Cargando…
Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation
Laser-generated focused ultrasound (LGFU) is an emerging modality for cavitation-based therapy. However, focal pressure amplitudes by LGFU alone to achieve pulsed cavitation are often lacking as a treatment depth increases. This requires a higher pressure from a transmitter surface and more laser en...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540735/ https://www.ncbi.nlm.nih.gov/pubmed/34683319 http://dx.doi.org/10.3390/mi12101268 |
_version_ | 1784589058909929472 |
---|---|
author | Sang, Pil Gyu Biswas, Deblina Lee, Seung Jin Won, Sang Min Son, Donghee Ok, Jong G. Park, Hui Joon Baac, Hyoung Won |
author_facet | Sang, Pil Gyu Biswas, Deblina Lee, Seung Jin Won, Sang Min Son, Donghee Ok, Jong G. Park, Hui Joon Baac, Hyoung Won |
author_sort | Sang, Pil Gyu |
collection | PubMed |
description | Laser-generated focused ultrasound (LGFU) is an emerging modality for cavitation-based therapy. However, focal pressure amplitudes by LGFU alone to achieve pulsed cavitation are often lacking as a treatment depth increases. This requires a higher pressure from a transmitter surface and more laser energies that even approach to a damage threshold of transmitter. To mitigate the requirement for LGFU-induced cavitation, we propose LGFU configurations with a locally heated focal zone using an additional high-intensity focused ultrasound (HIFU) transmitter. After confirming heat-induced cavitation enhancement using two separate transmitters, we then developed a stacked hybrid optoacoustic-piezoelectric transmitter, which is a unique configuration made by coating an optoacoustic layer directly onto a piezoelectric substrate. This shared curvature design has great practical advantage without requiring the complex alignment of two focal zones. Moreover, this enabled the amplification of cavitation bubble density by 18.5-fold compared to the LGFU operation alone. Finally, the feasibility of tissue fragmentation was confirmed through a tissue-mimicking gel, using the combination of LGFU and HIFU (not via a stacked structure). We expect that the stacked transmitter can be effectively used for stronger and faster tissue fragmentation than the LGFU transmitter alone. |
format | Online Article Text |
id | pubmed-8540735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85407352021-10-24 Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation Sang, Pil Gyu Biswas, Deblina Lee, Seung Jin Won, Sang Min Son, Donghee Ok, Jong G. Park, Hui Joon Baac, Hyoung Won Micromachines (Basel) Article Laser-generated focused ultrasound (LGFU) is an emerging modality for cavitation-based therapy. However, focal pressure amplitudes by LGFU alone to achieve pulsed cavitation are often lacking as a treatment depth increases. This requires a higher pressure from a transmitter surface and more laser energies that even approach to a damage threshold of transmitter. To mitigate the requirement for LGFU-induced cavitation, we propose LGFU configurations with a locally heated focal zone using an additional high-intensity focused ultrasound (HIFU) transmitter. After confirming heat-induced cavitation enhancement using two separate transmitters, we then developed a stacked hybrid optoacoustic-piezoelectric transmitter, which is a unique configuration made by coating an optoacoustic layer directly onto a piezoelectric substrate. This shared curvature design has great practical advantage without requiring the complex alignment of two focal zones. Moreover, this enabled the amplification of cavitation bubble density by 18.5-fold compared to the LGFU operation alone. Finally, the feasibility of tissue fragmentation was confirmed through a tissue-mimicking gel, using the combination of LGFU and HIFU (not via a stacked structure). We expect that the stacked transmitter can be effectively used for stronger and faster tissue fragmentation than the LGFU transmitter alone. MDPI 2021-10-18 /pmc/articles/PMC8540735/ /pubmed/34683319 http://dx.doi.org/10.3390/mi12101268 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sang, Pil Gyu Biswas, Deblina Lee, Seung Jin Won, Sang Min Son, Donghee Ok, Jong G. Park, Hui Joon Baac, Hyoung Won Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation |
title | Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation |
title_full | Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation |
title_fullStr | Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation |
title_full_unstemmed | Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation |
title_short | Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation |
title_sort | experimental demonstration of a stacked hybrid optoacoustic-piezoelectric transducer for localized heating and enhanced cavitation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540735/ https://www.ncbi.nlm.nih.gov/pubmed/34683319 http://dx.doi.org/10.3390/mi12101268 |
work_keys_str_mv | AT sangpilgyu experimentaldemonstrationofastackedhybridoptoacousticpiezoelectrictransducerforlocalizedheatingandenhancedcavitation AT biswasdeblina experimentaldemonstrationofastackedhybridoptoacousticpiezoelectrictransducerforlocalizedheatingandenhancedcavitation AT leeseungjin experimentaldemonstrationofastackedhybridoptoacousticpiezoelectrictransducerforlocalizedheatingandenhancedcavitation AT wonsangmin experimentaldemonstrationofastackedhybridoptoacousticpiezoelectrictransducerforlocalizedheatingandenhancedcavitation AT sondonghee experimentaldemonstrationofastackedhybridoptoacousticpiezoelectrictransducerforlocalizedheatingandenhancedcavitation AT okjongg experimentaldemonstrationofastackedhybridoptoacousticpiezoelectrictransducerforlocalizedheatingandenhancedcavitation AT parkhuijoon experimentaldemonstrationofastackedhybridoptoacousticpiezoelectrictransducerforlocalizedheatingandenhancedcavitation AT baachyoungwon experimentaldemonstrationofastackedhybridoptoacousticpiezoelectrictransducerforlocalizedheatingandenhancedcavitation |