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Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives

The increasing incidence of drug- resistant pathogens raises an urgent need to identify and isolate new bioactive compounds from medicinal plants using standardized modern analytical procedures. Medicinal plant-derived compounds could provide novel straightforward approaches against pathogenic bacte...

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Autores principales: Vaou, Natalia, Stavropoulou, Elisavet, Voidarou, Chrysa, Tsigalou, Christina, Bezirtzoglou, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541629/
https://www.ncbi.nlm.nih.gov/pubmed/34683362
http://dx.doi.org/10.3390/microorganisms9102041
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author Vaou, Natalia
Stavropoulou, Elisavet
Voidarou, Chrysa
Tsigalou, Christina
Bezirtzoglou, Eugenia
author_facet Vaou, Natalia
Stavropoulou, Elisavet
Voidarou, Chrysa
Tsigalou, Christina
Bezirtzoglou, Eugenia
author_sort Vaou, Natalia
collection PubMed
description The increasing incidence of drug- resistant pathogens raises an urgent need to identify and isolate new bioactive compounds from medicinal plants using standardized modern analytical procedures. Medicinal plant-derived compounds could provide novel straightforward approaches against pathogenic bacteria. This review explores the antimicrobial activity of plant-derived components, their possible mechanisms of action, as well as their chemical potential. The focus is put on the current challenges and future perspectives surrounding medicinal plants antimicrobial activity. There are some inherent challenges regarding medicinal plant extracts and their antimicrobial efficacy. Appropriate and optimized extraction methodology plant species dependent leads to upgraded and selective extracted compounds. Antimicrobial susceptibility tests for the determination of the antimicrobial activity of plant extracts may show variations in obtained results. Moreover, there are several difficulties and problems that need to be overcome for the development of new antimicrobials from plant extracts, while efforts have been made to enhance the antimicrobial activity of chemical compounds. Research on the mechanisms of action, interplay with other substances, and the pharmacokinetic and/or pharmacodynamic profile of the medicinal plant extracts should be given high priority to characterize them as potential antimicrobial agents.
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spelling pubmed-85416292021-10-24 Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives Vaou, Natalia Stavropoulou, Elisavet Voidarou, Chrysa Tsigalou, Christina Bezirtzoglou, Eugenia Microorganisms Review The increasing incidence of drug- resistant pathogens raises an urgent need to identify and isolate new bioactive compounds from medicinal plants using standardized modern analytical procedures. Medicinal plant-derived compounds could provide novel straightforward approaches against pathogenic bacteria. This review explores the antimicrobial activity of plant-derived components, their possible mechanisms of action, as well as their chemical potential. The focus is put on the current challenges and future perspectives surrounding medicinal plants antimicrobial activity. There are some inherent challenges regarding medicinal plant extracts and their antimicrobial efficacy. Appropriate and optimized extraction methodology plant species dependent leads to upgraded and selective extracted compounds. Antimicrobial susceptibility tests for the determination of the antimicrobial activity of plant extracts may show variations in obtained results. Moreover, there are several difficulties and problems that need to be overcome for the development of new antimicrobials from plant extracts, while efforts have been made to enhance the antimicrobial activity of chemical compounds. Research on the mechanisms of action, interplay with other substances, and the pharmacokinetic and/or pharmacodynamic profile of the medicinal plant extracts should be given high priority to characterize them as potential antimicrobial agents. MDPI 2021-09-27 /pmc/articles/PMC8541629/ /pubmed/34683362 http://dx.doi.org/10.3390/microorganisms9102041 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vaou, Natalia
Stavropoulou, Elisavet
Voidarou, Chrysa
Tsigalou, Christina
Bezirtzoglou, Eugenia
Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives
title Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives
title_full Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives
title_fullStr Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives
title_full_unstemmed Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives
title_short Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives
title_sort towards advances in medicinal plant antimicrobial activity: a review study on challenges and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541629/
https://www.ncbi.nlm.nih.gov/pubmed/34683362
http://dx.doi.org/10.3390/microorganisms9102041
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