Time study on the uptake of four different beta-blockers in garden cress (Lepidium sativum) as a model plant

The aim of this study was to investigate the uptake of four beta-blockers by the model plant Lepidium sativum (garden cress) and their possible metabolization over a time period of 8 days. Therefore, cress was grown hydroponically in tap water for a week until they were matured, following irrigation...

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Autores principales: Mlynek, Franz, Himmelsbach, Markus, Buchberger, Wolfgang, Klampfl, Christian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Recent Developments and Innovative Strategies in Environmental Sciences in Europe
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541974/
https://www.ncbi.nlm.nih.gov/pubmed/33206294
http://dx.doi.org/10.1007/s11356-020-11610-5
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author Mlynek, Franz
Himmelsbach, Markus
Buchberger, Wolfgang
Klampfl, Christian W.
author_facet Mlynek, Franz
Himmelsbach, Markus
Buchberger, Wolfgang
Klampfl, Christian W.
author_sort Mlynek, Franz
collection PubMed
description The aim of this study was to investigate the uptake of four beta-blockers by the model plant Lepidium sativum (garden cress) and their possible metabolization over a time period of 8 days. Therefore, cress was grown hydroponically in tap water for a week until they were matured, following irrigation with drug-containing water over the course of another 8 days. Samples were taken at days 1, 2, 4, and 8 after irrigation started. All four beta-blockers were taken up by the plants and the different octanol-water coefficients (log P) of the drugs have an influence on the uptake speed in the roots of the plants. The log P seems to have no influence on the translocation of the drugs from the root to the shoots. Furthermore, neither phase I nor phase II metabolization occurred inside the plants.
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spelling pubmed-85419742021-10-27 Time study on the uptake of four different beta-blockers in garden cress (Lepidium sativum) as a model plant Mlynek, Franz Himmelsbach, Markus Buchberger, Wolfgang Klampfl, Christian W. Environ Sci Pollut Res Int Recent Developments and Innovative Strategies in Environmental Sciences in Europe The aim of this study was to investigate the uptake of four beta-blockers by the model plant Lepidium sativum (garden cress) and their possible metabolization over a time period of 8 days. Therefore, cress was grown hydroponically in tap water for a week until they were matured, following irrigation with drug-containing water over the course of another 8 days. Samples were taken at days 1, 2, 4, and 8 after irrigation started. All four beta-blockers were taken up by the plants and the different octanol-water coefficients (log P) of the drugs have an influence on the uptake speed in the roots of the plants. The log P seems to have no influence on the translocation of the drugs from the root to the shoots. Furthermore, neither phase I nor phase II metabolization occurred inside the plants. Springer Berlin Heidelberg 2020-11-18 2021 /pmc/articles/PMC8541974/ /pubmed/33206294 http://dx.doi.org/10.1007/s11356-020-11610-5 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Recent Developments and Innovative Strategies in Environmental Sciences in Europe
Mlynek, Franz
Himmelsbach, Markus
Buchberger, Wolfgang
Klampfl, Christian W.
Time study on the uptake of four different beta-blockers in garden cress (Lepidium sativum) as a model plant
title Time study on the uptake of four different beta-blockers in garden cress (Lepidium sativum) as a model plant
title_full Time study on the uptake of four different beta-blockers in garden cress (Lepidium sativum) as a model plant
title_fullStr Time study on the uptake of four different beta-blockers in garden cress (Lepidium sativum) as a model plant
title_full_unstemmed Time study on the uptake of four different beta-blockers in garden cress (Lepidium sativum) as a model plant
title_short Time study on the uptake of four different beta-blockers in garden cress (Lepidium sativum) as a model plant
title_sort time study on the uptake of four different beta-blockers in garden cress (lepidium sativum) as a model plant
topic Recent Developments and Innovative Strategies in Environmental Sciences in Europe
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541974/
https://www.ncbi.nlm.nih.gov/pubmed/33206294
http://dx.doi.org/10.1007/s11356-020-11610-5
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