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Risk Factors and Outcomes of Hospital Acquired Pneumonia in Young Bangladeshi Children

Hospital acquired pneumonia (HAP) is common and often associated with high mortality in children aged five or less. We sought to evaluate the risk factors and outcome of HAP in such children. We compared demographic, clinical, and laboratory characteristics in children <5 years using a case contr...

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Autores principales: Shahid, Abu Sadat Mohammad Sayeem Bin, Alam, Tahmina, Shahrin, Lubaba, Shahunja, K. M., Faruk, Md. Tanveer, Ackhter, Mst. Mahmuda, Karim, Ishrat Jahan, Islam, Shafiul, Ahmed, Mostafa Taufiq, Saha, Haimanti, Parvin, Irin, Ahmed, Tahmeed, Chisti, Mohammod Jobayer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541107/
https://www.ncbi.nlm.nih.gov/pubmed/34685401
http://dx.doi.org/10.3390/life11101030
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author Shahid, Abu Sadat Mohammad Sayeem Bin
Alam, Tahmina
Shahrin, Lubaba
Shahunja, K. M.
Faruk, Md. Tanveer
Ackhter, Mst. Mahmuda
Karim, Ishrat Jahan
Islam, Shafiul
Ahmed, Mostafa Taufiq
Saha, Haimanti
Parvin, Irin
Ahmed, Tahmeed
Chisti, Mohammod Jobayer
author_facet Shahid, Abu Sadat Mohammad Sayeem Bin
Alam, Tahmina
Shahrin, Lubaba
Shahunja, K. M.
Faruk, Md. Tanveer
Ackhter, Mst. Mahmuda
Karim, Ishrat Jahan
Islam, Shafiul
Ahmed, Mostafa Taufiq
Saha, Haimanti
Parvin, Irin
Ahmed, Tahmeed
Chisti, Mohammod Jobayer
author_sort Shahid, Abu Sadat Mohammad Sayeem Bin
collection PubMed
description Hospital acquired pneumonia (HAP) is common and often associated with high mortality in children aged five or less. We sought to evaluate the risk factors and outcome of HAP in such children. We compared demographic, clinical, and laboratory characteristics in children <5 years using a case control design during the period of August 2013 and December 2017, where children with HAP were constituted as cases (n = 281) and twice as many randomly selected children without HAP were constituted as controls (n = 562). HAP was defined as a child developing a new episode of pneumonia both clinically and radiologically after at least 48 h of hospitalization. A total of 4101 children were treated during the study period. The mortality was significantly higher among the cases than the controls (8% vs. 4%, p = 0.014). In multivariate logistic regression analysis, after adjusting for potential confounders, it was found that persistent diarrhea (95% CI = 1.32–5.79; p = 0.007), severe acute malnutrition (95% CI = 1.46–3.27; p < 0.001), bacteremia (95% CI = 1.16–3.49; p = 0.013), and prolonged hospitalization of >5 days (95% CI = 3.01–8.02; p < 0.001) were identified as independent risk factors for HAP. Early identification of these risk factors and their prompt management may help to reduce HAP-related fatal consequences, especially in resource limited settings.
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spelling pubmed-85411072021-10-24 Risk Factors and Outcomes of Hospital Acquired Pneumonia in Young Bangladeshi Children Shahid, Abu Sadat Mohammad Sayeem Bin Alam, Tahmina Shahrin, Lubaba Shahunja, K. M. Faruk, Md. Tanveer Ackhter, Mst. Mahmuda Karim, Ishrat Jahan Islam, Shafiul Ahmed, Mostafa Taufiq Saha, Haimanti Parvin, Irin Ahmed, Tahmeed Chisti, Mohammod Jobayer Life (Basel) Article Hospital acquired pneumonia (HAP) is common and often associated with high mortality in children aged five or less. We sought to evaluate the risk factors and outcome of HAP in such children. We compared demographic, clinical, and laboratory characteristics in children <5 years using a case control design during the period of August 2013 and December 2017, where children with HAP were constituted as cases (n = 281) and twice as many randomly selected children without HAP were constituted as controls (n = 562). HAP was defined as a child developing a new episode of pneumonia both clinically and radiologically after at least 48 h of hospitalization. A total of 4101 children were treated during the study period. The mortality was significantly higher among the cases than the controls (8% vs. 4%, p = 0.014). In multivariate logistic regression analysis, after adjusting for potential confounders, it was found that persistent diarrhea (95% CI = 1.32–5.79; p = 0.007), severe acute malnutrition (95% CI = 1.46–3.27; p < 0.001), bacteremia (95% CI = 1.16–3.49; p = 0.013), and prolonged hospitalization of >5 days (95% CI = 3.01–8.02; p < 0.001) were identified as independent risk factors for HAP. Early identification of these risk factors and their prompt management may help to reduce HAP-related fatal consequences, especially in resource limited settings. MDPI 2021-09-30 /pmc/articles/PMC8541107/ /pubmed/34685401 http://dx.doi.org/10.3390/life11101030 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shahid, Abu Sadat Mohammad Sayeem Bin
Alam, Tahmina
Shahrin, Lubaba
Shahunja, K. M.
Faruk, Md. Tanveer
Ackhter, Mst. Mahmuda
Karim, Ishrat Jahan
Islam, Shafiul
Ahmed, Mostafa Taufiq
Saha, Haimanti
Parvin, Irin
Ahmed, Tahmeed
Chisti, Mohammod Jobayer
Risk Factors and Outcomes of Hospital Acquired Pneumonia in Young Bangladeshi Children
title Risk Factors and Outcomes of Hospital Acquired Pneumonia in Young Bangladeshi Children
title_full Risk Factors and Outcomes of Hospital Acquired Pneumonia in Young Bangladeshi Children
title_fullStr Risk Factors and Outcomes of Hospital Acquired Pneumonia in Young Bangladeshi Children
title_full_unstemmed Risk Factors and Outcomes of Hospital Acquired Pneumonia in Young Bangladeshi Children
title_short Risk Factors and Outcomes of Hospital Acquired Pneumonia in Young Bangladeshi Children
title_sort risk factors and outcomes of hospital acquired pneumonia in young bangladeshi children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541107/
https://www.ncbi.nlm.nih.gov/pubmed/34685401
http://dx.doi.org/10.3390/life11101030
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