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First Clinical Case of Equine Parvovirus-Hepatitis-Related Theiler’s Disease in Asia

Equine parvovirus-hepatitis (EqPV-H) is a newly identified etiologic agent of Theiler’s disease (TD). We present a case of EqPV-H-related fulminant hepatitis in a 14-year-old thoroughbred mare in Korea. The mare had acute hepatopathy and gastrointestinal symptoms, with abnormal liver-related blood p...

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Autores principales: Yoon, Jungho, Park, Taemook, Kim, Ahram, Park, Jongyoung, Park, Byung-Joo, Ahn, Hee-Seop, Go, Hyeon-Jeong, Kim, Dong-Hwi, Jung, Soontag, Seo, Yeeun, Lee, Joong-Bok, Park, Seung-Yong, Song, Chang-Seon, Lee, Sang-Won, Choi, In-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541225/
https://www.ncbi.nlm.nih.gov/pubmed/34696347
http://dx.doi.org/10.3390/v13101917
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author Yoon, Jungho
Park, Taemook
Kim, Ahram
Park, Jongyoung
Park, Byung-Joo
Ahn, Hee-Seop
Go, Hyeon-Jeong
Kim, Dong-Hwi
Jung, Soontag
Seo, Yeeun
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Choi, In-Soo
author_facet Yoon, Jungho
Park, Taemook
Kim, Ahram
Park, Jongyoung
Park, Byung-Joo
Ahn, Hee-Seop
Go, Hyeon-Jeong
Kim, Dong-Hwi
Jung, Soontag
Seo, Yeeun
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Choi, In-Soo
author_sort Yoon, Jungho
collection PubMed
description Equine parvovirus-hepatitis (EqPV-H) is a newly identified etiologic agent of Theiler’s disease (TD). We present a case of EqPV-H-related fulminant hepatitis in a 14-year-old thoroughbred mare in Korea. The mare had acute hepatopathy and gastrointestinal symptoms, with abnormal liver-related blood parameters. The horse was born in the USA and imported to Korea in 2017, with no history of administration of equine biological products after entry into Korea. The horse was diagnosed with EqPV-H-associated hepatitis after abdominal ultrasonography, laparotomy, and nested polymerase chain reaction (PCR) and in situ hybridization (ISH) assays. The serum, nasal swab, oral swab, and liver biopsy were positive for EqPV-H according to the PCR assay. Genetic analysis of the partial NS1 gene of EqPV-H showed a unique nucleotide substitution, distinct from that in previously deposited strains. EqPV-H DNA was found not only in hepatocytes but also in bile duct epithelium and Kupffer cells, particularly via ISH. To the best of our knowledge, this is the first case of EqPV-H-associated TD in Asia, providing the first clinical evidence for viral shedding from the mouth and nose, and identification of EqPV-H in the liver. This study contributes to a better understanding of the pathological features of EqPV-H-associated TD.
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spelling pubmed-85412252021-10-24 First Clinical Case of Equine Parvovirus-Hepatitis-Related Theiler’s Disease in Asia Yoon, Jungho Park, Taemook Kim, Ahram Park, Jongyoung Park, Byung-Joo Ahn, Hee-Seop Go, Hyeon-Jeong Kim, Dong-Hwi Jung, Soontag Seo, Yeeun Lee, Joong-Bok Park, Seung-Yong Song, Chang-Seon Lee, Sang-Won Choi, In-Soo Viruses Communication Equine parvovirus-hepatitis (EqPV-H) is a newly identified etiologic agent of Theiler’s disease (TD). We present a case of EqPV-H-related fulminant hepatitis in a 14-year-old thoroughbred mare in Korea. The mare had acute hepatopathy and gastrointestinal symptoms, with abnormal liver-related blood parameters. The horse was born in the USA and imported to Korea in 2017, with no history of administration of equine biological products after entry into Korea. The horse was diagnosed with EqPV-H-associated hepatitis after abdominal ultrasonography, laparotomy, and nested polymerase chain reaction (PCR) and in situ hybridization (ISH) assays. The serum, nasal swab, oral swab, and liver biopsy were positive for EqPV-H according to the PCR assay. Genetic analysis of the partial NS1 gene of EqPV-H showed a unique nucleotide substitution, distinct from that in previously deposited strains. EqPV-H DNA was found not only in hepatocytes but also in bile duct epithelium and Kupffer cells, particularly via ISH. To the best of our knowledge, this is the first case of EqPV-H-associated TD in Asia, providing the first clinical evidence for viral shedding from the mouth and nose, and identification of EqPV-H in the liver. This study contributes to a better understanding of the pathological features of EqPV-H-associated TD. MDPI 2021-09-24 /pmc/articles/PMC8541225/ /pubmed/34696347 http://dx.doi.org/10.3390/v13101917 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Yoon, Jungho
Park, Taemook
Kim, Ahram
Park, Jongyoung
Park, Byung-Joo
Ahn, Hee-Seop
Go, Hyeon-Jeong
Kim, Dong-Hwi
Jung, Soontag
Seo, Yeeun
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Choi, In-Soo
First Clinical Case of Equine Parvovirus-Hepatitis-Related Theiler’s Disease in Asia
title First Clinical Case of Equine Parvovirus-Hepatitis-Related Theiler’s Disease in Asia
title_full First Clinical Case of Equine Parvovirus-Hepatitis-Related Theiler’s Disease in Asia
title_fullStr First Clinical Case of Equine Parvovirus-Hepatitis-Related Theiler’s Disease in Asia
title_full_unstemmed First Clinical Case of Equine Parvovirus-Hepatitis-Related Theiler’s Disease in Asia
title_short First Clinical Case of Equine Parvovirus-Hepatitis-Related Theiler’s Disease in Asia
title_sort first clinical case of equine parvovirus-hepatitis-related theiler’s disease in asia
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541225/
https://www.ncbi.nlm.nih.gov/pubmed/34696347
http://dx.doi.org/10.3390/v13101917
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