Cargando…

Anti-Proliferative, Anti-Angiogenic and Safety Profiles of Novel HDAC Inhibitors for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Metastatic castration-resistant prostate cancer (CRPC) has a five-year survival rate of 28%. As histone deacetylases (HDACs) are overexpressed in CRPC, the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) was trialled in CRPC patients but found to be toxic and inefficacious. Previously, we show...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rana, Zohaib, Diermeier, Sarah, Walsh, Fearghal P., Hanif, Muhammad, Hartinger, Christian G., Rosengren, Rhonda J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540814/ https://www.ncbi.nlm.nih.gov/pubmed/34681244 http://dx.doi.org/10.3390/ph14101020

Ejemplares similares

Understanding Failure and Improving Treatment Using HDAC Inhibitors for Prostate Cancer
por: Rana, Zohaib, et al.
Publicado: (2020)

Cytostatic Action of Novel Histone Deacetylase Inhibitors in Androgen Receptor-Null Prostate Cancer Cells
por: Rana, Zohaib, et al.
Publicado: (2021)

Exploring the Mechanism and Suggesting Combination Therapies for HDAC Inhibitors in Androgen Receptor-Null Prostate Cancer Using Multivariate Statistical Analysis and Data Mining Techniques
por: Rana, Zohaib, et al.
Publicado: (2022)

Raloxifene Suppresses Tumor Growth and Metastasis in an Orthotopic Model of Castration-Resistant Prostate Cancer
por: Palmer, Hannah, et al.
Publicado: (2022)

High Antiproliferative Activity of Hydroxythiopyridones over Hydroxypyridones and Their Organoruthenium Complexes
por: Shakil, Md. Salman, et al.
Publicado: (2021)

The Anti-Angiogenic and Anti-Proliferative Activity of Methyl Hydroxychalcone
por: Sahib, Hayder B
Publicado: (2022)

Anti-Angiogenic and Anti-Proliferative Graphene Oxide Nanosheets for Tumor Cell Therapy
por: Verde, Valeria, et al.
Publicado: (2020)

Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone-Induced Benign Prostatic Hyperplasia in Rats
por: Al Zoubi, Mazhar Salim, et al.
Publicado: (2022)

Anti-angiogenic and anti-proliferative effects of Benja-ummarit extract in rats with hepatocellular carcinoma
por: Kaewnoonual, Nattpawit, et al.
Publicado: (2020)

Anti-Angiogenic and Anti-Metastatic Activity of Synthetic Phosphoethanolamine
por: Ferreira, Adilson Kleber, et al.
Publicado: (2013)

HDAC Inhibition Impedes Epithelial-Mesenchymal Plasticity and Suppresses Metastatic, Castration-Resistant Prostate Cancer
por: Ruscetti, Marcus, et al.
Publicado: (2015)

Methanolic extract of Euchelus asper exhibits in-ovo anti-angiogenic and in vitro anti-proliferative activities
por: Agrawal, Sweta, et al.
Publicado: (2017)

Investigation of anti-proliferative and anti-angiogenic properties of Parkia javanica bark and fruit extracts in zebrafish
por: Dhakal, Rasik, et al.
Publicado: (2023)

A Novel Role for Raloxifene Nanomicelles in Management of Castrate Resistant Prostate Cancer
por: Taurin, Sebastien, et al.
Publicado: (2014)

Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcoma
por: Canter, Robert J, et al.
Publicado: (2014)

A combination of sorafenib and nilotinib reduces the growth of castrate-resistant prostate cancer
por: Archibald, Monica, et al.
Publicado: (2016)

An Insight into the Anti-Angiogenic and Anti-Metastatic Effects of Oridonin: Current Knowledge and Future Potential
por: Abdullah, Nurul Akmaryanti, et al.
Publicado: (2021)

Resistance Mechanisms of the Metastatic Tumor Microenvironment to Anti-Angiogenic Therapy
por: Schiffmann, Lars M., et al.
Publicado: (2022)

