Cargando…
Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project
Background: The efficacy of SARS-CoV-2 vaccination among kidney transplant recipients (KTR) is low. The main goal of this study was to analyze factors that may influence the humoral response to vaccination. Methods: We analyzed the titer magnitude of IgG antibodies directed against spike (S)-SARS-Co...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540727/ https://www.ncbi.nlm.nih.gov/pubmed/34696273 http://dx.doi.org/10.3390/vaccines9101165 |
_version_ | 1784589057036124160 |
---|---|
author | Dębska-Ślizień, Alicja Ślizień, Zuzanna Muchlado, Marta Kubanek, Alicja Piotrowska, Magdalena Dąbrowska, Małgorzata Tarasewicz, Agnieszka Chamienia, Andrzej Biedunkiewicz, Bogdan Renke, Marcin Tylicki, Leszek |
author_facet | Dębska-Ślizień, Alicja Ślizień, Zuzanna Muchlado, Marta Kubanek, Alicja Piotrowska, Magdalena Dąbrowska, Małgorzata Tarasewicz, Agnieszka Chamienia, Andrzej Biedunkiewicz, Bogdan Renke, Marcin Tylicki, Leszek |
author_sort | Dębska-Ślizień, Alicja |
collection | PubMed |
description | Background: The efficacy of SARS-CoV-2 vaccination among kidney transplant recipients (KTR) is low. The main goal of this study was to analyze factors that may influence the humoral response to vaccination. Methods: We analyzed the titer magnitude of IgG antibodies directed against spike (S)-SARS-CoV-2 antigen after the second dose of the mRNA vaccine in 142 infection naïve KTR (83 men, i.e., 58.4%) with a median age (IQR) of 54 (41–63), and 36 respective controls without chronic kidney disease. mRNA-1273 or BNT162b2 were applied in 26% and 74% of KTR, respectively. Results: S-specific immune response (seroconversion) was seen in 73 (51.41%) of KTR, and in all controls 36 (100%). Independent predictors of no response were elder age, shorter transplantation vintage, and a more than two-drug immunosuppressive protocol. In subgroup analyses, the seroconversion rate was highest among KTR without MMF/MPS treatment (70%), treated with no more than two immunosuppressants (69.2%), treated without corticosteroid (66.7%), younger patients aged <54 years (63.2%), and those vaccinated with the mRNA-1273 vaccine (62.16%). The independent predictors of higher S-antibody titer among responders were younger age, treatment with no more than two immunosuppressants, and the mRNA-1273 vaccination. Conclusions: Our study confirmed a low rate of seroconversion after vaccination with the mRNA vaccine in KTR. The major modifiable determinants of humoral response were the composition of the immunosuppressive protocol, as well as the type of vaccine. The latter could be taken into consideration when initial vaccination as well as booster vaccination is considered in KTR. |
format | Online Article Text |
id | pubmed-8540727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85407272021-10-24 Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project Dębska-Ślizień, Alicja Ślizień, Zuzanna Muchlado, Marta Kubanek, Alicja Piotrowska, Magdalena Dąbrowska, Małgorzata Tarasewicz, Agnieszka Chamienia, Andrzej Biedunkiewicz, Bogdan Renke, Marcin Tylicki, Leszek Vaccines (Basel) Article Background: The efficacy of SARS-CoV-2 vaccination among kidney transplant recipients (KTR) is low. The main goal of this study was to analyze factors that may influence the humoral response to vaccination. Methods: We analyzed the titer magnitude of IgG antibodies directed against spike (S)-SARS-CoV-2 antigen after the second dose of the mRNA vaccine in 142 infection naïve KTR (83 men, i.e., 58.4%) with a median age (IQR) of 54 (41–63), and 36 respective controls without chronic kidney disease. mRNA-1273 or BNT162b2 were applied in 26% and 74% of KTR, respectively. Results: S-specific immune response (seroconversion) was seen in 73 (51.41%) of KTR, and in all controls 36 (100%). Independent predictors of no response were elder age, shorter transplantation vintage, and a more than two-drug immunosuppressive protocol. In subgroup analyses, the seroconversion rate was highest among KTR without MMF/MPS treatment (70%), treated with no more than two immunosuppressants (69.2%), treated without corticosteroid (66.7%), younger patients aged <54 years (63.2%), and those vaccinated with the mRNA-1273 vaccine (62.16%). The independent predictors of higher S-antibody titer among responders were younger age, treatment with no more than two immunosuppressants, and the mRNA-1273 vaccination. Conclusions: Our study confirmed a low rate of seroconversion after vaccination with the mRNA vaccine in KTR. The major modifiable determinants of humoral response were the composition of the immunosuppressive protocol, as well as the type of vaccine. The latter could be taken into consideration when initial vaccination as well as booster vaccination is considered in KTR. MDPI 2021-10-12 /pmc/articles/PMC8540727/ /pubmed/34696273 http://dx.doi.org/10.3390/vaccines9101165 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dębska-Ślizień, Alicja Ślizień, Zuzanna Muchlado, Marta Kubanek, Alicja Piotrowska, Magdalena Dąbrowska, Małgorzata Tarasewicz, Agnieszka Chamienia, Andrzej Biedunkiewicz, Bogdan Renke, Marcin Tylicki, Leszek Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project |
title | Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project |
title_full | Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project |
title_fullStr | Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project |
title_full_unstemmed | Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project |
title_short | Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project |
title_sort | predictors of humoral response to mrna covid19 vaccines in kidney transplant recipients: a longitudinal study—the covineph project |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540727/ https://www.ncbi.nlm.nih.gov/pubmed/34696273 http://dx.doi.org/10.3390/vaccines9101165 |
work_keys_str_mv | AT debskaslizienalicja predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT slizienzuzanna predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT muchladomarta predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT kubanekalicja predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT piotrowskamagdalena predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT dabrowskamałgorzata predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT tarasewiczagnieszka predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT chamieniaandrzej predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT biedunkiewiczbogdan predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT renkemarcin predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject AT tylickileszek predictorsofhumoralresponsetomrnacovid19vaccinesinkidneytransplantrecipientsalongitudinalstudythecovinephproject |