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Exploring Implementation of Personal Breast Cancer Risk Assessments

Personal Breast Cancer (BC) Risk Assessments (PBCRA) have potential to stratify women into clinically-actionable BC risk categories. As this could involve population-wide genomic testing, women’s attitudes to PBCRA and views on acceptable implementation platforms must be considered to ensure optimal...

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Autores principales: Sierra, Maria A., Wheeler, Jack C. W., Devereux, Lisa, Trainer, Alison H., Keogh, Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541275/
https://www.ncbi.nlm.nih.gov/pubmed/34683136
http://dx.doi.org/10.3390/jpm11100992
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author Sierra, Maria A.
Wheeler, Jack C. W.
Devereux, Lisa
Trainer, Alison H.
Keogh, Louise
author_facet Sierra, Maria A.
Wheeler, Jack C. W.
Devereux, Lisa
Trainer, Alison H.
Keogh, Louise
author_sort Sierra, Maria A.
collection PubMed
description Personal Breast Cancer (BC) Risk Assessments (PBCRA) have potential to stratify women into clinically-actionable BC risk categories. As this could involve population-wide genomic testing, women’s attitudes to PBCRA and views on acceptable implementation platforms must be considered to ensure optimal population participation. We explored these issues with 31 women with different BC risk profiles through semi-structured focus group discussions or interviews. Inductive thematic coding of transcripts was performed. Subsequently, women listed factors that would impact on their decision to participate. Participants’ attitudes to PBCRA were positive. Identified themes included that PBCRA acceptance hinges on result actionability. Women value the ability to inform decision-making. Participants reported anxiety, stress, and genetic discrimination as potential barriers. The age at which PBCRA was offered, ease of access, and how results are returned held importance. Most women value the opportunity for PBCRA to inform increased surveillance, while highlighting hesitance to accept reduced surveillance as they find reassurance in regular screening. Women with BRCA pathogenic variants value the potential for PBCRA to identify a lower cancer risk and potentially inform delayed prophylactic surgery. This study highlights complexities in adopting advances in BC early detection, especially for current users who value existing processes as a social good.
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spelling pubmed-85412752021-10-24 Exploring Implementation of Personal Breast Cancer Risk Assessments Sierra, Maria A. Wheeler, Jack C. W. Devereux, Lisa Trainer, Alison H. Keogh, Louise J Pers Med Article Personal Breast Cancer (BC) Risk Assessments (PBCRA) have potential to stratify women into clinically-actionable BC risk categories. As this could involve population-wide genomic testing, women’s attitudes to PBCRA and views on acceptable implementation platforms must be considered to ensure optimal population participation. We explored these issues with 31 women with different BC risk profiles through semi-structured focus group discussions or interviews. Inductive thematic coding of transcripts was performed. Subsequently, women listed factors that would impact on their decision to participate. Participants’ attitudes to PBCRA were positive. Identified themes included that PBCRA acceptance hinges on result actionability. Women value the ability to inform decision-making. Participants reported anxiety, stress, and genetic discrimination as potential barriers. The age at which PBCRA was offered, ease of access, and how results are returned held importance. Most women value the opportunity for PBCRA to inform increased surveillance, while highlighting hesitance to accept reduced surveillance as they find reassurance in regular screening. Women with BRCA pathogenic variants value the potential for PBCRA to identify a lower cancer risk and potentially inform delayed prophylactic surgery. This study highlights complexities in adopting advances in BC early detection, especially for current users who value existing processes as a social good. MDPI 2021-09-30 /pmc/articles/PMC8541275/ /pubmed/34683136 http://dx.doi.org/10.3390/jpm11100992 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sierra, Maria A.
Wheeler, Jack C. W.
Devereux, Lisa
Trainer, Alison H.
Keogh, Louise
Exploring Implementation of Personal Breast Cancer Risk Assessments
title Exploring Implementation of Personal Breast Cancer Risk Assessments
title_full Exploring Implementation of Personal Breast Cancer Risk Assessments
title_fullStr Exploring Implementation of Personal Breast Cancer Risk Assessments
title_full_unstemmed Exploring Implementation of Personal Breast Cancer Risk Assessments
title_short Exploring Implementation of Personal Breast Cancer Risk Assessments
title_sort exploring implementation of personal breast cancer risk assessments
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541275/
https://www.ncbi.nlm.nih.gov/pubmed/34683136
http://dx.doi.org/10.3390/jpm11100992
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