Cargando…
Adverse Effects of Higher Preoperative Pain at Rest, a Central Sensitization-Related Symptom, on Outcomes After Total Hip Arthroplasty in Patients with Osteoarthritis
BACKGROUND: In patients with hip osteoarthritis (OA), pain at rest, unlike pain on activity, is due to pain mechanisms that cannot be explained by nociceptive pain. However, it remains unclear whether central sensitization (CS) is one of the causes of exacerbated pain at rest in patients with hip OA...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542571/ https://www.ncbi.nlm.nih.gov/pubmed/34707402 http://dx.doi.org/10.2147/JPR.S322314 |
_version_ | 1784589458545311744 |
---|---|
author | Ohashi, Yoshihisa Fukushima, Kensuke Uchida, Kentaro Koyama, Tomohisa Tsuchiya, Maho Saito, Hiroki Uchiyama, Katsufumi Takahira, Naonobu Inoue, Gen Takaso, Masashi |
author_facet | Ohashi, Yoshihisa Fukushima, Kensuke Uchida, Kentaro Koyama, Tomohisa Tsuchiya, Maho Saito, Hiroki Uchiyama, Katsufumi Takahira, Naonobu Inoue, Gen Takaso, Masashi |
author_sort | Ohashi, Yoshihisa |
collection | PubMed |
description | BACKGROUND: In patients with hip osteoarthritis (OA), pain at rest, unlike pain on activity, is due to pain mechanisms that cannot be explained by nociceptive pain. However, it remains unclear whether central sensitization (CS) is one of the causes of exacerbated pain at rest in patients with hip OA. Therefore, we investigated the differences in causative factors and postoperative course of total hip arthroplasty (THA) between preoperative pain at rest and on activity in patients with hip OA. METHODS: In total, 120 patients (125 hips, 22 men and 98 women, aged 64.5±1.0 years) with hip OA were included. Preoperative pain at rest and on activity and CS were assessed using the visual analog scale (VAS) and CS Inventory (CSI), respectively. Postoperative assessments were evaluated using the Japanese Orthopedic Association Hip Disease Evaluation Questionnaire (JHEQ); pain, satisfaction, function, and mental scores were evaluated 6 and 12 months after THA. RESULTS: Multivariate regression analysis indicated the CSI score as affecting VAS for pain at rest (β=0.067, P=0.002) but not VAS for pain on activity (β=0.036, P=0.073). VAS for pain at rest had a weak negative correlation with satisfaction and pain scores at both 6 and 12 months after THA (satisfaction, r=−0.309, −0.278; pain, r=−0.202, −0.22). VAS for pain on activity was not correlated with JHEQ. The CSI score had a weak or moderate negative correlation with three scores other than the function score at both 6 and 12 months after THA (satisfaction, r=−0.266, −0.213; pain, r=−0.332, −0.203, mental, r=−0.427, −0.370). The function score was weakly correlated with the CSI score only 6 months after THA (function, r=−0.231, −0.190). CONCLUSION: A higher level of preoperative pain at rest, a CS-related symptom, may affect postoperative pain persistence and dissatisfaction in patients with hip OA. |
format | Online Article Text |
id | pubmed-8542571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-85425712021-10-26 Adverse Effects of Higher Preoperative Pain at Rest, a Central Sensitization-Related Symptom, on Outcomes After Total Hip Arthroplasty in Patients with Osteoarthritis Ohashi, Yoshihisa Fukushima, Kensuke Uchida, Kentaro Koyama, Tomohisa Tsuchiya, Maho Saito, Hiroki Uchiyama, Katsufumi Takahira, Naonobu Inoue, Gen Takaso, Masashi J Pain Res Original Research BACKGROUND: In patients with hip osteoarthritis (OA), pain at rest, unlike pain on activity, is due to pain mechanisms that cannot be explained by nociceptive pain. However, it remains unclear whether central sensitization (CS) is one of the causes of exacerbated pain at rest in patients with hip OA. Therefore, we investigated the differences in causative factors and postoperative course of total hip arthroplasty (THA) between preoperative pain at rest and on activity in patients with hip OA. METHODS: In total, 