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Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth

Many storage mediums are available for the storage of avulsed teeth to preserve the viability of periodontal ligament (PDL) cells before replantation; however, it is unclear which medium is the optimal option. We performed this network meta-analysis to answer this question. A comprehensive search wa...

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Autores principales: Zhang, Na, Cheng, Yuzhao, Li, Fenglan, Kang, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542672/
https://www.ncbi.nlm.nih.gov/pubmed/34708058
http://dx.doi.org/10.3389/fmed.2021.749278
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author Zhang, Na
Cheng, Yuzhao
Li, Fenglan
Kang, Qian
author_facet Zhang, Na
Cheng, Yuzhao
Li, Fenglan
Kang, Qian
author_sort Zhang, Na
collection PubMed
description Many storage mediums are available for the storage of avulsed teeth to preserve the viability of periodontal ligament (PDL) cells before replantation; however, it is unclear which medium is the optimal option. We performed this network meta-analysis to answer this question. A comprehensive search was conducted in PubMed, EMBASE, and the Cochrane library to capture eligible studies investigating the comparative efficacy of Hank's balanced salt solution (HBSS), aloe vera gel (AVG), oral rehydration solution (ORS), coconut water, egg white, green tea, propolis, saline, milk, and water. Statistical analysis was conducted using Review Manager v5.3 and ADDIS v1.16.8. In total, 20 RCTs involving 31 reports were included finally. Direct meta-analysis suggested that HBSS was superior to ORS, milk, saline, and water, ORS was superior to milk but inferior to coconut water and propolis, egg white was superior to milk but inferior to AVG and propolis, propolis was superior to AVG, milk, and saline, and coconut water and water was inferior to saline and milk, respectively. Network meta-analysis suggested that AVG was inferior to the other nine mediums, and propolis was superior to HBSS (SMD, −5260.24; 95% CrI, −10447.39 to −70.37) and milk (SMD, −5461.11; 95% CrI, −10574.99 to −328.51). Moreover, ranking probabilities indicated the highest probability for propolis, followed by saline, ORS, HBSS, milk, egg white, water, green tea, and AVG successively. Propolis may be the optimal media for storing avulsed teeth before replantation. However, given the availability of propolis and HBSS and the hypotonic properties of saline, ORS or milk should also be preferentially selected.
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spelling pubmed-85426722021-10-26 Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth Zhang, Na Cheng, Yuzhao Li, Fenglan Kang, Qian Front Med (Lausanne) Medicine Many storage mediums are available for the storage of avulsed teeth to preserve the viability of periodontal ligament (PDL) cells before replantation; however, it is unclear which medium is the optimal option. We performed this network meta-analysis to answer this question. A comprehensive search was conducted in PubMed, EMBASE, and the Cochrane library to capture eligible studies investigating the comparative efficacy of Hank's balanced salt solution (HBSS), aloe vera gel (AVG), oral rehydration solution (ORS), coconut water, egg white, green tea, propolis, saline, milk, and water. Statistical analysis was conducted using Review Manager v5.3 and ADDIS v1.16.8. In total, 20 RCTs involving 31 reports were included finally. Direct meta-analysis suggested that HBSS was superior to ORS, milk, saline, and water, ORS was superior to milk but inferior to coconut water and propolis, egg white was superior to milk but inferior to AVG and propolis, propolis was superior to AVG, milk, and saline, and coconut water and water was inferior to saline and milk, respectively. Network meta-analysis suggested that AVG was inferior to the other nine mediums, and propolis was superior to HBSS (SMD, −5260.24; 95% CrI, −10447.39 to −70.37) and milk (SMD, −5461.11; 95% CrI, −10574.99 to −328.51). Moreover, ranking probabilities indicated the highest probability for propolis, followed by saline, ORS, HBSS, milk, egg white, water, green tea, and AVG successively. Propolis may be the optimal media for storing avulsed teeth before replantation. However, given the availability of propolis and HBSS and the hypotonic properties of saline, ORS or milk should also be preferentially selected. Frontiers Media S.A. 2021-10-11 /pmc/articles/PMC8542672/ /pubmed/34708058 http://dx.doi.org/10.3389/fmed.2021.749278 Text en Copyright © 2021 Zhang, Cheng, Li and Kang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhang, Na
Cheng, Yuzhao
Li, Fenglan
Kang, Qian
Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth
title Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth
title_full Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth
title_fullStr Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth
title_full_unstemmed Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth
title_short Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth
title_sort network meta-analysis of 10 storage mediums for preserving avulsed teeth
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542672/
https://www.ncbi.nlm.nih.gov/pubmed/34708058
http://dx.doi.org/10.3389/fmed.2021.749278
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