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Mapping of Chronic Pulmonary Aspergillosis in Africa

Africa has a high burden of tuberculosis, which is the most important risk factor for chronic pulmonary aspergillosis (CPA). Our goal was to systematically evaluate the burden of CPA in Africa and map it by country. We conducted an extensive literature search for publications on CPA in Africa using...

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Autores principales: Olum, Ronald, Osaigbovo, Iriagbonse Iyabo, Baluku, Joseph Baruch, Stemler, Jannik, Kwizera, Richard, Bongomin, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541146/
https://www.ncbi.nlm.nih.gov/pubmed/34682212
http://dx.doi.org/10.3390/jof7100790
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author Olum, Ronald
Osaigbovo, Iriagbonse Iyabo
Baluku, Joseph Baruch
Stemler, Jannik
Kwizera, Richard
Bongomin, Felix
author_facet Olum, Ronald
Osaigbovo, Iriagbonse Iyabo
Baluku, Joseph Baruch
Stemler, Jannik
Kwizera, Richard
Bongomin, Felix
author_sort Olum, Ronald
collection PubMed
description Africa has a high burden of tuberculosis, which is the most important risk factor for chronic pulmonary aspergillosis (CPA). Our goal was to systematically evaluate the burden of CPA in Africa and map it by country. We conducted an extensive literature search for publications on CPA in Africa using the online databases. We reviewed a total of 41 studies published between 1976 and 2021, including a total of 1247 CPA cases from 14 African countries. Most of the cases came from Morocco (n = 764, 62.3%), followed by South Africa (n = 122, 9.9%) and Senegal (n = 99, 8.1%). Seventeen (41.5%) studies were retrospective, 12 (29.3%) were case reports, 5 case series (12.2%), 5 prospective cohorts, and 2 cross-sectional studies. The majority of the cases (67.1%, n = 645) were diagnosed in men, with a median age of 41 years (interquartile range: 36–45). Active/previously treated pulmonary tuberculosis (n = 764, 61.3%), human immunodeficiency virus infection (n = 29, 2.3%), diabetes mellitus (n = 19, 1.5%), and chronic obstructive pulmonary disease (n = 10, 0.8%) were the common co-morbidities. Haemoptysis was the most frequent presenting symptom, reported in up to 717 (57%) cases. Smoking (n = 69, 5.5%), recurrent lung infections (n = 41, 3%) and bronchorrhea (n = 33, 3%) were noted. This study confirms that CPA is common in Africa, with pulmonary tuberculosis being the most important risk factor.
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spelling pubmed-85411462021-10-24 Mapping of Chronic Pulmonary Aspergillosis in Africa Olum, Ronald Osaigbovo, Iriagbonse Iyabo Baluku, Joseph Baruch Stemler, Jannik Kwizera, Richard Bongomin, Felix J Fungi (Basel) Article Africa has a high burden of tuberculosis, which is the most important risk factor for chronic pulmonary aspergillosis (CPA). Our goal was to systematically evaluate the burden of CPA in Africa and map it by country. We conducted an extensive literature search for publications on CPA in Africa using the online databases. We reviewed a total of 41 studies published between 1976 and 2021, including a total of 1247 CPA cases from 14 African countries. Most of the cases came from Morocco (n = 764, 62.3%), followed by South Africa (n = 122, 9.9%) and Senegal (n = 99, 8.1%). Seventeen (41.5%) studies were retrospective, 12 (29.3%) were case reports, 5 case series (12.2%), 5 prospective cohorts, and 2 cross-sectional studies. The majority of the cases (67.1%, n = 645) were diagnosed in men, with a median age of 41 years (interquartile range: 36–45). Active/previously treated pulmonary tuberculosis (n = 764, 61.3%), human immunodeficiency virus infection (n = 29, 2.3%), diabetes mellitus (n = 19, 1.5%), and chronic obstructive pulmonary disease (n = 10, 0.8%) were the common co-morbidities. Haemoptysis was the most frequent presenting symptom, reported in up to 717 (57%) cases. Smoking (n = 69, 5.5%), recurrent lung infections (n = 41, 3%) and bronchorrhea (n = 33, 3%) were noted. This study confirms that CPA is common in Africa, with pulmonary tuberculosis being the most important risk factor. MDPI 2021-09-23 /pmc/articles/PMC8541146/ /pubmed/34682212 http://dx.doi.org/10.3390/jof7100790 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Olum, Ronald
Osaigbovo, Iriagbonse Iyabo
Baluku, Joseph Baruch
Stemler, Jannik
Kwizera, Richard
Bongomin, Felix
Mapping of Chronic Pulmonary Aspergillosis in Africa
title Mapping of Chronic Pulmonary Aspergillosis in Africa
title_full Mapping of Chronic Pulmonary Aspergillosis in Africa
title_fullStr Mapping of Chronic Pulmonary Aspergillosis in Africa
title_full_unstemmed Mapping of Chronic Pulmonary Aspergillosis in Africa
title_short Mapping of Chronic Pulmonary Aspergillosis in Africa
title_sort mapping of chronic pulmonary aspergillosis in africa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541146/
https://www.ncbi.nlm.nih.gov/pubmed/34682212
http://dx.doi.org/10.3390/jof7100790
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