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Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis

Background: Leptin is a satiety hormone mainly produced by white adipose tissue. Decreasing levels have been described following acute stress. Objective: To conduct a systematic review and meta-analysis to determine if leptin can be a biomarker of stress, with levels decreasing following acute stres...

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Autores principales: Bouillon-Minois, Jean-Baptiste, Trousselard, Marion, Thivel, David, Benson, Amanda C., Schmidt, Jeannot, Moustafa, Farès, Bouvier, Damien, Dutheil, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541372/
https://www.ncbi.nlm.nih.gov/pubmed/34684349
http://dx.doi.org/10.3390/nu13103350
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author Bouillon-Minois, Jean-Baptiste
Trousselard, Marion
Thivel, David
Benson, Amanda C.
Schmidt, Jeannot
Moustafa, Farès
Bouvier, Damien
Dutheil, Frédéric
author_facet Bouillon-Minois, Jean-Baptiste
Trousselard, Marion
Thivel, David
Benson, Amanda C.
Schmidt, Jeannot
Moustafa, Farès
Bouvier, Damien
Dutheil, Frédéric
author_sort Bouillon-Minois, Jean-Baptiste
collection PubMed
description Background: Leptin is a satiety hormone mainly produced by white adipose tissue. Decreasing levels have been described following acute stress. Objective: To conduct a systematic review and meta-analysis to determine if leptin can be a biomarker of stress, with levels decreasing following acute stress. Methods: PubMed, Cochrane Library, Embase, and ScienceDirect were searched to obtain all articles studying leptin levels after acute stress on 15 February 2021. We included articles reporting leptin levels before and after acute stress (physical or psychological) and conducted random effects meta-analysis (DerSimonian and Laird approach). We conducted Meta-regressions and sensitivity analyses after exclusion of groups outside the metafunnel. Results: We included seven articles—four cohort and three case-control studies—(28 groups) from 27,983 putative articles. Leptin levels decreased after the stress intervention (effect size = −0.34, 95%CI −0.66 to −0.02) compared with baseline levels, with a greater decrease after 60 min compared to mean decrease (−0.45, −0.89 to −0.01) and in normal weight compared to overweight individuals (−0.79, −1.38 to −0.21). There was no difference in the overweight population. Sensitivity analyses demonstrated similar results. Levels of leptin after stress decreased with sex ratio—i.e., number of men/women—(−0.924, 95%CI −1.58 to −0.27) and increased with the baseline levels of leptin (0.039, 0.01 to 0.07). Conclusions: Leptin is a biomarker of stress, with a decrease following acute stress. Normal-weight individuals and women also have a higher variation of leptin levels after stress, suggesting that leptin may have implications in obesity development in response to stress in a sex-dependent manner.
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spelling pubmed-85413722021-10-24 Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis Bouillon-Minois, Jean-Baptiste Trousselard, Marion Thivel, David Benson, Amanda C. Schmidt, Jeannot Moustafa, Farès Bouvier, Damien Dutheil, Frédéric Nutrients Review Background: Leptin is a satiety hormone mainly produced by white adipose tissue. Decreasing levels have been described following acute stress. Objective: To conduct a systematic review and meta-analysis to determine if leptin can be a biomarker of stress, with levels decreasing following acute stress. Methods: PubMed, Cochrane Library, Embase, and ScienceDirect were searched to obtain all articles studying leptin levels after acute stress on 15 February 2021. We included articles reporting leptin levels before and after acute stress (physical or psychological) and conducted random effects meta-analysis (DerSimonian and Laird approach). We conducted Meta-regressions and sensitivity analyses after exclusion of groups outside the metafunnel. Results: We included seven articles—four cohort and three case-control studies—(28 groups) from 27,983 putative articles. Leptin levels decreased after the stress intervention (effect size = −0.34, 95%CI −0.66 to −0.02) compared with baseline levels, with a greater decrease after 60 min compared to mean decrease (−0.45, −0.89 to −0.01) and in normal weight compared to overweight individuals (−0.79, −1.38 to −0.21). There was no difference in the overweight population. Sensitivity analyses demonstrated similar results. Levels of leptin after stress decreased with sex ratio—i.e., number of men/women—(−0.924, 95%CI −1.58 to −0.27) and increased with the baseline levels of leptin (0.039, 0.01 to 0.07). Conclusions: Leptin is a biomarker of stress, with a decrease following acute stress. Normal-weight individuals and women also have a higher variation of leptin levels after stress, suggesting that leptin may have implications in obesity development in response to stress in a sex-dependent manner. MDPI 2021-09-24 /pmc/articles/PMC8541372/ /pubmed/34684349 http://dx.doi.org/10.3390/nu13103350 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bouillon-Minois, Jean-Baptiste
Trousselard, Marion
Thivel, David
Benson, Amanda C.
Schmidt, Jeannot
Moustafa, Farès
Bouvier, Damien
Dutheil, Frédéric
Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis
title Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis
title_full Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis
title_fullStr Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis
title_full_unstemmed Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis
title_short Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis
title_sort leptin as a biomarker of stress: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541372/
https://www.ncbi.nlm.nih.gov/pubmed/34684349
http://dx.doi.org/10.3390/nu13103350
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