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An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing

Presbyopia is a common eye disorder among aged people which is attributed to the loss of accommodation of the crystalline lens due to the increasing stiffness. One of the potential techniques to correct presbyopia involves removing the lens substance inside the capsule and replacing it with an artif...

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Autores principales: Wei, Huidong, Wolffsohn, James S., Gomes de Oliveira, Otavio, Davies, Leon N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540979/
https://www.ncbi.nlm.nih.gov/pubmed/34685312
http://dx.doi.org/10.3390/polym13203552
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author Wei, Huidong
Wolffsohn, James S.
Gomes de Oliveira, Otavio
Davies, Leon N.
author_facet Wei, Huidong
Wolffsohn, James S.
Gomes de Oliveira, Otavio
Davies, Leon N.
author_sort Wei, Huidong
collection PubMed
description Presbyopia is a common eye disorder among aged people which is attributed to the loss of accommodation of the crystalline lens due to the increasing stiffness. One of the potential techniques to correct presbyopia involves removing the lens substance inside the capsule and replacing it with an artificial lens. The development of such devices, e.g., accommodating intraocular lenses (AIOLs), relies on the understanding of the biomechanical behaviour of the lens capsule and the essential design verification ex vivo. To mimic the eye’s dynamic focusing ability (accommodation), an artificial lens capsule (ALC), from silicone rubber accompanied by a lens radial stretching system (LRSS) was developed. The ALC was manufactured to offer a dimension and deforming behaviour replicating the human lens capsule. The LRSS was calibrated to provide a radial stretch simulating the change of diameter of capsules during accommodating process. The biomechanical function of the ALC was addressed by studying its evolution behaviour and reaction force under multiaxial stretch from the LRSS. The study highlighted the convenience of this application by performing preliminary tests on prototypes of ophthalmic devices (e.g., AIOLs) to restore accommodation.
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spelling pubmed-85409792021-10-24 An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing Wei, Huidong Wolffsohn, James S. Gomes de Oliveira, Otavio Davies, Leon N. Polymers (Basel) Article Presbyopia is a common eye disorder among aged people which is attributed to the loss of accommodation of the crystalline lens due to the increasing stiffness. One of the potential techniques to correct presbyopia involves removing the lens substance inside the capsule and replacing it with an artificial lens. The development of such devices, e.g., accommodating intraocular lenses (AIOLs), relies on the understanding of the biomechanical behaviour of the lens capsule and the essential design verification ex vivo. To mimic the eye’s dynamic focusing ability (accommodation), an artificial lens capsule (ALC), from silicone rubber accompanied by a lens radial stretching system (LRSS) was developed. The ALC was manufactured to offer a dimension and deforming behaviour replicating the human lens capsule. The LRSS was calibrated to provide a radial stretch simulating the change of diameter of capsules during accommodating process. The biomechanical function of the ALC was addressed by studying its evolution behaviour and reaction force under multiaxial stretch from the LRSS. The study highlighted the convenience of this application by performing preliminary tests on prototypes of ophthalmic devices (e.g., AIOLs) to restore accommodation. MDPI 2021-10-15 /pmc/articles/PMC8540979/ /pubmed/34685312 http://dx.doi.org/10.3390/polym13203552 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wei, Huidong
Wolffsohn, James S.
Gomes de Oliveira, Otavio
Davies, Leon N.
An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing
title An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing
title_full An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing
title_fullStr An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing
title_full_unstemmed An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing
title_short An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing
title_sort artificial lens capsule with a lens radial stretching system mimicking dynamic eye focusing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540979/
https://www.ncbi.nlm.nih.gov/pubmed/34685312
http://dx.doi.org/10.3390/polym13203552
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