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Fluoroquinolone antibiotics and adverse events

Fluoroquinolones are broad-spectrum antibiotics with good oral bioavailability. They are used for the treatment of a wide variety of infections, but there are restrictions on prescribing these drugs. Epidemiological studies have reported an increased risk of rare adverse effects. These include tendi...

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Detalles Bibliográficos
Autores principales: Baggio, Diva, Ananda-Rajah, Michelle R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: NPS MedicineWise 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542490/
https://www.ncbi.nlm.nih.gov/pubmed/34728881
http://dx.doi.org/10.18773/austprescr.2021.035
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author Baggio, Diva
Ananda-Rajah, Michelle R
author_facet Baggio, Diva
Ananda-Rajah, Michelle R
author_sort Baggio, Diva
collection PubMed
description Fluoroquinolones are broad-spectrum antibiotics with good oral bioavailability. They are used for the treatment of a wide variety of infections, but there are restrictions on prescribing these drugs. Epidemiological studies have reported an increased risk of rare adverse effects. These include tendinopathy and tendon rupture, peripheral neuropathy and aortic aneurysm. Safe prescribing of fluroquinolones requires recognition of patients with risk factors for toxicity. Prompt drug discontinuation is recommended in the event of an adverse reaction. Practising antimicrobial stewardship by prescribing fluoroquinolones only when alternative drugs are unavailable is also key to limiting adverse events and antibiotic resistance.
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spelling pubmed-85424902021-11-01 Fluoroquinolone antibiotics and adverse events Baggio, Diva Ananda-Rajah, Michelle R Aust Prescr Article Fluoroquinolones are broad-spectrum antibiotics with good oral bioavailability. They are used for the treatment of a wide variety of infections, but there are restrictions on prescribing these drugs. Epidemiological studies have reported an increased risk of rare adverse effects. These include tendinopathy and tendon rupture, peripheral neuropathy and aortic aneurysm. Safe prescribing of fluroquinolones requires recognition of patients with risk factors for toxicity. Prompt drug discontinuation is recommended in the event of an adverse reaction. Practising antimicrobial stewardship by prescribing fluoroquinolones only when alternative drugs are unavailable is also key to limiting adverse events and antibiotic resistance. NPS MedicineWise 2021-10-01 2021-10 /pmc/articles/PMC8542490/ /pubmed/34728881 http://dx.doi.org/10.18773/austprescr.2021.035 Text en (c) NPS MedicineWise https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License.
spellingShingle Article
Baggio, Diva
Ananda-Rajah, Michelle R
Fluoroquinolone antibiotics and adverse events
title Fluoroquinolone antibiotics and adverse events
title_full Fluoroquinolone antibiotics and adverse events
title_fullStr Fluoroquinolone antibiotics and adverse events
title_full_unstemmed Fluoroquinolone antibiotics and adverse events
title_short Fluoroquinolone antibiotics and adverse events
title_sort fluoroquinolone antibiotics and adverse events
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542490/
https://www.ncbi.nlm.nih.gov/pubmed/34728881
http://dx.doi.org/10.18773/austprescr.2021.035
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