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Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii

Acinetobacter baumannii is an opportunistic pathogen which is undoubtedly known for a high rate of morbidity and mortality in hospital-acquired infections. A. baumannii causes life-threatening infections, including; ventilator-associated pneumonia (VAP), meningitis, bacteremia, and wound and urinary...

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Autores principales: Kumar, Sunil, Anwer, Razique, Azzi, Arezki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541637/
https://www.ncbi.nlm.nih.gov/pubmed/34683425
http://dx.doi.org/10.3390/microorganisms9102104
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author Kumar, Sunil
Anwer, Razique
Azzi, Arezki
author_facet Kumar, Sunil
Anwer, Razique
Azzi, Arezki
author_sort Kumar, Sunil
collection PubMed
description Acinetobacter baumannii is an opportunistic pathogen which is undoubtedly known for a high rate of morbidity and mortality in hospital-acquired infections. A. baumannii causes life-threatening infections, including; ventilator-associated pneumonia (VAP), meningitis, bacteremia, and wound and urinary tract infections (UTI). In 2017, the World Health Organization listed A. baumannii as a priority-1 pathogen. The prevalence of A. baumannii infections and outbreaks emphasizes the direct need for the use of effective therapeutic agents for treating such infections. Available antimicrobials, such as; carbapenems, tigecycline, and colistins have insufficient effectiveness due to the appearance of multidrug-resistant strains, accentuating the need for alternative and novel therapeutic remedies. To understand and overcome this menace, the knowledge of recent discoveries on the virulence factors of A. baumannii is needed. Herein, we summarized the role of various virulence factors, including; outer membrane proteins, efflux pumps, biofilm, penicillin-binding proteins, and siderophores/iron acquisition systems. We reviewed the recent scientific literature on different A. baumannii virulence factors and the effective antimicrobial agents for the treatment and management of bacterial infections.
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spelling pubmed-85416372021-10-24 Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii Kumar, Sunil Anwer, Razique Azzi, Arezki Microorganisms Review Acinetobacter baumannii is an opportunistic pathogen which is undoubtedly known for a high rate of morbidity and mortality in hospital-acquired infections. A. baumannii causes life-threatening infections, including; ventilator-associated pneumonia (VAP), meningitis, bacteremia, and wound and urinary tract infections (UTI). In 2017, the World Health Organization listed A. baumannii as a priority-1 pathogen. The prevalence of A. baumannii infections and outbreaks emphasizes the direct need for the use of effective therapeutic agents for treating such infections. Available antimicrobials, such as; carbapenems, tigecycline, and colistins have insufficient effectiveness due to the appearance of multidrug-resistant strains, accentuating the need for alternative and novel therapeutic remedies. To understand and overcome this menace, the knowledge of recent discoveries on the virulence factors of A. baumannii is needed. Herein, we summarized the role of various virulence factors, including; outer membrane proteins, efflux pumps, biofilm, penicillin-binding proteins, and siderophores/iron acquisition systems. We reviewed the recent scientific literature on different A. baumannii virulence factors and the effective antimicrobial agents for the treatment and management of bacterial infections. MDPI 2021-10-06 /pmc/articles/PMC8541637/ /pubmed/34683425 http://dx.doi.org/10.3390/microorganisms9102104 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kumar, Sunil
Anwer, Razique
Azzi, Arezki
Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii
title Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii
title_full Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii
title_fullStr Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii
title_full_unstemmed Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii
title_short Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii
title_sort virulence potential and treatment options of multidrug-resistant (mdr) acinetobacter baumannii
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541637/
https://www.ncbi.nlm.nih.gov/pubmed/34683425
http://dx.doi.org/10.3390/microorganisms9102104
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