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Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1(+) Macrophage Infiltration

PURPOSE: No lymphatic vessels have been identified in the retina. This study investigated whether pathological VEGF-A–overexpressing diabetic retina causes lymphangiogenesis. METHODS: Three genetic mouse models of diabetic retinopathy (DR) (Akita [Ins2(+/−)], Kimba [vegfa(+/+)], and Akimba [Akita ×...

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Detalles Bibliográficos
Autores principales:	Wada, Iori, Nakao, Shintaro, Yamaguchi, Muneo, Kaizu, Yoshihiro, Arima, Mitsuru, Sawa, Shinichiro, Sonoda, Koh-Hei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2021
Materias:	Retina
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543389/ https://www.ncbi.nlm.nih.gov/pubmed/34673901 http://dx.doi.org/10.1167/iovs.62.13.17

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