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Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy
The use of short oligonucleotide or peptide molecules as target-specific aptamers has recently garnered substantial attention in the field of the detection and treatment of viral infections. Based on their high affinity and high specificity to desired targets, their use is on the rise to replace ant...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540715/ https://www.ncbi.nlm.nih.gov/pubmed/34683938 http://dx.doi.org/10.3390/pharmaceutics13101646 |
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author | Yadavalli, Tejabhiram Volety, Ipsita Shukla, Deepak |
author_facet | Yadavalli, Tejabhiram Volety, Ipsita Shukla, Deepak |
author_sort | Yadavalli, Tejabhiram |
collection | PubMed |
description | The use of short oligonucleotide or peptide molecules as target-specific aptamers has recently garnered substantial attention in the field of the detection and treatment of viral infections. Based on their high affinity and high specificity to desired targets, their use is on the rise to replace antibodies for the detection of viruses and viral antigens. Furthermore, aptamers inhibit intracellular viral transcription and translation, in addition to restricting viral entry into host cells. This has opened up a plethora of new targets for the research and development of novel vaccines against viruses. Here, we discuss the advances made in aptamer technology for viral diagnosis and therapy in the past decade. |
format | Online Article Text |
id | pubmed-8540715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85407152021-10-24 Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy Yadavalli, Tejabhiram Volety, Ipsita Shukla, Deepak Pharmaceutics Review The use of short oligonucleotide or peptide molecules as target-specific aptamers has recently garnered substantial attention in the field of the detection and treatment of viral infections. Based on their high affinity and high specificity to desired targets, their use is on the rise to replace antibodies for the detection of viruses and viral antigens. Furthermore, aptamers inhibit intracellular viral transcription and translation, in addition to restricting viral entry into host cells. This has opened up a plethora of new targets for the research and development of novel vaccines against viruses. Here, we discuss the advances made in aptamer technology for viral diagnosis and therapy in the past decade. MDPI 2021-10-09 /pmc/articles/PMC8540715/ /pubmed/34683938 http://dx.doi.org/10.3390/pharmaceutics13101646 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yadavalli, Tejabhiram Volety, Ipsita Shukla, Deepak Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy |
title | Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy |
title_full | Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy |
title_fullStr | Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy |
title_full_unstemmed | Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy |
title_short | Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy |
title_sort | aptamers in virology—a consolidated review of the most recent advancements in diagnosis and therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540715/ https://www.ncbi.nlm.nih.gov/pubmed/34683938 http://dx.doi.org/10.3390/pharmaceutics13101646 |
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