Cargando…

The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2

Gastric cancer (GC) is the most common gastrointestinal cancer and the main cause of tumor-related death. Exploring markers for early diagnosis and new therapeutic targets is always on the way. In the last 10 years, long noncoding RNAs (lncRNAs) have been widely proved to be involved in the progress...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jinchun, Wu, Jie, Wang, Lei, Min, Xuewen, Chen, Zhujing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541877/
https://www.ncbi.nlm.nih.gov/pubmed/34697541
http://dx.doi.org/10.1155/2021/1173869
_version_ 1784589336210046976
author Wang, Jinchun
Wu, Jie
Wang, Lei
Min, Xuewen
Chen, Zhujing
author_facet Wang, Jinchun
Wu, Jie
Wang, Lei
Min, Xuewen
Chen, Zhujing
author_sort Wang, Jinchun
collection PubMed
description Gastric cancer (GC) is the most common gastrointestinal cancer and the main cause of tumor-related death. Exploring markers for early diagnosis and new therapeutic targets is always on the way. In the last 10 years, long noncoding RNAs (lncRNAs) have been widely proved to be involved in the progress of many tumors and are regarded as potential targets for tumor therapy. We found that LINC00152, a newly identified lncRNA, was significantly upregulated in GC tissues and affected clinicopathological characteristics in GC patients. Furthermore, we observed that LINC00152 knockdown can significantly reduce cell proliferation and promote apoptosis in human gastric cancer cells. Further bioinformatic analysis indicated that LINC00152 competitively bound with miR-138 and regulated the expression of miR-138. Moreover, SIRT2 was further proved to be a downstream target of miR-138. Overall, this study elucidates the molecular mechanism of LINC00152 underlying the malignant phenotype of GC cells by mediating miR-138/SIRT2 axis, which provides a new understanding of the role and molecular mechanism of lncRNA in GC and also provides a new way for the treatment of gastric cancer.
format Online
Article
Text
id pubmed-8541877
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-85418772021-10-24 The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2 Wang, Jinchun Wu, Jie Wang, Lei Min, Xuewen Chen, Zhujing J Oncol Research Article Gastric cancer (GC) is the most common gastrointestinal cancer and the main cause of tumor-related death. Exploring markers for early diagnosis and new therapeutic targets is always on the way. In the last 10 years, long noncoding RNAs (lncRNAs) have been widely proved to be involved in the progress of many tumors and are regarded as potential targets for tumor therapy. We found that LINC00152, a newly identified lncRNA, was significantly upregulated in GC tissues and affected clinicopathological characteristics in GC patients. Furthermore, we observed that LINC00152 knockdown can significantly reduce cell proliferation and promote apoptosis in human gastric cancer cells. Further bioinformatic analysis indicated that LINC00152 competitively bound with miR-138 and regulated the expression of miR-138. Moreover, SIRT2 was further proved to be a downstream target of miR-138. Overall, this study elucidates the molecular mechanism of LINC00152 underlying the malignant phenotype of GC cells by mediating miR-138/SIRT2 axis, which provides a new understanding of the role and molecular mechanism of lncRNA in GC and also provides a new way for the treatment of gastric cancer. Hindawi 2021-10-16 /pmc/articles/PMC8541877/ /pubmed/34697541 http://dx.doi.org/10.1155/2021/1173869 Text en Copyright © 2021 Jinchun Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Jinchun
Wu, Jie
Wang, Lei
Min, Xuewen
Chen, Zhujing
The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2
title The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2
title_full The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2
title_fullStr The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2
title_full_unstemmed The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2
title_short The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2
title_sort linc00152/mir-138 axis facilitates gastric cancer progression by mediating sirt2
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541877/
https://www.ncbi.nlm.nih.gov/pubmed/34697541
http://dx.doi.org/10.1155/2021/1173869
work_keys_str_mv AT wangjinchun thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2
AT wujie thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2
AT wanglei thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2
AT minxuewen thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2
AT chenzhujing thelinc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2
AT wangjinchun linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2
AT wujie linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2
AT wanglei linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2
AT minxuewen linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2
AT chenzhujing linc00152mir138axisfacilitatesgastriccancerprogressionbymediatingsirt2