Cargando…
The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2
Gastric cancer (GC) is the most common gastrointestinal cancer and the main cause of tumor-related death. Exploring markers for early diagnosis and new therapeutic targets is always on the way. In the last 10 years, long noncoding RNAs (lncRNAs) have been widely proved to be involved in the progress...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541877/ https://www.ncbi.nlm.nih.gov/pubmed/34697541 http://dx.doi.org/10.1155/2021/1173869 |
_version_ | 1784589336210046976 |
---|---|
author | Wang, Jinchun Wu, Jie Wang, Lei Min, Xuewen Chen, Zhujing |
author_facet | Wang, Jinchun Wu, Jie Wang, Lei Min, Xuewen Chen, Zhujing |
author_sort | Wang, Jinchun |
collection | PubMed |
description | Gastric cancer (GC) is the most common gastrointestinal cancer and the main cause of tumor-related death. Exploring markers for early diagnosis and new therapeutic targets is always on the way. In the last 10 years, long noncoding RNAs (lncRNAs) have been widely proved to be involved in the progress of many tumors and are regarded as potential targets for tumor therapy. We found that LINC00152, a newly identified lncRNA, was significantly upregulated in GC tissues and affected clinicopathological characteristics in GC patients. Furthermore, we observed that LINC00152 knockdown can significantly reduce cell proliferation and promote apoptosis in human gastric cancer cells. Further bioinformatic analysis indicated that LINC00152 competitively bound with miR-138 and regulated the expression of miR-138. Moreover, SIRT2 was further proved to be a downstream target of miR-138. Overall, this study elucidates the molecular mechanism of LINC00152 underlying the malignant phenotype of GC cells by mediating miR-138/SIRT2 axis, which provides a new understanding of the role and molecular mechanism of lncRNA in GC and also provides a new way for the treatment of gastric cancer. |
format | Online Article Text |
id | pubmed-8541877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-85418772021-10-24 The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2 Wang, Jinchun Wu, Jie Wang, Lei Min, Xuewen Chen, Zhujing J Oncol Research Article Gastric cancer (GC) is the most common gastrointestinal cancer and the main cause of tumor-related death. Exploring markers for early diagnosis and new therapeutic targets is always on the way. In the last 10 years, long noncoding RNAs (lncRNAs) have been widely proved to be involved in the progress of many tumors and are regarded as potential targets for tumor therapy. We found that LINC00152, a newly identified lncRNA, was significantly upregulated in GC tissues and affected clinicopathological characteristics in GC patients. Furthermore, we observed that LINC00152 knockdown can significantly reduce cell proliferation and promote apoptosis in human gastric cancer cells. Further bioinformatic analysis indicated that LINC00152 competitively bound with miR-138 and regulated the expression of miR-138. Moreover, SIRT2 was further proved to be a downstream target of miR-138. Overall, this study elucidates the molecular mechanism of LINC00152 underlying the malignant phenotype of GC cells by mediating miR-138/SIRT2 axis, which provides a new understanding of the role and molecular mechanism of lncRNA in GC and also provides a new way for the treatment of gastric cancer. Hindawi 2021-10-16 /pmc/articles/PMC8541877/ /pubmed/34697541 http://dx.doi.org/10.1155/2021/1173869 Text en Copyright © 2021 Jinchun Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Jinchun Wu, Jie Wang, Lei Min, Xuewen Chen, Zhujing The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2 |
title | The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2 |
title_full | The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2 |
title_fullStr | The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2 |
title_full_unstemmed | The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2 |
title_short | The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2 |
title_sort | linc00152/mir-138 axis facilitates gastric cancer progression by mediating sirt2 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541877/ https://www.ncbi.nlm.nih.gov/pubmed/34697541 http://dx.doi.org/10.1155/2021/1173869 |
work_keys_str_mv | AT wangjinchun thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 AT wujie thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 AT wanglei thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 AT minxuewen thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 AT chenzhujing thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 AT wangjinchun linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 AT wujie linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 AT wanglei linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 AT minxuewen linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 AT chenzhujing linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2 |