Hodgkin Lymphoma: A Special Microenvironment

Classical Hodgkin’s lymphoma (cHL) is one of the most particular lymphomas for the few tumor cells surrounded by an inflammatory microenvironment. Reed-Sternberg (RS) and Hodgkin (H) cells reprogram and evade antitumor mechanisms of the normal cells present in the microenvironment. The cells of micr...

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Autores principales: Opinto, Giuseppina, Agostinelli, Claudio, Ciavarella, Sabino, Guarini, Attilio, Maiorano, Eugenio, Ingravallo, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541076/
https://www.ncbi.nlm.nih.gov/pubmed/34682791
http://dx.doi.org/10.3390/jcm10204665
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author Opinto, Giuseppina
Agostinelli, Claudio
Ciavarella, Sabino
Guarini, Attilio
Maiorano, Eugenio
Ingravallo, Giuseppe
author_facet Opinto, Giuseppina
Agostinelli, Claudio
Ciavarella, Sabino
Guarini, Attilio
Maiorano, Eugenio
Ingravallo, Giuseppe
author_sort Opinto, Giuseppina
collection PubMed
description Classical Hodgkin’s lymphoma (cHL) is one of the most particular lymphomas for the few tumor cells surrounded by an inflammatory microenvironment. Reed-Sternberg (RS) and Hodgkin (H) cells reprogram and evade antitumor mechanisms of the normal cells present in the microenvironment. The cells of microenvironment are essential for growth and survival of the RS/H cells and are recruited through the effect of cytokines/chemokines. We summarize recent advances in gene expression profiling (GEP) analysis applied to study microenvironment component in cHL. We also describe the main therapies that target not only the neoplastic cells but also the cellular components of the background.
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spelling pubmed-85410762021-10-24 Hodgkin Lymphoma: A Special Microenvironment Opinto, Giuseppina Agostinelli, Claudio Ciavarella, Sabino Guarini, Attilio Maiorano, Eugenio Ingravallo, Giuseppe J Clin Med Review Classical Hodgkin’s lymphoma (cHL) is one of the most particular lymphomas for the few tumor cells surrounded by an inflammatory microenvironment. Reed-Sternberg (RS) and Hodgkin (H) cells reprogram and evade antitumor mechanisms of the normal cells present in the microenvironment. The cells of microenvironment are essential for growth and survival of the RS/H cells and are recruited through the effect of cytokines/chemokines. We summarize recent advances in gene expression profiling (GEP) analysis applied to study microenvironment component in cHL. We also describe the main therapies that target not only the neoplastic cells but also the cellular components of the background. MDPI 2021-10-12 /pmc/articles/PMC8541076/ /pubmed/34682791 http://dx.doi.org/10.3390/jcm10204665 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Opinto, Giuseppina
Agostinelli, Claudio
Ciavarella, Sabino
Guarini, Attilio
Maiorano, Eugenio
Ingravallo, Giuseppe
Hodgkin Lymphoma: A Special Microenvironment
title Hodgkin Lymphoma: A Special Microenvironment
title_full Hodgkin Lymphoma: A Special Microenvironment
title_fullStr Hodgkin Lymphoma: A Special Microenvironment
title_full_unstemmed Hodgkin Lymphoma: A Special Microenvironment
title_short Hodgkin Lymphoma: A Special Microenvironment
title_sort hodgkin lymphoma: a special microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541076/
https://www.ncbi.nlm.nih.gov/pubmed/34682791
http://dx.doi.org/10.3390/jcm10204665
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