IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives

Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways...

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Autores principales: Španko, Michal, Strnadová, Karolína, Pavlíček, Aleš Jan, Szabo, Pavol, Kodet, Ondřej, Valach, Jaroslav, Dvořánková, Barbora, Smetana, Karel, Lacina, Lukáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540903/
https://www.ncbi.nlm.nih.gov/pubmed/34681685
http://dx.doi.org/10.3390/ijms222011027
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author Španko, Michal
Strnadová, Karolína
Pavlíček, Aleš Jan
Szabo, Pavol
Kodet, Ondřej
Valach, Jaroslav
Dvořánková, Barbora
Smetana, Karel
Lacina, Lukáš
author_facet Španko, Michal
Strnadová, Karolína
Pavlíček, Aleš Jan
Szabo, Pavol
Kodet, Ondřej
Valach, Jaroslav
Dvořánková, Barbora
Smetana, Karel
Lacina, Lukáš
author_sort Španko, Michal
collection PubMed
description Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.
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spelling pubmed-85409032021-10-24 IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives Španko, Michal Strnadová, Karolína Pavlíček, Aleš Jan Szabo, Pavol Kodet, Ondřej Valach, Jaroslav Dvořánková, Barbora Smetana, Karel Lacina, Lukáš Int J Mol Sci Review Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer. MDPI 2021-10-13 /pmc/articles/PMC8540903/ /pubmed/34681685 http://dx.doi.org/10.3390/ijms222011027 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Španko, Michal
Strnadová, Karolína
Pavlíček, Aleš Jan
Szabo, Pavol
Kodet, Ondřej
Valach, Jaroslav
Dvořánková, Barbora
Smetana, Karel
Lacina, Lukáš
IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives
title IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives
title_full IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives
title_fullStr IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives
title_full_unstemmed IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives
title_short IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives
title_sort il-6 in the ecosystem of head and neck cancer: possible therapeutic perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540903/
https://www.ncbi.nlm.nih.gov/pubmed/34681685
http://dx.doi.org/10.3390/ijms222011027
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