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The Biomechanical Response of the Cornea in Orthokeratology

Orthokeratology has been widely used to control myopia, but the mechanism is still unknown. To further investigate the underlying mechanism of corneal reshaping using orthokeratology lenses via the finite element method, numerical models with different corneal curvatures, corneal thicknesses, and my...

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Autores principales: Wu, Jinfang, Fang, Wenxuan, Xu, Huiwen, Liu, Xiaode, Zhao, Dongliang, Rong, Qiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542762/
https://www.ncbi.nlm.nih.gov/pubmed/34708026
http://dx.doi.org/10.3389/fbioe.2021.743745
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author Wu, Jinfang
Fang, Wenxuan
Xu, Huiwen
Liu, Xiaode
Zhao, Dongliang
Rong, Qiguo
author_facet Wu, Jinfang
Fang, Wenxuan
Xu, Huiwen
Liu, Xiaode
Zhao, Dongliang
Rong, Qiguo
author_sort Wu, Jinfang
collection PubMed
description Orthokeratology has been widely used to control myopia, but the mechanism is still unknown. To further investigate the underlying mechanism of corneal reshaping using orthokeratology lenses via the finite element method, numerical models with different corneal curvatures, corneal thicknesses, and myopia reduction degrees had been developed and validated to simulate the corneal response and quantify the changes in maximum stress in the central and peripheral corneal areas during orthokeratology. The influence of the factors on corneal response had been analyzed by using median quantile regression. A partial eta squared value in analysis of variance models was established to compare the effect size of these factors. The results showed central and peripheral corneal stress responses changed significantly with increased myopia reduction, corneal curvature, and corneal thickness. The target myopia reduction had the greatest effect on the central corneal stress value (partial eta square = 0.9382), followed by corneal curvature (partial eta square = 0.5650) and corneal thickness (partial eta square = 0.1975). The corneal curvature had the greatest effect on the peripheral corneal stress value (partial eta square = 0.5220), followed by myopia reduction (partial eta square = 0.2375) and corneal thickness (partial eta square = 0.1972). In summary, the biomechanical response of the cornea varies significantly with the change in corneal conditions and lens designs. Therefore, the orthokeratology lens design and the lens fitting process should be taken into consideration in clinical practice, especially for patients with high myopia and steep corneas.
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spelling pubmed-85427622021-10-26 The Biomechanical Response of the Cornea in Orthokeratology Wu, Jinfang Fang, Wenxuan Xu, Huiwen Liu, Xiaode Zhao, Dongliang Rong, Qiguo Front Bioeng Biotechnol Bioengineering and Biotechnology Orthokeratology has been widely used to control myopia, but the mechanism is still unknown. To further investigate the underlying mechanism of corneal reshaping using orthokeratology lenses via the finite element method, numerical models with different corneal curvatures, corneal thicknesses, and myopia reduction degrees had been developed and validated to simulate the corneal response and quantify the changes in maximum stress in the central and peripheral corneal areas during orthokeratology. The influence of the factors on corneal response had been analyzed by using median quantile regression. A partial eta squared value in analysis of variance models was established to compare the effect size of these factors. The results showed central and peripheral corneal stress responses changed significantly with increased myopia reduction, corneal curvature, and corneal thickness. The target myopia reduction had the greatest effect on the central corneal stress value (partial eta square = 0.9382), followed by corneal curvature (partial eta square = 0.5650) and corneal thickness (partial eta square = 0.1975). The corneal curvature had the greatest effect on the peripheral corneal stress value (partial eta square = 0.5220), followed by myopia reduction (partial eta square = 0.2375) and corneal thickness (partial eta square = 0.1972). In summary, the biomechanical response of the cornea varies significantly with the change in corneal conditions and lens designs. Therefore, the orthokeratology lens design and the lens fitting process should be taken into consideration in clinical practice, especially for patients with high myopia and steep corneas. Frontiers Media S.A. 2021-10-11 /pmc/articles/PMC8542762/ /pubmed/34708026 http://dx.doi.org/10.3389/fbioe.2021.743745 Text en Copyright © 2021 Wu, Fang, Xu, Liu, Zhao and Rong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wu, Jinfang
Fang, Wenxuan
Xu, Huiwen
Liu, Xiaode
Zhao, Dongliang
Rong, Qiguo
The Biomechanical Response of the Cornea in Orthokeratology
title The Biomechanical Response of the Cornea in Orthokeratology
title_full The Biomechanical Response of the Cornea in Orthokeratology
title_fullStr The Biomechanical Response of the Cornea in Orthokeratology
title_full_unstemmed The Biomechanical Response of the Cornea in Orthokeratology
title_short The Biomechanical Response of the Cornea in Orthokeratology
title_sort biomechanical response of the cornea in orthokeratology
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542762/
https://www.ncbi.nlm.nih.gov/pubmed/34708026
http://dx.doi.org/10.3389/fbioe.2021.743745
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