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Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation

Laser-generated focused ultrasound (LGFU) is an emerging modality for cavitation-based therapy. However, focal pressure amplitudes by LGFU alone to achieve pulsed cavitation are often lacking as a treatment depth increases. This requires a higher pressure from a transmitter surface and more laser en...

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Autores principales: Sang, Pil Gyu, Biswas, Deblina, Lee, Seung Jin, Won, Sang Min, Son, Donghee, Ok, Jong G., Park, Hui Joon, Baac, Hyoung Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540735/
https://www.ncbi.nlm.nih.gov/pubmed/34683319
http://dx.doi.org/10.3390/mi12101268
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author Sang, Pil Gyu
Biswas, Deblina
Lee, Seung Jin
Won, Sang Min
Son, Donghee
Ok, Jong G.
Park, Hui Joon
Baac, Hyoung Won
author_facet Sang, Pil Gyu
Biswas, Deblina
Lee, Seung Jin
Won, Sang Min
Son, Donghee
Ok, Jong G.
Park, Hui Joon
Baac, Hyoung Won
author_sort Sang, Pil Gyu
collection PubMed
description Laser-generated focused ultrasound (LGFU) is an emerging modality for cavitation-based therapy. However, focal pressure amplitudes by LGFU alone to achieve pulsed cavitation are often lacking as a treatment depth increases. This requires a higher pressure from a transmitter surface and more laser energies that even approach to a damage threshold of transmitter. To mitigate the requirement for LGFU-induced cavitation, we propose LGFU configurations with a locally heated focal zone using an additional high-intensity focused ultrasound (HIFU) transmitter. After confirming heat-induced cavitation enhancement using two separate transmitters, we then developed a stacked hybrid optoacoustic-piezoelectric transmitter, which is a unique configuration made by coating an optoacoustic layer directly onto a piezoelectric substrate. This shared curvature design has great practical advantage without requiring the complex alignment of two focal zones. Moreover, this enabled the amplification of cavitation bubble density by 18.5-fold compared to the LGFU operation alone. Finally, the feasibility of tissue fragmentation was confirmed through a tissue-mimicking gel, using the combination of LGFU and HIFU (not via a stacked structure). We expect that the stacked transmitter can be effectively used for stronger and faster tissue fragmentation than the LGFU transmitter alone.
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spelling pubmed-85407352021-10-24 Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation Sang, Pil Gyu Biswas, Deblina Lee, Seung Jin Won, Sang Min Son, Donghee Ok, Jong G. Park, Hui Joon Baac, Hyoung Won Micromachines (Basel) Article Laser-generated focused ultrasound (LGFU) is an emerging modality for cavitation-based therapy. However, focal pressure amplitudes by LGFU alone to achieve pulsed cavitation are often lacking as a treatment depth increases. This requires a higher pressure from a transmitter surface and more laser energies that even approach to a damage threshold of transmitter. To mitigate the requirement for LGFU-induced cavitation, we propose LGFU configurations with a locally heated focal zone using an additional high-intensity focused ultrasound (HIFU) transmitter. After confirming heat-induced cavitation enhancement using two separate transmitters, we then developed a stacked hybrid optoacoustic-piezoelectric transmitter, which is a unique configuration made by coating an optoacoustic layer directly onto a piezoelectric substrate. This shared curvature design has great practical advantage without requiring the complex alignment of two focal zones. Moreover, this enabled the amplification of cavitation bubble density by 18.5-fold compared to the LGFU operation alone. Finally, the feasibility of tissue fragmentation was confirmed through a tissue-mimicking gel, using the combination of LGFU and HIFU (not via a stacked structure). We expect that the stacked transmitter can be effectively used for stronger and faster tissue fragmentation than the LGFU transmitter alone. MDPI 2021-10-18 /pmc/articles/PMC8540735/ /pubmed/34683319 http://dx.doi.org/10.3390/mi12101268 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sang, Pil Gyu
Biswas, Deblina
Lee, Seung Jin
Won, Sang Min
Son, Donghee
Ok, Jong G.
Park, Hui Joon
Baac, Hyoung Won
Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation
title Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation
title_full Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation
title_fullStr Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation
title_full_unstemmed Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation
title_short Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitation
title_sort experimental demonstration of a stacked hybrid optoacoustic-piezoelectric transducer for localized heating and enhanced cavitation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540735/
https://www.ncbi.nlm.nih.gov/pubmed/34683319
http://dx.doi.org/10.3390/mi12101268
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