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The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women

Background: Microvascular angina is a common clinical entity, with about a three-fold higher frequency in women. The pathogenesis of microvascular angina has not been much studied, but inflammation and endothelial dysfunction have been incriminated as the main mechanisms of this disease. Methoss: Ou...

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Autores principales: Gurzău, Diana, Sitar-Tăut, Adela, Caloian, Bogdan, Guşetu, Gabriel, Comşa, Horaţiu, Frîngu, Florina, Zdrenghea, Dumitru, Pop, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541623/
https://www.ncbi.nlm.nih.gov/pubmed/34683106
http://dx.doi.org/10.3390/jpm11100965
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author Gurzău, Diana
Sitar-Tăut, Adela
Caloian, Bogdan
Guşetu, Gabriel
Comşa, Horaţiu
Frîngu, Florina
Zdrenghea, Dumitru
Pop, Dana
author_facet Gurzău, Diana
Sitar-Tăut, Adela
Caloian, Bogdan
Guşetu, Gabriel
Comşa, Horaţiu
Frîngu, Florina
Zdrenghea, Dumitru
Pop, Dana
author_sort Gurzău, Diana
collection PubMed
description Background: Microvascular angina is a common clinical entity, with about a three-fold higher frequency in women. The pathogenesis of microvascular angina has not been much studied, but inflammation and endothelial dysfunction have been incriminated as the main mechanisms of this disease. Methoss: Our purpose was to analyze whether certain inflammatory markers, i.e., interleukin 6 (IL-6) and endothelin 1 (ET-1), can play a role in the diagnosis of microvascular angina in women. Results: Ninety women with ischemic heart disease were divided into two groups, based on their affliction with either microvascular or macrovascular disease. In general, the levels of IL6 and ET1 were similar between the two groups. Analyzing these marker levels according to the number of coronary lesions, we obtained an increased IL6 value that was similar for patients with microvascular angina, one-vessel, and two-vessel coronary disease, but significantly lower than in women with three-vessel coronary lesions. Also, in microvascular angina, IL6 level was correlated with the NYHA IV functional class. Unexpectedly, the level of ET1 was correlated with left ventricular systolic dysfunction. Conclusions: In women with an increased suspicion of microvascular angina, in whom microvascular dysfunction cannot be tested invasively, IL-6 level, unlike the ET-1 level, might be considered a diagnostic marker of this disease.
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spelling pubmed-85416232021-10-24 The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women Gurzău, Diana Sitar-Tăut, Adela Caloian, Bogdan Guşetu, Gabriel Comşa, Horaţiu Frîngu, Florina Zdrenghea, Dumitru Pop, Dana J Pers Med Article Background: Microvascular angina is a common clinical entity, with about a three-fold higher frequency in women. The pathogenesis of microvascular angina has not been much studied, but inflammation and endothelial dysfunction have been incriminated as the main mechanisms of this disease. Methoss: Our purpose was to analyze whether certain inflammatory markers, i.e., interleukin 6 (IL-6) and endothelin 1 (ET-1), can play a role in the diagnosis of microvascular angina in women. Results: Ninety women with ischemic heart disease were divided into two groups, based on their affliction with either microvascular or macrovascular disease. In general, the levels of IL6 and ET1 were similar between the two groups. Analyzing these marker levels according to the number of coronary lesions, we obtained an increased IL6 value that was similar for patients with microvascular angina, one-vessel, and two-vessel coronary disease, but significantly lower than in women with three-vessel coronary lesions. Also, in microvascular angina, IL6 level was correlated with the NYHA IV functional class. Unexpectedly, the level of ET1 was correlated with left ventricular systolic dysfunction. Conclusions: In women with an increased suspicion of microvascular angina, in whom microvascular dysfunction cannot be tested invasively, IL-6 level, unlike the ET-1 level, might be considered a diagnostic marker of this disease. MDPI 2021-09-27 /pmc/articles/PMC8541623/ /pubmed/34683106 http://dx.doi.org/10.3390/jpm11100965 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gurzău, Diana
Sitar-Tăut, Adela
Caloian, Bogdan
Guşetu, Gabriel
Comşa, Horaţiu
Frîngu, Florina
Zdrenghea, Dumitru
Pop, Dana
The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women
title The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women
title_full The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women
title_fullStr The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women
title_full_unstemmed The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women
title_short The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women
title_sort role of il-6 and et-1 in the diagnosis of coronary microvascular disease in women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541623/
https://www.ncbi.nlm.nih.gov/pubmed/34683106
http://dx.doi.org/10.3390/jpm11100965
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