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Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery

Both ionic and enzymatic crosslink are efficient strategies for constructing network materials of high biocompatibility. Here chitosan was modified firstly and then crosslinked by these two methods for complementary advantages. The preparation methods and ionic crosslinkers can regulate the size and...

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Autores principales: Tao, Qian, Zhong, Julong, Wang, Rui, Huang, Yuzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541401/
https://www.ncbi.nlm.nih.gov/pubmed/34685323
http://dx.doi.org/10.3390/polym13203565
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author Tao, Qian
Zhong, Julong
Wang, Rui
Huang, Yuzhu
author_facet Tao, Qian
Zhong, Julong
Wang, Rui
Huang, Yuzhu
author_sort Tao, Qian
collection PubMed
description Both ionic and enzymatic crosslink are efficient strategies for constructing network materials of high biocompatibility. Here chitosan was modified firstly and then crosslinked by these two methods for complementary advantages. The preparation methods and ionic crosslinkers can regulate the size and uniformity of the multiple-crosslinked nanogels. The multiple-crosslinked nanogels with the smallest size and the best uniformity was selected for the drug delivery. The drug-loading content and encapsulation efficiency were up to 35.01 and 66.82%, respectively. Their release behaviours are correlated with the pH value and the drug dosage. In general, the lower pH value and the lower drug dosage promoted the drug release. With the assistance of several kinetic models, it is found that drug diffusion plays a preponderant role in drug release, while polymer relaxation has a subtle effect. The multiple-crosslink resulting from ionic compounds and enzymes may provide a new perspective on developing novel biocompatible materials.
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spelling pubmed-85414012021-10-24 Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery Tao, Qian Zhong, Julong Wang, Rui Huang, Yuzhu Polymers (Basel) Article Both ionic and enzymatic crosslink are efficient strategies for constructing network materials of high biocompatibility. Here chitosan was modified firstly and then crosslinked by these two methods for complementary advantages. The preparation methods and ionic crosslinkers can regulate the size and uniformity of the multiple-crosslinked nanogels. The multiple-crosslinked nanogels with the smallest size and the best uniformity was selected for the drug delivery. The drug-loading content and encapsulation efficiency were up to 35.01 and 66.82%, respectively. Their release behaviours are correlated with the pH value and the drug dosage. In general, the lower pH value and the lower drug dosage promoted the drug release. With the assistance of several kinetic models, it is found that drug diffusion plays a preponderant role in drug release, while polymer relaxation has a subtle effect. The multiple-crosslink resulting from ionic compounds and enzymes may provide a new perspective on developing novel biocompatible materials. MDPI 2021-10-15 /pmc/articles/PMC8541401/ /pubmed/34685323 http://dx.doi.org/10.3390/polym13203565 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tao, Qian
Zhong, Julong
Wang, Rui
Huang, Yuzhu
Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery
title Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery
title_full Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery
title_fullStr Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery
title_full_unstemmed Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery
title_short Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery
title_sort ionic and enzymatic multiple-crosslinked nanogels for drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541401/
https://www.ncbi.nlm.nih.gov/pubmed/34685323
http://dx.doi.org/10.3390/polym13203565
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