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Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China

Although the pathologic investigation of liver injury was observed in a couple of cases in China, the detailed description of liver histopathologic and ultrastructural changes in a relatively larger series of liver tissues from COVID-19 patients is lacking. Samples from the liver were obtained from...

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Autores principales: Chu, Huikuan, Peng, Li, Hu, Lilin, Zhu, Yixin, Zhao, Jinfang, Su, Hua, Yao, Lin, Zhu, Qingjing, Nie, Xiu, Yang, Ling, Hou, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543004/
https://www.ncbi.nlm.nih.gov/pubmed/34708059
http://dx.doi.org/10.3389/fmed.2021.749318
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author Chu, Huikuan
Peng, Li
Hu, Lilin
Zhu, Yixin
Zhao, Jinfang
Su, Hua
Yao, Lin
Zhu, Qingjing
Nie, Xiu
Yang, Ling
Hou, Xiaohua
author_facet Chu, Huikuan
Peng, Li
Hu, Lilin
Zhu, Yixin
Zhao, Jinfang
Su, Hua
Yao, Lin
Zhu, Qingjing
Nie, Xiu
Yang, Ling
Hou, Xiaohua
author_sort Chu, Huikuan
collection PubMed
description Although the pathologic investigation of liver injury was observed in a couple of cases in China, the detailed description of liver histopathologic and ultrastructural changes in a relatively larger series of liver tissues from COVID-19 patients is lacking. Samples from the liver were obtained from 24 COVID-19 cases from February 1 to April 1, 2020. Light microscopy showed that all liver sections had different degrees of liver injury manifested as swelling of the hepatocytes, hepatocellular necrosis, steatosis, lobular inflammation, portal inflammation, dilatation of sinusoids, and so on. SARS-CoV-2 induced liver injury might be independent of pre-existing Schistosoma infection or obstructive cholestasis. Patients combined with respiratory failure had more severe hepatocellular necrosis and male patients were more susceptible to liver injury. Although coronavirus particles or viral inclusions were not detected in the liver tissues for all cases, vacuolar degenerations in hepatocytes, edematous of mitochondria with the disruption of cristae, and expansions of the endoplasmic reticulum were observed. In conclusion, pathologic changes of liver tissues provide us a further understanding of liver injury in COVID-19 patients. Changes in the liver seem to be related to the underlying diseases/conditions.
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spelling pubmed-85430042021-10-26 Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China Chu, Huikuan Peng, Li Hu, Lilin Zhu, Yixin Zhao, Jinfang Su, Hua Yao, Lin Zhu, Qingjing Nie, Xiu Yang, Ling Hou, Xiaohua Front Med (Lausanne) Medicine Although the pathologic investigation of liver injury was observed in a couple of cases in China, the detailed description of liver histopathologic and ultrastructural changes in a relatively larger series of liver tissues from COVID-19 patients is lacking. Samples from the liver were obtained from 24 COVID-19 cases from February 1 to April 1, 2020. Light microscopy showed that all liver sections had different degrees of liver injury manifested as swelling of the hepatocytes, hepatocellular necrosis, steatosis, lobular inflammation, portal inflammation, dilatation of sinusoids, and so on. SARS-CoV-2 induced liver injury might be independent of pre-existing Schistosoma infection or obstructive cholestasis. Patients combined with respiratory failure had more severe hepatocellular necrosis and male patients were more susceptible to liver injury. Although coronavirus particles or viral inclusions were not detected in the liver tissues for all cases, vacuolar degenerations in hepatocytes, edematous of mitochondria with the disruption of cristae, and expansions of the endoplasmic reticulum were observed. In conclusion, pathologic changes of liver tissues provide us a further understanding of liver injury in COVID-19 patients. Changes in the liver seem to be related to the underlying diseases/conditions. Frontiers Media S.A. 2021-10-11 /pmc/articles/PMC8543004/ /pubmed/34708059 http://dx.doi.org/10.3389/fmed.2021.749318 Text en Copyright © 2021 Chu, Peng, Hu, Zhu, Zhao, Su, Yao, Zhu, Nie, Yang and Hou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Chu, Huikuan
Peng, Li
Hu, Lilin
Zhu, Yixin
Zhao, Jinfang
Su, Hua
Yao, Lin
Zhu, Qingjing
Nie, Xiu
Yang, Ling
Hou, Xiaohua
Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China
title Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China
title_full Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China
title_fullStr Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China
title_full_unstemmed Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China
title_short Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China
title_sort liver histopathological analysis of 24 postmortem findings of patients with covid-19 in china
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543004/
https://www.ncbi.nlm.nih.gov/pubmed/34708059
http://dx.doi.org/10.3389/fmed.2021.749318
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