HDAC inhibitors with potential to overcome drug resistance in castration-resistant prostate cancer
por: Biersack, Bernhard, et al.
Publicado: (2022)

Combining EZH2 and HDAC inhibitors to target castration-resistant prostate cancers
por: Coulter, Jonathan B., et al.
Publicado: (2023)

Efficacy and Safety of Docetaxel in Elderly Patients With Metastatic Castration-Resistant Prostate Cancer
por: Maia, Manuel Caitano, et al.
Publicado: (2017)

Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients
por: Vaishampayan, Ulka, et al.
Publicado: (2015)

Clinical Implication of Anti-Angiogenic Effect of Regorafenib in Metastatic Colorectal Cancer
por: Lim, Yoojoo, et al.
Publicado: (2015)

Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies
por: García, Santiago, et al.
Publicado: (2020)

Dihydropyrazole-Carbohydrazide Derivatives with Dual Activity as Antioxidant and Anti-Proliferative Drugs on Breast Cancer Targeting the HDAC6
por: Balbuena-Rebolledo, Irving, et al.
Publicado: (2022)

Utilization and Outcomes of Surgical Castration in Comparison to Medical Castration in Metastatic Prostate Cancer
por: Garje, Rohan, et al.
Publicado: (2019)

Proliferative diabetic retinopathy transcriptomes reveal angiogenesis, anti-angiogenic therapy escape mechanisms, fibrosis and lymphatic involvement
por: Korhonen, Ani, et al.
Publicado: (2021)

Anti-Metastatic and Anti-Angiogenic Effects of Curcumin Analog DK1 on Human Osteosarcoma Cells In Vitro
por: Aziz, Muhammad Nazirul Mubin, et al.
Publicado: (2021)

Meta-analysis of efficacy and safety of custirsen in patients with metastatic castration-resistant prostate cancer
por: Zhang, Xuebao, et al.
Publicado: (2019)

Angiogenic signaling pathways and anti-angiogenic therapy for cancer
por: Liu, Zhen-Ling, et al.
Publicado: (2023)

HDAC3-mediated silencing of miR-451 decreases chemosensitivity of patients with metastatic castration-resistant prostate cancer by targeting NEDD9
por: Chen, Dong-qin, et al.
Publicado: (2018)

Combating castration-resistant prostate cancer by co-targeting the epigenetic regulators EZH2 and HDAC
por: Schade, Amy E., et al.
Publicado: (2023)

Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic
por: Xia, Qing-Hai, et al.
Publicado: (2021)

Anti-angiogenic and anti-proliferative activity of ziziphus leaf extract as a novel potential therapeutic agent for reducing hepatic injury in experimental hamster schistosomiasis
por: Alghamdi, Thamer, et al.
Publicado: (2023)

Anti-tumor and anti-angiogenic effects of Fucoidan on prostate cancer: possible JAK-STAT3 pathway
por: Rui, Xin, et al.
Publicado: (2017)

Anti-proliferative effects of qianliening capsules on prostatic hyperplasia in vitro and in vivo
por: ZHONG, XIAOYONG, et al.
Publicado: (2015)

Anti-proliferative and pro-apoptotic effects of GHRH antagonists in prostate cancer
por: Muñoz-Moreno, Laura, et al.
Publicado: (2016)

Anti-Proliferative Effects of HBX-5 on Progression of Benign Prostatic Hyperplasia
por: Jin, Bo-Ram, et al.
Publicado: (2018)

Decrease of Pro-Angiogenic Monocytes Predicts Clinical Response to Anti-Angiogenic Treatment in Patients with Metastatic Renal Cell Carcinoma
por: Oudard, Stephane, et al.
Publicado: (2021)

Impact of Time to Castration Resistance on Cytoreductive Radiotherapy in Metastatic Castration-Resistant Prostate Cancer
por: Mai, Lixin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_69v63segpgtj41oqe76jj59k7e