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Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project

Background: The efficacy of SARS-CoV-2 vaccination among kidney transplant recipients (KTR) is low. The main goal of this study was to analyze factors that may influence the humoral response to vaccination. Methods: We analyzed the titer magnitude of IgG antibodies directed against spike (S)-SARS-Co...

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Autores principales: Dębska-Ślizień, Alicja, Ślizień, Zuzanna, Muchlado, Marta, Kubanek, Alicja, Piotrowska, Magdalena, Dąbrowska, Małgorzata, Tarasewicz, Agnieszka, Chamienia, Andrzej, Biedunkiewicz, Bogdan, Renke, Marcin, Tylicki, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540727/
https://www.ncbi.nlm.nih.gov/pubmed/34696273
http://dx.doi.org/10.3390/vaccines9101165
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author Dębska-Ślizień, Alicja
Ślizień, Zuzanna
Muchlado, Marta
Kubanek, Alicja
Piotrowska, Magdalena
Dąbrowska, Małgorzata
Tarasewicz, Agnieszka
Chamienia, Andrzej
Biedunkiewicz, Bogdan
Renke, Marcin
Tylicki, Leszek
author_facet Dębska-Ślizień, Alicja
Ślizień, Zuzanna
Muchlado, Marta
Kubanek, Alicja
Piotrowska, Magdalena
Dąbrowska, Małgorzata
Tarasewicz, Agnieszka
Chamienia, Andrzej
Biedunkiewicz, Bogdan
Renke, Marcin
Tylicki, Leszek
author_sort Dębska-Ślizień, Alicja
collection PubMed
description Background: The efficacy of SARS-CoV-2 vaccination among kidney transplant recipients (KTR) is low. The main goal of this study was to analyze factors that may influence the humoral response to vaccination. Methods: We analyzed the titer magnitude of IgG antibodies directed against spike (S)-SARS-CoV-2 antigen after the second dose of the mRNA vaccine in 142 infection naïve KTR (83 men, i.e., 58.4%) with a median age (IQR) of 54 (41–63), and 36 respective controls without chronic kidney disease. mRNA-1273 or BNT162b2 were applied in 26% and 74% of KTR, respectively. Results: S-specific immune response (seroconversion) was seen in 73 (51.41%) of KTR, and in all controls 36 (100%). Independent predictors of no response were elder age, shorter transplantation vintage, and a more than two-drug immunosuppressive protocol. In subgroup analyses, the seroconversion rate was highest among KTR without MMF/MPS treatment (70%), treated with no more than two immunosuppressants (69.2%), treated without corticosteroid (66.7%), younger patients aged <54 years (63.2%), and those vaccinated with the mRNA-1273 vaccine (62.16%). The independent predictors of higher S-antibody titer among responders were younger age, treatment with no more than two immunosuppressants, and the mRNA-1273 vaccination. Conclusions: Our study confirmed a low rate of seroconversion after vaccination with the mRNA vaccine in KTR. The major modifiable determinants of humoral response were the composition of the immunosuppressive protocol, as well as the type of vaccine. The latter could be taken into consideration when initial vaccination as well as booster vaccination is considered in KTR.
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spelling pubmed-85407272021-10-24 Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project Dębska-Ślizień, Alicja Ślizień, Zuzanna Muchlado, Marta Kubanek, Alicja Piotrowska, Magdalena Dąbrowska, Małgorzata Tarasewicz, Agnieszka Chamienia, Andrzej Biedunkiewicz, Bogdan Renke, Marcin Tylicki, Leszek Vaccines (Basel) Article Background: The efficacy of SARS-CoV-2 vaccination among kidney transplant recipients (KTR) is low. The main goal of this study was to analyze factors that may influence the humoral response to vaccination. Methods: We analyzed the titer magnitude of IgG antibodies directed against spike (S)-SARS-CoV-2 antigen after the second dose of the mRNA vaccine in 142 infection naïve KTR (83 men, i.e., 58.4%) with a median age (IQR) of 54 (41–63), and 36 respective controls without chronic kidney disease. mRNA-1273 or BNT162b2 were applied in 26% and 74% of KTR, respectively. Results: S-specific immune response (seroconversion) was seen in 73 (51.41%) of KTR, and in all controls 36 (100%). Independent predictors of no response were elder age, shorter transplantation vintage, and a more than two-drug immunosuppressive protocol. In subgroup analyses, the seroconversion rate was highest among KTR without MMF/MPS treatment (70%), treated with no more than two immunosuppressants (69.2%), treated without corticosteroid (66.7%), younger patients aged <54 years (63.2%), and those vaccinated with the mRNA-1273 vaccine (62.16%). The independent predictors of higher S-antibody titer among responders were younger age, treatment with no more than two immunosuppressants, and the mRNA-1273 vaccination. Conclusions: Our study confirmed a low rate of seroconversion after vaccination with the mRNA vaccine in KTR. The major modifiable determinants of humoral response were the composition of the immunosuppressive protocol, as well as the type of vaccine. The latter could be taken into consideration when initial vaccination as well as booster vaccination is considered in KTR. MDPI 2021-10-12 /pmc/articles/PMC8540727/ /pubmed/34696273 http://dx.doi.org/10.3390/vaccines9101165 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dębska-Ślizień, Alicja
Ślizień, Zuzanna
Muchlado, Marta
Kubanek, Alicja
Piotrowska, Magdalena
Dąbrowska, Małgorzata
Tarasewicz, Agnieszka
Chamienia, Andrzej
Biedunkiewicz, Bogdan
Renke, Marcin
Tylicki, Leszek
Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project
title Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project
title_full Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project
title_fullStr Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project
title_full_unstemmed Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project
title_short Predictors of Humoral Response to mRNA COVID19 Vaccines in Kidney Transplant Recipients: A Longitudinal Study—The COViNEPH Project
title_sort predictors of humoral response to mrna covid19 vaccines in kidney transplant recipients: a longitudinal study—the covineph project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540727/
https://www.ncbi.nlm.nih.gov/pubmed/34696273
http://dx.doi.org/10.3390/vaccines9101165
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