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Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)

Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by th...

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Autores principales: da Silva, Éden Bruno Sousa, Barata, Lauro Euclides Soares, Arévalo, Michelly Rios, Vieira, Leda Quercia, Castro, Waldionê, Ruiz, Ana Lúcia Tasca Gois, Torre, Adriana Della, Castro, Kelly Christina Ferreira, Sartoratto, Adilson, Baratto, Leopoldo C., de Santana, Maxwell Barbosa, Minervino, Antonio Humberto Hamad, Moraes, Waldiney Pires
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541438/
https://www.ncbi.nlm.nih.gov/pubmed/34685893
http://dx.doi.org/10.3390/plants10102084
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author da Silva, Éden Bruno Sousa
Barata, Lauro Euclides Soares
Arévalo, Michelly Rios
Vieira, Leda Quercia
Castro, Waldionê
Ruiz, Ana Lúcia Tasca Gois
Torre, Adriana Della
Castro, Kelly Christina Ferreira
Sartoratto, Adilson
Baratto, Leopoldo C.
de Santana, Maxwell Barbosa
Minervino, Antonio Humberto Hamad
Moraes, Waldiney Pires
author_facet da Silva, Éden Bruno Sousa
Barata, Lauro Euclides Soares
Arévalo, Michelly Rios
Vieira, Leda Quercia
Castro, Waldionê
Ruiz, Ana Lúcia Tasca Gois
Torre, Adriana Della
Castro, Kelly Christina Ferreira
Sartoratto, Adilson
Baratto, Leopoldo C.
de Santana, Maxwell Barbosa
Minervino, Antonio Humberto Hamad
Moraes, Waldiney Pires
author_sort da Silva, Éden Bruno Sousa
collection PubMed
description Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by the extraction of essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil of C. articulatus L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of sesquiterpenes and particularly sequiterpenic ketones as main constituents. The results showed that the treatment with ethanolic extract of C. articulatus L. reduced the activity of the enzyme arginase and proliferation of cancer cells (p < 0.0001). The extract also showed no cytotoxicity in macrophages in concentrations between 12.5; 25 and 50 mg/mL (p < 0.0001). The results indicated that the extract of C. articulatus L. exerts antiproliferative activity (p < 0.0001) with low toxicity on healthy cells in experimental models in vitro.
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spelling pubmed-85414382021-10-24 Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae) da Silva, Éden Bruno Sousa Barata, Lauro Euclides Soares Arévalo, Michelly Rios Vieira, Leda Quercia Castro, Waldionê Ruiz, Ana Lúcia Tasca Gois Torre, Adriana Della Castro, Kelly Christina Ferreira Sartoratto, Adilson Baratto, Leopoldo C. de Santana, Maxwell Barbosa Minervino, Antonio Humberto Hamad Moraes, Waldiney Pires Plants (Basel) Brief Report Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by the extraction of essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil of C. articulatus L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of sesquiterpenes and particularly sequiterpenic ketones as main constituents. The results showed that the treatment with ethanolic extract of C. articulatus L. reduced the activity of the enzyme arginase and proliferation of cancer cells (p < 0.0001). The extract also showed no cytotoxicity in macrophages in concentrations between 12.5; 25 and 50 mg/mL (p < 0.0001). The results indicated that the extract of C. articulatus L. exerts antiproliferative activity (p < 0.0001) with low toxicity on healthy cells in experimental models in vitro. MDPI 2021-10-01 /pmc/articles/PMC8541438/ /pubmed/34685893 http://dx.doi.org/10.3390/plants10102084 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
da Silva, Éden Bruno Sousa
Barata, Lauro Euclides Soares
Arévalo, Michelly Rios
Vieira, Leda Quercia
Castro, Waldionê
Ruiz, Ana Lúcia Tasca Gois
Torre, Adriana Della
Castro, Kelly Christina Ferreira
Sartoratto, Adilson
Baratto, Leopoldo C.
de Santana, Maxwell Barbosa
Minervino, Antonio Humberto Hamad
Moraes, Waldiney Pires
Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)
title Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)
title_full Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)
title_fullStr Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)
title_full_unstemmed Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)
title_short Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)
title_sort chemical composition and antiproliferative activity of the ethanolic extract of cyperus articulatus l. (cyperaceae)
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541438/
https://www.ncbi.nlm.nih.gov/pubmed/34685893
http://dx.doi.org/10.3390/plants10102084
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