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The impact of organic extracts of seasonal PM(2.5) on primary human lung epithelial cells and their chemical characterization

Lung epithelial cells serve as the first line of defense against various inhaled pollutant particles. To investigate the adverse health effects of organic components of fine particulate matter (PM(2.5)) collected in Seoul, South Korea, we selected 12 PM(2.5) samples from May 2016 to January 2017 and...

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Autores principales: Park, Jieun, Lee, Kyoung-Hee, Kim, Hyewon, Woo, Jisu, Heo, Jongbae, Lee, Chang-Hoon, Yi, Seung-Muk, Yoo, Chul-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541986/
https://www.ncbi.nlm.nih.gov/pubmed/34148195
http://dx.doi.org/10.1007/s11356-021-14850-1
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author Park, Jieun
Lee, Kyoung-Hee
Kim, Hyewon
Woo, Jisu
Heo, Jongbae
Lee, Chang-Hoon
Yi, Seung-Muk
Yoo, Chul-Gyu
author_facet Park, Jieun
Lee, Kyoung-Hee
Kim, Hyewon
Woo, Jisu
Heo, Jongbae
Lee, Chang-Hoon
Yi, Seung-Muk
Yoo, Chul-Gyu
author_sort Park, Jieun
collection PubMed
description Lung epithelial cells serve as the first line of defense against various inhaled pollutant particles. To investigate the adverse health effects of organic components of fine particulate matter (PM(2.5)) collected in Seoul, South Korea, we selected 12 PM(2.5) samples from May 2016 to January 2017 and evaluated the effects of organic compounds of PM(2.5) on inflammation, cellular aging, and macroautophagy in human lung epithelial cells isolated directly from healthy donors. Organic extracts of PM(2.5) specifically induced neutrophilic chemokine and interleukin-8 expression via extracellular signal-regulated kinase activation. Moreover, PM(2.5) significantly increased the expression of aging markers (p16, p21, and p27) and activated macroautophagy. Average mass concentrations of organic and elemental carbon had no significant correlations with PM(2.5) effects. However, polycyclic aromatic hydrocarbons and n-alkanes were the most relevant components of PM(2.5) that correlated with neutrophilic inflammation. Vegetative detritus and residential bituminous coal combustion sources strongly correlated with neutrophilic inflammation, aging, and macroautophagy activation. These data suggest that the chemical composition of PM(2.5) is important for determining the adverse health effects of PM(2.5). Our study provides encouraging evidence to regulate the harmful components of PM(2.5) in Seoul. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-021-14850-1.
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spelling pubmed-85419862021-10-27 The impact of organic extracts of seasonal PM(2.5) on primary human lung epithelial cells and their chemical characterization Park, Jieun Lee, Kyoung-Hee Kim, Hyewon Woo, Jisu Heo, Jongbae Lee, Chang-Hoon Yi, Seung-Muk Yoo, Chul-Gyu Environ Sci Pollut Res Int Research Article Lung epithelial cells serve as the first line of defense against various inhaled pollutant particles. To investigate the adverse health effects of organic components of fine particulate matter (PM(2.5)) collected in Seoul, South Korea, we selected 12 PM(2.5) samples from May 2016 to January 2017 and evaluated the effects of organic compounds of PM(2.5) on inflammation, cellular aging, and macroautophagy in human lung epithelial cells isolated directly from healthy donors. Organic extracts of PM(2.5) specifically induced neutrophilic chemokine and interleukin-8 expression via extracellular signal-regulated kinase activation. Moreover, PM(2.5) significantly increased the expression of aging markers (p16, p21, and p27) and activated macroautophagy. Average mass concentrations of organic and elemental carbon had no significant correlations with PM(2.5) effects. However, polycyclic aromatic hydrocarbons and n-alkanes were the most relevant components of PM(2.5) that correlated with neutrophilic inflammation. Vegetative detritus and residential bituminous coal combustion sources strongly correlated with neutrophilic inflammation, aging, and macroautophagy activation. These data suggest that the chemical composition of PM(2.5) is important for determining the adverse health effects of PM(2.5). Our study provides encouraging evidence to regulate the harmful components of PM(2.5) in Seoul. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-021-14850-1. Springer Berlin Heidelberg 2021-06-20 2021 /pmc/articles/PMC8541986/ /pubmed/34148195 http://dx.doi.org/10.1007/s11356-021-14850-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Park, Jieun
Lee, Kyoung-Hee
Kim, Hyewon
Woo, Jisu
Heo, Jongbae
Lee, Chang-Hoon
Yi, Seung-Muk
Yoo, Chul-Gyu
The impact of organic extracts of seasonal PM(2.5) on primary human lung epithelial cells and their chemical characterization
title The impact of organic extracts of seasonal PM(2.5) on primary human lung epithelial cells and their chemical characterization
title_full The impact of organic extracts of seasonal PM(2.5) on primary human lung epithelial cells and their chemical characterization
title_fullStr The impact of organic extracts of seasonal PM(2.5) on primary human lung epithelial cells and their chemical characterization
title_full_unstemmed The impact of organic extracts of seasonal PM(2.5) on primary human lung epithelial cells and their chemical characterization
title_short The impact of organic extracts of seasonal PM(2.5) on primary human lung epithelial cells and their chemical characterization
title_sort impact of organic extracts of seasonal pm(2.5) on primary human lung epithelial cells and their chemical characterization
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541986/
https://www.ncbi.nlm.nih.gov/pubmed/34148195
http://dx.doi.org/10.1007/s11356-021-14850-1
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