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Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery
Both ionic and enzymatic crosslink are efficient strategies for constructing network materials of high biocompatibility. Here chitosan was modified firstly and then crosslinked by these two methods for complementary advantages. The preparation methods and ionic crosslinkers can regulate the size and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541401/ https://www.ncbi.nlm.nih.gov/pubmed/34685323 http://dx.doi.org/10.3390/polym13203565 |
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author | Tao, Qian Zhong, Julong Wang, Rui Huang, Yuzhu |
author_facet | Tao, Qian Zhong, Julong Wang, Rui Huang, Yuzhu |
author_sort | Tao, Qian |
collection | PubMed |
description | Both ionic and enzymatic crosslink are efficient strategies for constructing network materials of high biocompatibility. Here chitosan was modified firstly and then crosslinked by these two methods for complementary advantages. The preparation methods and ionic crosslinkers can regulate the size and uniformity of the multiple-crosslinked nanogels. The multiple-crosslinked nanogels with the smallest size and the best uniformity was selected for the drug delivery. The drug-loading content and encapsulation efficiency were up to 35.01 and 66.82%, respectively. Their release behaviours are correlated with the pH value and the drug dosage. In general, the lower pH value and the lower drug dosage promoted the drug release. With the assistance of several kinetic models, it is found that drug diffusion plays a preponderant role in drug release, while polymer relaxation has a subtle effect. The multiple-crosslink resulting from ionic compounds and enzymes may provide a new perspective on developing novel biocompatible materials. |
format | Online Article Text |
id | pubmed-8541401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85414012021-10-24 Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery Tao, Qian Zhong, Julong Wang, Rui Huang, Yuzhu Polymers (Basel) Article Both ionic and enzymatic crosslink are efficient strategies for constructing network materials of high biocompatibility. Here chitosan was modified firstly and then crosslinked by these two methods for complementary advantages. The preparation methods and ionic crosslinkers can regulate the size and uniformity of the multiple-crosslinked nanogels. The multiple-crosslinked nanogels with the smallest size and the best uniformity was selected for the drug delivery. The drug-loading content and encapsulation efficiency were up to 35.01 and 66.82%, respectively. Their release behaviours are correlated with the pH value and the drug dosage. In general, the lower pH value and the lower drug dosage promoted the drug release. With the assistance of several kinetic models, it is found that drug diffusion plays a preponderant role in drug release, while polymer relaxation has a subtle effect. The multiple-crosslink resulting from ionic compounds and enzymes may provide a new perspective on developing novel biocompatible materials. MDPI 2021-10-15 /pmc/articles/PMC8541401/ /pubmed/34685323 http://dx.doi.org/10.3390/polym13203565 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tao, Qian Zhong, Julong Wang, Rui Huang, Yuzhu Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery |
title | Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery |
title_full | Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery |
title_fullStr | Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery |
title_full_unstemmed | Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery |
title_short | Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery |
title_sort | ionic and enzymatic multiple-crosslinked nanogels for drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541401/ https://www.ncbi.nlm.nih.gov/pubmed/34685323 http://dx.doi.org/10.3390/polym13203565 |
work_keys_str_mv | AT taoqian ionicandenzymaticmultiplecrosslinkednanogelsfordrugdelivery AT zhongjulong ionicandenzymaticmultiplecrosslinkednanogelsfordrugdelivery AT wangrui ionicandenzymaticmultiplecrosslinkednanogelsfordrugdelivery AT huangyuzhu ionicandenzymaticmultiplecrosslinkednanogelsfordrugdelivery |