390/pharmaceutics13101683 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Turcu-Stiolica, Adina
Doica, Irina Paula
Ungureanu, Bogdan Silviu
Rogoveanu, Ion
Florescu, Dan Nicolae
Subtirelu, Mihaela-Simona
Gheonea, Dan Ionut
Development and Validation of a Questionnaire to Measure Medication Adherence to Direct-Acting Agents in Patients with Hepatitis C
title Development and Validation of a Questionnaire to Measure Medication Adherence to Direct-Acting Agents in Patients with Hepatitis C
title_full Development and Validation of a Questionnaire to Measure Medication Adherence to Direct-Acting Agents in Patients with Hepatitis C
title_fullStr Development and Validation of a Questionnaire to Measure Medication Adherence to Direct-Acting Agents in Patients with Hepatitis C
title_full_unstemmed Development and Validation of a Questionnaire to Measure Medication Adherence to Direct-Acting Agents in Patients with Hepatitis C
title_short Development and Validation of a Questionnaire to Measure Medication Adherence to Direct-Acting Agents in Patients with Hepatitis C
title_sort development and validation of a questionnaire to measure medication adherence to direct-acting agents in patients with hepatitis c
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540644/
https://www.ncbi.nlm.nih.gov/pubmed/34683976
http://dx.doi.org/10.3390/pharmaceutics13101683
work_keys_str_mv AT turcustiolicaadina developmentandvalidationofaquestionnairetomeasuremedicationadherencetodirectactingagentsinpatientswithhepatitisc
AT doicairinapaula developmentandvalidationofaquestionnairetomeasuremedicationadherencetodirectactingagentsinpatientswithhepatitisc
AT ungureanubogdansilviu developmentandvalidationofaquestionnairetomeasuremedicationadherencetodirectactingagentsinpatientswithhepatitisc
AT rogoveanuion developmentandvalidationofaquestionnairetomeasuremedicationadherencetodirectactingagentsinpatientswithhepatitisc
AT florescudannicolae developmentandvalidationofaquestionnairetomeasuremedicationadherencetodirectactingagentsinpatientswithhepatitisc
AT subtirelumihaelasimona developmentandvalidationofaquestionnairetomeasuremedicationadherencetodirectactingagentsinpatientswithhepatitisc
AT gheoneadanionut developmentandvalidationofaquestionnairetomeasuremedicationadherencetodirectactingagentsinpatientswithhepatitisc