A Novel Phenylpyrrolidine Derivative: Synthesis and Effect on Cognitive Functions in Rats with Experimental Ishemic Stroke

We performed an in silico, in vitro, and in vivo assessment of a potassium 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl) acetamido]ethanesulfonate (compound 1) as a potential prodrug for cognitive function improvement in ischemic brain injury. Using in silico methods, we predicted the pharmacological efficac...

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Detalles Bibliográficos
Autores principales: Borozdenko, Denis A., Ezdoglian, Aiarpi A., Shmigol, Tatiana A., Gonchar, Darya I., Lyakhmun, Dmitri N., Tarasenko, Dmitri V., Golubev, Yaroslav V., Cherkashova, Elvira A., Namestnikova, Daria D., Gubskiy, Ilya L., Lagunin, Alexey A., Gubsky, Leonid V., Chekhonin, Vladimir P., Borisevich, Sophia S., Gureev, Maxim A., Shagina, Anastasia D., Kiseleva, Nina M., Negrebetsky, Vadim V., Baukov, Yuri I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541353/
https://www.ncbi.nlm.nih.gov/pubmed/34684709
http://dx.doi.org/10.3390/molecules26206124

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