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Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Benign Prostatic Hyperplasia

OBJECTIVE: To investigate the immune profiles in benign prostatic hyperplasia, changes in the absolute number of lymphocyte subsets and the proportion of T lymphocyte subsets were detected. METHODS: Absolute value of lymphocyte subsets in peripheral blood (T, B and NK cells) and the proportion of T...

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Autores principales: Li, Ming, Xu, Da-Ming, Lin, Shu-Bin, Yang, Zheng-Liang, Xu, Teng-Yu, Yang, Jin-Huan, Lin, Ze-Xin, Huang, Ze-Kai, Yin, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542518/
https://www.ncbi.nlm.nih.gov/pubmed/34707387
http://dx.doi.org/10.2147/IJGM.S340018
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author Li, Ming
Xu, Da-Ming
Lin, Shu-Bin
Yang, Zheng-Liang
Xu, Teng-Yu
Yang, Jin-Huan
Lin, Ze-Xin
Huang, Ze-Kai
Yin, Jun
author_facet Li, Ming
Xu, Da-Ming
Lin, Shu-Bin
Yang, Zheng-Liang
Xu, Teng-Yu
Yang, Jin-Huan
Lin, Ze-Xin
Huang, Ze-Kai
Yin, Jun
author_sort Li, Ming
collection PubMed
description OBJECTIVE: To investigate the immune profiles in benign prostatic hyperplasia, changes in the absolute number of lymphocyte subsets and the proportion of T lymphocyte subsets were detected. METHODS: Absolute value of lymphocyte subsets in peripheral blood (T, B and NK cells) and the proportion of T lymphocyte (native CD4(+) T cell, memory CD4(+) T cell, CD8(+)CD28(+) T cell, CD8(+)CDDR(+) T cells and CD8(+)CD38(+) T cell) were measured by flow cytometry. RESULTS: The absolute values of CD3(+) T cell (972.55±330.31 vs 1757.99±439.38), CD4(+) T cell (656.43±252.39 vs 899.30±262.10), and CD8(+) T cell (301.97±147.76 vs 728.45±230.34) in patients with benign prostatic hyperplasia were significantly reduced (all P<0.05). There was no significant difference in NK cell (285.58±182.84 vs 528.92±208.17) and B cell (186.66±86.62 vs 334.17±130.46). The proportion of naive CD4(+) T cell (3.75±0.50 vs 8.54±1.61) in T lymphocyte subsets in patients with BPH was significantly reduced (P<0.05). There was no significant difference in memory CD4(+) T cell (87.9±6.37 vs 92.63±5.94), CD8(+)CD28(+) T cell (60.52±13.86 vs 64.32±12.78), CD8(+)CDDR(+) T cell (36.58±12.87 vs 31.92±8.54) and CD8(+)CD38(+) T cell (2.1±1.90 vs 2.55±2.01). CONCLUSION: Immune dysfunction raised the risk of viral infection, inflammatory stimulation, and tumor induction in prostate cells, leading to hyperplasia, and immune non-response was potentially a key factor in the transformation of BPH into prostate cancer.
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spelling pubmed-85425182021-10-26 Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Benign Prostatic Hyperplasia Li, Ming Xu, Da-Ming Lin, Shu-Bin Yang, Zheng-Liang Xu, Teng-Yu Yang, Jin-Huan Lin, Ze-Xin Huang, Ze-Kai Yin, Jun Int J Gen Med Original Research OBJECTIVE: To investigate the immune profiles in benign prostatic hyperplasia, changes in the absolute number of lymphocyte subsets and the proportion of T lymphocyte subsets were detected. METHODS: Absolute value of lymphocyte subsets in peripheral blood (T, B and NK cells) and the proportion of T lymphocyte (native CD4(+) T cell, memory CD4(+) T cell, CD8(+)CD28(+) T cell, CD8(+)CDDR(+) T cells and CD8(+)CD38(+) T cell) were measured by flow cytometry. RESULTS: The absolute values of CD3(+) T cell (972.55±330.31 vs 1757.99±439.38), CD4(+) T cell (656.43±252.39 vs 899.30±262.10), and CD8(+) T cell (301.97±147.76 vs 728.45±230.34) in patients with benign prostatic hyperplasia were significantly reduced (all P<0.05). There was no significant difference in NK cell (285.58±182.84 vs 528.92±208.17) and B cell (186.66±86.62 vs 334.17±130.46). The proportion of naive CD4(+) T cell (3.75±0.50 vs 8.54±1.61) in T lymphocyte subsets in patients with BPH was significantly reduced (P<0.05). There was no significant difference in memory CD4(+) T cell (87.9±6.37 vs 92.63±5.94), CD8(+)CD28(+) T cell (60.52±13.86 vs 64.32±12.78), CD8(+)CDDR(+) T cell (36.58±12.87 vs 31.92±8.54) and CD8(+)CD38(+) T cell (2.1±1.90 vs 2.55±2.01). CONCLUSION: Immune dysfunction raised the risk of viral infection, inflammatory stimulation, and tumor induction in prostate cells, leading to hyperplasia, and immune non-response was potentially a key factor in the transformation of BPH into prostate cancer. Dove 2021-10-20 /pmc/articles/PMC8542518/ /pubmed/34707387 http://dx.doi.org/10.2147/IJGM.S340018 Text en © 2021 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Li, Ming
Xu, Da-Ming
Lin, Shu-Bin
Yang, Zheng-Liang
Xu, Teng-Yu
Yang, Jin-Huan
Lin, Ze-Xin
Huang, Ze-Kai
Yin, Jun
Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Benign Prostatic Hyperplasia
title Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Benign Prostatic Hyperplasia
title_full Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Benign Prostatic Hyperplasia
title_fullStr Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Benign Prostatic Hyperplasia
title_full_unstemmed Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Benign Prostatic Hyperplasia
title_short Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Benign Prostatic Hyperplasia
title_sort investigation of lymphocyte subsets in peripheral blood of patients with benign prostatic hyperplasia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542518/
https://www.ncbi.nlm.nih.gov/pubmed/34707387
http://dx.doi.org/10.2147/IJGM.S340018
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