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PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of...

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Detalles Bibliográficos
Autores principales: Kim, Se Min, Patel, Madhumita, Patel, Rajkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540999/
https://www.ncbi.nlm.nih.gov/pubmed/34685230
http://dx.doi.org/10.3390/polym13203471
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author Kim, Se Min
Patel, Madhumita
Patel, Rajkumar
author_facet Kim, Se Min
Patel, Madhumita
Patel, Rajkumar
author_sort Kim, Se Min
collection PubMed
description Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of sequence-controlled release and provide protection of drugs. Among other biomedical polymers, poly (lactic-co-glycolic acid) (PLGA), a food and drug administration (FDA)-approved polymer, has been recognized for the vehicle material. This review introduces PLGA core–shell nano/microparticles and summarizes various drug-delivery systems based on these particles for cancer therapy and tissue regeneration. Tissue regeneration mainly includes bone, cartilage, and periodontal regeneration.
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spelling pubmed-85409992021-10-24 PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application Kim, Se Min Patel, Madhumita Patel, Rajkumar Polymers (Basel) Review Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of sequence-controlled release and provide protection of drugs. Among other biomedical polymers, poly (lactic-co-glycolic acid) (PLGA), a food and drug administration (FDA)-approved polymer, has been recognized for the vehicle material. This review introduces PLGA core–shell nano/microparticles and summarizes various drug-delivery systems based on these particles for cancer therapy and tissue regeneration. Tissue regeneration mainly includes bone, cartilage, and periodontal regeneration. MDPI 2021-10-10 /pmc/articles/PMC8540999/ /pubmed/34685230 http://dx.doi.org/10.3390/polym13203471 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Se Min
Patel, Madhumita
Patel, Rajkumar
PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
title PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
title_full PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
title_fullStr PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
title_full_unstemmed PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
title_short PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
title_sort plga core-shell nano/microparticle delivery system for biomedical application
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540999/
https://www.ncbi.nlm.nih.gov/pubmed/34685230
http://dx.doi.org/10.3390/polym13203471
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