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New Advances in Tissue Metabolomics: A Review

Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical medicine while also providing better understanding of the underlying mechanisms of chronic diseases. Clinical metabolomic studies largely rely on human biofluids (e.g., plasma, urine) as a more convenient specim...

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Detalles Bibliográficos
Autores principales: Saoi, Michelle, Britz-McKibbin, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541552/
https://www.ncbi.nlm.nih.gov/pubmed/34677387
http://dx.doi.org/10.3390/metabo11100672
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author Saoi, Michelle
Britz-McKibbin, Philip
author_facet Saoi, Michelle
Britz-McKibbin, Philip
author_sort Saoi, Michelle
collection PubMed
description Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical medicine while also providing better understanding of the underlying mechanisms of chronic diseases. Clinical metabolomic studies largely rely on human biofluids (e.g., plasma, urine) as a more convenient specimen type for investigation. However, biofluids are non-organ specific reflecting complex biochemical processes throughout the body, which may complicate biochemical interpretations. For these reasons, tissue metabolomic studies enable deeper insights into aberrant metabolism occurring at the direct site of disease pathogenesis. This review highlights new advances in metabolomics for ex vivo analysis, as well as in situ imaging of tissue specimens, including diverse tissue types from animal models and human participants. Moreover, we discuss key pre-analytical and post-analytical challenges in tissue metabolomics for robust biomarker discovery with a focus on new methodological advances introduced over the past six years, including innovative clinical applications for improved screening, diagnostic testing, and therapeutic interventions for cancer.
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spelling pubmed-85415522021-10-24 New Advances in Tissue Metabolomics: A Review Saoi, Michelle Britz-McKibbin, Philip Metabolites Review Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical medicine while also providing better understanding of the underlying mechanisms of chronic diseases. Clinical metabolomic studies largely rely on human biofluids (e.g., plasma, urine) as a more convenient specimen type for investigation. However, biofluids are non-organ specific reflecting complex biochemical processes throughout the body, which may complicate biochemical interpretations. For these reasons, tissue metabolomic studies enable deeper insights into aberrant metabolism occurring at the direct site of disease pathogenesis. This review highlights new advances in metabolomics for ex vivo analysis, as well as in situ imaging of tissue specimens, including diverse tissue types from animal models and human participants. Moreover, we discuss key pre-analytical and post-analytical challenges in tissue metabolomics for robust biomarker discovery with a focus on new methodological advances introduced over the past six years, including innovative clinical applications for improved screening, diagnostic testing, and therapeutic interventions for cancer. MDPI 2021-09-30 /pmc/articles/PMC8541552/ /pubmed/34677387 http://dx.doi.org/10.3390/metabo11100672 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saoi, Michelle
Britz-McKibbin, Philip
New Advances in Tissue Metabolomics: A Review
title New Advances in Tissue Metabolomics: A Review
title_full New Advances in Tissue Metabolomics: A Review
title_fullStr New Advances in Tissue Metabolomics: A Review
title_full_unstemmed New Advances in Tissue Metabolomics: A Review
title_short New Advances in Tissue Metabolomics: A Review
title_sort new advances in tissue metabolomics: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541552/
https://www.ncbi.nlm.nih.gov/pubmed/34677387
http://dx.doi.org/10.3390/metabo11100672
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