120 patients (125 hips, 22 men and 98 women, aged 64.5±1.0 years) with hip OA were included. Preoperative pain at rest and on activity and CS were assessed using the visual analog scale (VAS) and CS Inventory (CSI), respectively. Postoperative assessments were evaluated using the Japanese Orthopedic Association Hip Disease Evaluation Questionnaire (JHEQ); pain, satisfaction, function, and mental scores were evaluated 6 and 12 months after THA. RESULTS: Multivariate regression analysis indicated the CSI score as affecting VAS for pain at rest (β=0.067, P=0.002) but not VAS for pain on activity (β=0.036, P=0.073). VAS for pain at rest had a weak negative correlation with satisfaction and pain scores at both 6 and 12 months after THA (satisfaction, r=−0.309, −0.278; pain, r=−0.202, −0.22). VAS for pain on activity was not correlated with JHEQ. The CSI score had a weak or moderate negative correlation with three scores other than the function score at both 6 and 12 months after THA (satisfaction, r=−0.266, −0.213; pain, r=−0.332, −0.203, mental, r=−0.427, −0.370). The function score was weakly correlated with the CSI score only 6 months after THA (function, r=−0.231, −0.190). CONCLUSION: A higher level of preoperative pain at rest, a CS-related symptom, may affect postoperative pain persistence and dissatisfaction in patients with hip OA. Dove 2021-10-20 /pmc/articles/PMC8542571/ /pubmed/34707402 http://dx.doi.org/10.2147/JPR.S322314 Text en © 2021 Ohashi et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Ohashi, Yoshihisa Fukushima, Kensuke Uchida, Kentaro Koyama, Tomohisa Tsuchiya, Maho Saito, Hiroki Uchiyama, Katsufumi Takahira, Naonobu Inoue, Gen Takaso, Masashi Adverse Effects of Higher Preoperative Pain at Rest, a Central Sensitization-Related Symptom, on Outcomes After Total Hip Arthroplasty in Patients with Osteoarthritis |
title | Adverse Effects of Higher Preoperative Pain at Rest, a Central Sensitization-Related Symptom, on Outcomes After Total Hip Arthroplasty in Patients with Osteoarthritis |
title_full | Adverse Effects of Higher Preoperative Pain at Rest, a Central Sensitization-Related Symptom, on Outcomes After Total Hip Arthroplasty in Patients with Osteoarthritis |
title_fullStr | Adverse Effects of Higher Preoperative Pain at Rest, a Central Sensitization-Related Symptom, on Outcomes After Total Hip Arthroplasty in Patients with Osteoarthritis |
title_full_unstemmed | Adverse Effects of Higher Preoperative Pain at Rest, a Central Sensitization-Related Symptom, on Outcomes After Total Hip Arthroplasty in Patients with Osteoarthritis |
title_short | Adverse Effects of Higher Preoperative Pain at Rest, a Central Sensitization-Related Symptom, on Outcomes After Total Hip Arthroplasty in Patients with Osteoarthritis |
title_sort | adverse effects of higher preoperative pain at rest, a central sensitization-related symptom, on outcomes after total hip arthroplasty in patients with osteoarthritis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542571/ https://www.ncbi.nlm.nih.gov/pubmed/34707402 http://dx.doi.org/10.2147/JPR.S322314 |
work_keys_str_mv | AT ohashiyoshihisa adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis AT fukushimakensuke adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis AT uchidakentaro adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis AT koyamatomohisa adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis AT tsuchiyamaho adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis AT saitohiroki adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis AT uchiyamakatsufumi adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis AT takahiranaonobu adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis AT inouegen adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis AT takasomasashi adverseeffectsofhigherpreoperativepainatrestacentralsensitizationrelatedsymptomonoutcomesaftertotalhiparthroplastyinpatientswithosteoarthritis |