Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System

Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which...

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Detalles Bibliográficos
Autores principales: Guffey, Alexandra A., Loll, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541618/
https://www.ncbi.nlm.nih.gov/pubmed/34683347
http://dx.doi.org/10.3390/microorganisms9102026
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author Guffey, Alexandra A.
Loll, Patrick J.
author_facet Guffey, Alexandra A.
Loll, Patrick J.
author_sort Guffey, Alexandra A.
collection PubMed
description Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which regulates the expression of vancomycin resistance in VRE. VanS is a sensor histidine kinase that detects vancomycin and in turn activates VanR; VanR is a response regulator that, when activated, directs expression of vancomycin-resistance genes. This review of VanRS examines how the expression of vancomycin resistance is regulated, and provides an update on one of the field’s most pressing questions: How does VanS sense vancomycin?
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spelling pubmed-85416182021-10-24 Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System Guffey, Alexandra A. Loll, Patrick J. Microorganisms Review Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which regulates the expression of vancomycin resistance in VRE. VanS is a sensor histidine kinase that detects vancomycin and in turn activates VanR; VanR is a response regulator that, when activated, directs expression of vancomycin-resistance genes. This review of VanRS examines how the expression of vancomycin resistance is regulated, and provides an update on one of the field’s most pressing questions: How does VanS sense vancomycin? MDPI 2021-09-25 /pmc/articles/PMC8541618/ /pubmed/34683347 http://dx.doi.org/10.3390/microorganisms9102026 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guffey, Alexandra A.
Loll, Patrick J.
Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
title Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
title_full Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
title_fullStr Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
title_full_unstemmed Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
title_short Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
title_sort regulation of resistance in vancomycin-resistant enterococci: the vanrs two-component system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541618/
https://www.ncbi.nlm.nih.gov/pubmed/34683347
http://dx.doi.org/10.3390/microorganisms9102026
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