Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers

Cancer, as the second leading cause of death worldwide, is a major public health concern that imposes a heavy social and economic burden. Effective approaches for either diagnosis or therapy of most cancers are still lacking. Dynamic monitoring and personalized therapy are the main directions for ca...

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Autores principales: Wang, Yi, Zhao, Ruichen, Jiao, Xueqiao, Wu, Longyuan, Wei, Yuxuan, Shi, Fuxiu, Zhong, Junpei, Xiong, Lixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541078/
https://www.ncbi.nlm.nih.gov/pubmed/34685415
http://dx.doi.org/10.3390/life11101044
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author Wang, Yi
Zhao, Ruichen
Jiao, Xueqiao
Wu, Longyuan
Wei, Yuxuan
Shi, Fuxiu
Zhong, Junpei
Xiong, Lixia
author_facet Wang, Yi
Zhao, Ruichen
Jiao, Xueqiao
Wu, Longyuan
Wei, Yuxuan
Shi, Fuxiu
Zhong, Junpei
Xiong, Lixia
author_sort Wang, Yi
collection PubMed
description Cancer, as the second leading cause of death worldwide, is a major public health concern that imposes a heavy social and economic burden. Effective approaches for either diagnosis or therapy of most cancers are still lacking. Dynamic monitoring and personalized therapy are the main directions for cancer research. Cancer-derived extracellular vesicles (EVs) are potential disease biomarkers. Cancer EVs, including small EVs (sEVs), contain unique biomolecules (protein, nucleic acid, and lipids) at various stages of carcinogenesis. In this review, we discuss the biogenesis of sEVs, and their functions in cancer, revealing the potential applications of sEVs as cancer biomarkers.
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spelling pubmed-85410782021-10-24 Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers Wang, Yi Zhao, Ruichen Jiao, Xueqiao Wu, Longyuan Wei, Yuxuan Shi, Fuxiu Zhong, Junpei Xiong, Lixia Life (Basel) Review Cancer, as the second leading cause of death worldwide, is a major public health concern that imposes a heavy social and economic burden. Effective approaches for either diagnosis or therapy of most cancers are still lacking. Dynamic monitoring and personalized therapy are the main directions for cancer research. Cancer-derived extracellular vesicles (EVs) are potential disease biomarkers. Cancer EVs, including small EVs (sEVs), contain unique biomolecules (protein, nucleic acid, and lipids) at various stages of carcinogenesis. In this review, we discuss the biogenesis of sEVs, and their functions in cancer, revealing the potential applications of sEVs as cancer biomarkers. MDPI 2021-10-04 /pmc/articles/PMC8541078/ /pubmed/34685415 http://dx.doi.org/10.3390/life11101044 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Yi
Zhao, Ruichen
Jiao, Xueqiao
Wu, Longyuan
Wei, Yuxuan
Shi, Fuxiu
Zhong, Junpei
Xiong, Lixia
Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers
title Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers
title_full Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers
title_fullStr Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers
title_full_unstemmed Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers
title_short Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers
title_sort small extracellular vesicles: functions and potential clinical applications as cancer biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541078/
https://www.ncbi.nlm.nih.gov/pubmed/34685415
http://dx.doi.org/10.3390/life11101044
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