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Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders

Memory and cognitive impairment as sequelae of neurodegeneration in Alzheimer’s disease and age-related dementia are major health issues with increasing social and economic burden. Deep brain stimulation (DBS) has emerged as a potential treatment to slow or halt progression of the disease state. The...

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Autores principales: Subramaniam, Saravanan, Blake, David T., Constantinidis, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543284/
https://www.ncbi.nlm.nih.gov/pubmed/34334401
http://dx.doi.org/10.3233/JAD-210425
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author Subramaniam, Saravanan
Blake, David T.
Constantinidis, Christos
author_facet Subramaniam, Saravanan
Blake, David T.
Constantinidis, Christos
author_sort Subramaniam, Saravanan
collection PubMed
description Memory and cognitive impairment as sequelae of neurodegeneration in Alzheimer’s disease and age-related dementia are major health issues with increasing social and economic burden. Deep brain stimulation (DBS) has emerged as a potential treatment to slow or halt progression of the disease state. The selection of stimulation target is critical, and structures that have been targeted for memory and cognitive enhancement include the Papez circuit, structures projecting to the frontal lobe such as the ventral internal capsule, and the cholinergic forebrain. Recent human clinical and animal model results imply that DBS of the nucleus basalis of Meynert can induce a therapeutic modulation of neuronal activity. Benefits include enhanced activity across the cortical mantle, and potential for amelioration of neuropathological mechanisms associated with Alzheimer’s disease. The choice of stimulation parameters is also critical. High-frequency, continuous stimulation is used for movement disorders as a way of inhibiting their output; however, no overexcitation has been hypothesized in Alzheimer’s disease and lower stimulation frequency or intermittent patterns of stimulation (periods of stimulation interleaved with periods of no stimulation) are likely to be more effective for stimulation of the cholinergic forebrain. Efficacy and long-term tolerance in human patients remain open questions, though the cumulative experience gained by DBS for movement disorders provides assurance for the safety of the procedure.
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spelling pubmed-85432842021-11-10 Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders Subramaniam, Saravanan Blake, David T. Constantinidis, Christos J Alzheimers Dis Review Memory and cognitive impairment as sequelae of neurodegeneration in Alzheimer’s disease and age-related dementia are major health issues with increasing social and economic burden. Deep brain stimulation (DBS) has emerged as a potential treatment to slow or halt progression of the disease state. The selection of stimulation target is critical, and structures that have been targeted for memory and cognitive enhancement include the Papez circuit, structures projecting to the frontal lobe such as the ventral internal capsule, and the cholinergic forebrain. Recent human clinical and animal model results imply that DBS of the nucleus basalis of Meynert can induce a therapeutic modulation of neuronal activity. Benefits include enhanced activity across the cortical mantle, and potential for amelioration of neuropathological mechanisms associated with Alzheimer’s disease. The choice of stimulation parameters is also critical. High-frequency, continuous stimulation is used for movement disorders as a way of inhibiting their output; however, no overexcitation has been hypothesized in Alzheimer’s disease and lower stimulation frequency or intermittent patterns of stimulation (periods of stimulation interleaved with periods of no stimulation) are likely to be more effective for stimulation of the cholinergic forebrain. Efficacy and long-term tolerance in human patients remain open questions, though the cumulative experience gained by DBS for movement disorders provides assurance for the safety of the procedure. IOS Press 2021-09-14 /pmc/articles/PMC8543284/ /pubmed/34334401 http://dx.doi.org/10.3233/JAD-210425 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Subramaniam, Saravanan
Blake, David T.
Constantinidis, Christos
Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders
title Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders
title_full Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders
title_fullStr Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders
title_full_unstemmed Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders
title_short Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders
title_sort cholinergic deep brain stimulation for memory and cognitive disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543284/
https://www.ncbi.nlm.nih.gov/pubmed/34334401
http://dx.doi.org/10.3233/JAD-210425
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