Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?

Emerging concerns following the severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) pandemic are the long-term effects of coronavirus disease (COVID)-19. Dysgeusia in COVID-19 is supported by the abundant expression of the entry receptor, angiotensin-converting enzyme-2 (ACE2), in the oral m...

Descripción completa

Detalles Bibliográficos
Autores principales: Ermel, Aaron, Thyvalikakath, Thankam Paul, Foroud, Tatiana, Khan, Babar, Srinivasan, Mythily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542928/
https://www.ncbi.nlm.nih.gov/pubmed/34707585
http://dx.doi.org/10.3389/fmicb.2021.727430
_version_ 1784589532602040320
author Ermel, Aaron
Thyvalikakath, Thankam Paul
Foroud, Tatiana
Khan, Babar
Srinivasan, Mythily
author_facet Ermel, Aaron
Thyvalikakath, Thankam Paul
Foroud, Tatiana
Khan, Babar
Srinivasan, Mythily
author_sort Ermel, Aaron
collection PubMed
description Emerging concerns following the severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) pandemic are the long-term effects of coronavirus disease (COVID)-19. Dysgeusia in COVID-19 is supported by the abundant expression of the entry receptor, angiotensin-converting enzyme-2 (ACE2), in the oral mucosa. The invading virus perturbs the commensal biofilm and regulates the host responses that permit or suppress viral infection. We correlated the microbial recognition receptors and soluble ACE2 (sACE2) with the SARS-CoV2 measures in the saliva of COVID-19 patients. Data indicate that the toll-like receptor-4, peptidoglycan recognition protein, and sACE2 are elevated in COVID-19 saliva and correlate moderately with the viral load.
format Online
Article
Text
id pubmed-8542928
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85429282021-10-26 Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19? Ermel, Aaron Thyvalikakath, Thankam Paul Foroud, Tatiana Khan, Babar Srinivasan, Mythily Front Microbiol Microbiology Emerging concerns following the severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) pandemic are the long-term effects of coronavirus disease (COVID)-19. Dysgeusia in COVID-19 is supported by the abundant expression of the entry receptor, angiotensin-converting enzyme-2 (ACE2), in the oral mucosa. The invading virus perturbs the commensal biofilm and regulates the host responses that permit or suppress viral infection. We correlated the microbial recognition receptors and soluble ACE2 (sACE2) with the SARS-CoV2 measures in the saliva of COVID-19 patients. Data indicate that the toll-like receptor-4, peptidoglycan recognition protein, and sACE2 are elevated in COVID-19 saliva and correlate moderately with the viral load. Frontiers Media S.A. 2021-10-11 /pmc/articles/PMC8542928/ /pubmed/34707585 http://dx.doi.org/10.3389/fmicb.2021.727430 Text en Copyright © 2021 Ermel, Thyvalikakath, Foroud, Khan and Srinivasan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ermel, Aaron
Thyvalikakath, Thankam Paul
Foroud, Tatiana
Khan, Babar
Srinivasan, Mythily
Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?
title Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?
title_full Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?
title_fullStr Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?
title_full_unstemmed Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?
title_short Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?
title_sort can salivary innate immune molecules provide clue on taste dysfunction in covid-19?
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542928/
https://www.ncbi.nlm.nih.gov/pubmed/34707585
http://dx.doi.org/10.3389/fmicb.2021.727430
work_keys_str_mv AT ermelaaron cansalivaryinnateimmunemoleculesprovideclueontastedysfunctionincovid19
AT thyvalikakaththankampaul cansalivaryinnateimmunemoleculesprovideclueontastedysfunctionincovid19
AT foroudtatiana cansalivaryinnateimmunemoleculesprovideclueontastedysfunctionincovid19
AT khanbabar cansalivaryinnateimmunemoleculesprovideclueontastedysfunctionincovid19
AT srinivasanmythily cansalivaryinnateimmunemoleculesprovideclueontastedysfunctionincovid19

Ejemplares similares