Cargando…
Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum)
Histoplasmosis is a severe mycotic disease affecting thousands of immunocompetent and immunocompromised individuals with high incidence in Latin America, where the disease agents are Histoplasma capsulatum and Histoplasma suramericanum. In this work, we used whole-genome sequencing to infer the spec...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540737/ https://www.ncbi.nlm.nih.gov/pubmed/34682286 http://dx.doi.org/10.3390/jof7100865 |
_version_ | 1784589059392274432 |
---|---|
author | Almeida-Silva, Fernando de Melo Teixeira, Marcus Matute, Daniel R. de Faria Ferreira, Marcela Barker, Bridget M. Almeida-Paes, Rodrigo Guimarães, Allan J. Zancopé-Oliveira, Rosely M. |
author_facet | Almeida-Silva, Fernando de Melo Teixeira, Marcus Matute, Daniel R. de Faria Ferreira, Marcela Barker, Bridget M. Almeida-Paes, Rodrigo Guimarães, Allan J. Zancopé-Oliveira, Rosely M. |
author_sort | Almeida-Silva, Fernando |
collection | PubMed |
description | Histoplasmosis is a severe mycotic disease affecting thousands of immunocompetent and immunocompromised individuals with high incidence in Latin America, where the disease agents are Histoplasma capsulatum and Histoplasma suramericanum. In this work, we used whole-genome sequencing to infer the species diversity and the population structure of H. suramericanum in South America. We find evidence for strong population structure and little admixture within the species. Genome-level phylogenetic trees indicate the existence of at least three different discrete populations. We recovered the existence of a previously identified population, LAmB, and confirm that it is highly differentiated along the whole genome. We also find that H. suramericanum is composed of two populations, one in Northern South America, and another in the southern portion of the continent. Moreover, one of the lineages from the southern population is endemic to Rio de Janeiro and there was no association with clinical data and species isolated from patients with histoplasmosis. Our results point out the need to characterize the symptomatology of histoplasmosis caused by different species and lineages of Histoplasma spp. |
format | Online Article Text |
id | pubmed-8540737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85407372021-10-24 Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum) Almeida-Silva, Fernando de Melo Teixeira, Marcus Matute, Daniel R. de Faria Ferreira, Marcela Barker, Bridget M. Almeida-Paes, Rodrigo Guimarães, Allan J. Zancopé-Oliveira, Rosely M. J Fungi (Basel) Article Histoplasmosis is a severe mycotic disease affecting thousands of immunocompetent and immunocompromised individuals with high incidence in Latin America, where the disease agents are Histoplasma capsulatum and Histoplasma suramericanum. In this work, we used whole-genome sequencing to infer the species diversity and the population structure of H. suramericanum in South America. We find evidence for strong population structure and little admixture within the species. Genome-level phylogenetic trees indicate the existence of at least three different discrete populations. We recovered the existence of a previously identified population, LAmB, and confirm that it is highly differentiated along the whole genome. We also find that H. suramericanum is composed of two populations, one in Northern South America, and another in the southern portion of the continent. Moreover, one of the lineages from the southern population is endemic to Rio de Janeiro and there was no association with clinical data and species isolated from patients with histoplasmosis. Our results point out the need to characterize the symptomatology of histoplasmosis caused by different species and lineages of Histoplasma spp. MDPI 2021-10-15 /pmc/articles/PMC8540737/ /pubmed/34682286 http://dx.doi.org/10.3390/jof7100865 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Almeida-Silva, Fernando de Melo Teixeira, Marcus Matute, Daniel R. de Faria Ferreira, Marcela Barker, Bridget M. Almeida-Paes, Rodrigo Guimarães, Allan J. Zancopé-Oliveira, Rosely M. Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum) |
title | Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum) |
title_full | Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum) |
title_fullStr | Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum) |
title_full_unstemmed | Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum) |
title_short | Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum) |
title_sort | genomic diversity analysis reveals a strong population structure in histoplasma capsulatum lama (histoplasma suramericanum) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540737/ https://www.ncbi.nlm.nih.gov/pubmed/34682286 http://dx.doi.org/10.3390/jof7100865 |
work_keys_str_mv | AT almeidasilvafernando genomicdiversityanalysisrevealsastrongpopulationstructureinhistoplasmacapsulatumlamahistoplasmasuramericanum AT demeloteixeiramarcus genomicdiversityanalysisrevealsastrongpopulationstructureinhistoplasmacapsulatumlamahistoplasmasuramericanum AT matutedanielr genomicdiversityanalysisrevealsastrongpopulationstructureinhistoplasmacapsulatumlamahistoplasmasuramericanum AT defariaferreiramarcela genomicdiversityanalysisrevealsastrongpopulationstructureinhistoplasmacapsulatumlamahistoplasmasuramericanum AT barkerbridgetm genomicdiversityanalysisrevealsastrongpopulationstructureinhistoplasmacapsulatumlamahistoplasmasuramericanum AT almeidapaesrodrigo genomicdiversityanalysisrevealsastrongpopulationstructureinhistoplasmacapsulatumlamahistoplasmasuramericanum AT guimaraesallanj genomicdiversityanalysisrevealsastrongpopulationstructureinhistoplasmacapsulatumlamahistoplasmasuramericanum AT zancopeoliveiraroselym genomicdiversityanalysisrevealsastrongpopulationstructureinhistoplasmacapsulatumlamahistoplasmasuramericanum |