Evaluation of efficacy and safety of vertebroplasty in the treatment of osteoporotic vertebral compression fracture: A protocol for systematic review and meta-analysis

BACKGROUND: Osteoporosis is a common condition that affects bones. Osteoporotic vertebral compression fracture (OVCF) is a highly prevalent complication related to osteoporosis. Each year, OVCF affects nearly 700,000 individuals. Nowadays, there are many surgical methods to treat OVCF, and each has distinct advantages. Among them, the efficacy and safeness of vertebroplasty are yet to be established. The present article will systematically ascertain the effectiveness and security of using vertebroplasty to treat OVCF. METHODS: All articles related to the research topic published from establishment to July 2021 will be retrieved from the following e-databases Medline, Cochrane library, PubMed database, China National of Knowledge Infrastructure, Web of Science, Embase database, and WanFang database. The collected articles will be related to the use of vertebroplasty to treat OVCF. All included articles will adhere to the standards, and will be screened by 2 independent authors. After extracting the data in the article, Review Manager 5.3 software will be used for data analysis. RESULTS: This study will assess the efficacy and safety of using vertebroplasty to treat OVCF by pooling the results of each study. CONCLUSION: Our findings will present strong evidence to help determine whether vertebroplasty therapy is efficient and safe for OVCF patients.