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Simulation of Onset of the Capillary Surface Wave in the Ultrasonic Atomizer
The novel drug delivery system refers to the formulations and technologies for transporting a pharmaceutical compound in the body as it is needed to safely achieve its desired therapeutic effects. In this study, the onset vibrational amplitude of capillary surface waves for ultrasonic atomization sp...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541093/ https://www.ncbi.nlm.nih.gov/pubmed/34683197 http://dx.doi.org/10.3390/mi12101146 |
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author | Song, Yu-Lin Cheng, Chih-Hsiao Reddy, Manoj Kumar Islam, Md Saikhul |
author_facet | Song, Yu-Lin Cheng, Chih-Hsiao Reddy, Manoj Kumar Islam, Md Saikhul |
author_sort | Song, Yu-Lin |
collection | PubMed |
description | The novel drug delivery system refers to the formulations and technologies for transporting a pharmaceutical compound in the body as it is needed to safely achieve its desired therapeutic effects. In this study, the onset vibrational amplitude of capillary surface waves for ultrasonic atomization spray is explained based on Faraday instability. Using ultrasonic frequency, the vibrational amplitude approached a critical point, and the liquid surface broke up into tiny drops. The micro-droplets were are steadily and continuously formed after the liquid feeding rate was optimized. The simulation study reported a minimum vibrational amplitude or onset value of 0.38 μm at 500 kHz frequency. The required minimum energy to atomize the drops was simulated by COMSOL Multiphysics simulation software. The simulation result agreed well with the numerical results of a subharmonic vibrational model that ocurred at 250 kHz frequency on the liquid surface. This newly designed single frequency ultrasonic atomizer showed its true physical characteristic of resonance on the fluid surface plane. Hence, this research will contribute to the future development of a single-frequency ultrasonic nebulizer and mechatronics for the generation of uniform atomized droplets. |
format | Online Article Text |
id | pubmed-8541093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85410932021-10-24 Simulation of Onset of the Capillary Surface Wave in the Ultrasonic Atomizer Song, Yu-Lin Cheng, Chih-Hsiao Reddy, Manoj Kumar Islam, Md Saikhul Micromachines (Basel) Article The novel drug delivery system refers to the formulations and technologies for transporting a pharmaceutical compound in the body as it is needed to safely achieve its desired therapeutic effects. In this study, the onset vibrational amplitude of capillary surface waves for ultrasonic atomization spray is explained based on Faraday instability. Using ultrasonic frequency, the vibrational amplitude approached a critical point, and the liquid surface broke up into tiny drops. The micro-droplets were are steadily and continuously formed after the liquid feeding rate was optimized. The simulation study reported a minimum vibrational amplitude or onset value of 0.38 μm at 500 kHz frequency. The required minimum energy to atomize the drops was simulated by COMSOL Multiphysics simulation software. The simulation result agreed well with the numerical results of a subharmonic vibrational model that ocurred at 250 kHz frequency on the liquid surface. This newly designed single frequency ultrasonic atomizer showed its true physical characteristic of resonance on the fluid surface plane. Hence, this research will contribute to the future development of a single-frequency ultrasonic nebulizer and mechatronics for the generation of uniform atomized droplets. MDPI 2021-09-23 /pmc/articles/PMC8541093/ /pubmed/34683197 http://dx.doi.org/10.3390/mi12101146 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Song, Yu-Lin Cheng, Chih-Hsiao Reddy, Manoj Kumar Islam, Md Saikhul Simulation of Onset of the Capillary Surface Wave in the Ultrasonic Atomizer |
title | Simulation of Onset of the Capillary Surface Wave in the Ultrasonic Atomizer |
title_full | Simulation of Onset of the Capillary Surface Wave in the Ultrasonic Atomizer |
title_fullStr | Simulation of Onset of the Capillary Surface Wave in the Ultrasonic Atomizer |
title_full_unstemmed | Simulation of Onset of the Capillary Surface Wave in the Ultrasonic Atomizer |
title_short | Simulation of Onset of the Capillary Surface Wave in the Ultrasonic Atomizer |
title_sort | simulation of onset of the capillary surface wave in the ultrasonic atomizer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541093/ https://www.ncbi.nlm.nih.gov/pubmed/34683197 http://dx.doi.org/10.3390/mi12101146 |
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